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[DOC File]MELATONIN
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Sleep efficiency improved and time awake after onset of sleep decreased. All had low 6-SMT excretion prior to study. One study demonstrated that elderly insomniacs have lower peak melatonin levels than noninsomniacs 20. Short-acting 2 mg eliminated in 35-50 minutes. Sustained-release continued to circulate 5-7 hours.
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[DOCX File]Australian public assessment report for Melatonin
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The ACM agreed that the evidence for a greater benefit from 10 mg melatonin is modest. However, it appears to be of benefit in a small subgroup of patients. The ACM had some concerns regarding the uncertainty of the safety of the 10 mg dose. The ACM advised that the 10 mg dose should be included in the dosage for Slenyto.
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[DOCX File]Attachment: Product Information for Melatonin
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The recommended starting daily dose is 2 mg of SLENYTO. If an inadequate response has been observed, the daily dose should be increased to 5 mg, with a maximal dose of 10 mg. In the clinical study, the treatment with 10 mg of melatonin was required only for a small group of children.
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[DOCX File]Patient Handouts - Redemption Psychiatry
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For benzodiazepine withdrawal in elderly people with insomnia: 2 mg of controlled-release melatonin taken at bedtime for 6 weeks (the benzodiazepine dosage is reduced 50% during the second week, 75% during weeks 3 and 4, and stopped during weeks 5 and 6) and continued up to 6 months.
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10 mg melatonin dosage sleep