Acute subacute subchronic chronic definition
[DOC File]Characterizing Inter-species Uncertainty Using Data from
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The appropriateness of using doses and end-points from sub-acute, sub-chronic and chronic studies to establish acute relevant NOAELs needs to be carefully considered. Particular weight should be given to observations and investigations at the beginning of repeated-dose studies.
1 LEGAL FRAMEWORK FOR THE CLASSIFICATION, …
The NEDI for pyroxasulfone is equivalent to 5.2% of the ADI. DIAMOND Modelling of chronic dietary exposure is also performed on new chemicals. The DIAMOND model estimated the chronic dietary exposure of pyroxasulfone as 4.5% of the ADI for the general population. The acute dietary intake risk for pyroxasulfone has been assessed.
What is Acute, Subacute and Chronic? | Healthhype.com
Definition of terms in Chapter 2, Part 2 of the IC General Rules ... chronic toxicity, subchronic oral toxicity, subchronic dermal toxicity or ... conducted following an acceptable test guideline for acute inhalation toxicity, subacute inhalation toxicity or subchronic inhalation toxicity results in destruction of the respiratory tract, as ...
[DOC File]Application for the Reassessment of a Hazardous Substance ...
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Recent subchronic and acute animal studies suggest that fresh (non-aged) diesel-engine exhaust results in relatively mild inflammatory effects. The particulate phase of urban air pollution is derived in part, and until recent changes in diesel technology, largely from diesel-engine exhaust emissions.
[DOCX File]PFOA PFOS PFHxS combined Hazard Assessment
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During developmental trials for anti-neoplastic agents, the National Cancer Institute (NCI) estimates the MTDH based on the results of a progressive series of acute, subacute and or subchronic toxicological studies a battery of test animals. This work results in toxicological data in a number of animal species.
[DOCX File]About these Guidelines - AICIS | Australian Industrial ...
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The default factor for subchronic to chronic exposure is 2, and the default factor for subacute to chronic exposure is 6. Species differences. Because internal (serum) doses are compared between animals and humans, no assessment factor was used for differences in toxicokinetics, but an assessment factor of 2.5 was applied for differences in ...
[DOC File]Public Release Summary on the Evaluation of the New Active ...
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Narrative accompanying such tabular data should address the toxicological significance of the results and not repeat what is presented in the table(s).Specific guidance for acute or subchronic neurotoxicity:Indicate when and how were animals sacrificed, how many were perfused, what parameters were measured (e.g. brain weight, length and width ...
[DOC File]FF - DVA
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The main profile of this specialized laboratory is the investigation of toxicological and safety pharmacological parameters altered by acute, subacute or subchronic exposure induced by toxic agents (drugs, biotechnological preparations, medical products, environmental xenobiotics and …
[DOC File]Home page - OECD
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Acute data indicate that use of azinphos methyl is unlikely to cause significant acute adverse effects on earthworms. However, while there are no chronic data available, an acute: chronic toxicity ratio of 10 would result in a chronic risk to earthworms. Modelling for all scenarios indicated that azinphos methyl poses an acute risk to bees.
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