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Neurohormonal regulation and myocyte stretch
TOPCAT was a phase 3 randomized, multicenter, international, double-blinded, placebo-controlled trial designed to evaluate the safety and efficacy of spironolactone in individuals older than age 50 years with symptomatic HFpEF, with a left ventricular (LV) ejection fraction ≥45%.
ejection fraction 30 prognosis

[DOC File]FRACP- Cardiology answers
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The left ventricular ejection fraction is also a powerful, independent predictor of prognosis. Whereas the severity of left ventricular dysfunction can be correlated with outcome, (13,14,30,31,34,35,36,37,38,39) the relation between the ejection fraction and survival is weaker in more homogeneous populations, particularly when the ejection ...
heart 35% ejection fraction

[DOC File]Pharmacy Benefits Management Services Home
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After a median follow-up of 38.1 months, the median PFS was 21.8 months for MPT and 14.5 months for MP (P = .004). The median OS was 45.0 months for MPT and 47.6 months for MP (P = .79). The authors pointed out the crossover of MP patients to thalidomide or bortezomib-based salvage regimens as a possible explanation for the lack of survival ...
ejection fraction 25% longevity

For Investors | BridgeBio Pharma
For example, recent literature has suggested that between 12% to 19% of patients diagnosed with heart failure with preserved ejection fraction may, in fact, have undiagnosed ATTR-CM. This single segment represents approximately half of the 6.0 million to 7.0 million estimated people with heart failure in the United States alone.
ejection fraction chf

[DOCX File]Supplemental Methods -cdn.com
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Decompensated hypotension, heart failure, shock, refractory ventricular arrhythmias, acute conduction system disease, implanted defibrillator, or left ventricular ejection fraction ≤ 30%. Known severe allergy, hypersensitivity or contraindication to aspirin, heparin, thienopyridines or contrast which cannot be adequately pre-medicated.
prognosis of 20% heart function

[DOCX File]Imperial College London
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Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for up to half of all HF in the developed world1. The reported population prevalence ranges from 1 to 3%, and is predicted to rise with lengthening life expectancy, greater diagnostic awareness, and increasing rates of obesity, diabetes, hypertension, and atrial fibrillation (AF)1.
ef 40 life expectancy

[DOC File]Hindawi Publishing Corporation
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Noncardiac coexisting condition resulting in life expectancy of less than 1 year or that might result in noncompliance with the study protocol ... NA Park 2010 (REAL-LATE and ZEST-LATE) 62 70% 31% 4% Ejection fraction: 59% 59 26% 4% NA 38%. 62%. 11% Valgimigli 2012 (PRODIGY) 68. 77%. 24%. 27% Ejection fraction: 53%. 53 24%. 4% (cerebrovascular ...
30% ejection fraction life expectancy

38 ejection fraction life expectancy