Acute toxicity levels
[DOC File]Title: Nicotine and Lumbriculus variegatus: Toxicity Lab
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There are 7 studies in ECOTOX encompassing 10 species that report acute toxicity values other than LC. 50 for fish and aquatic-phase amphibians. LCx toxicity endpoints range from LC 0.1 to LC 90 with values ranging from 570 to 46000 µg/L. Twenty-four other studies report lethal values (coded as NR-leth in ECOTOX) with toxicity values ranging from 26 to 60,000 µg/L.
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The Approved Criteria combines acute with chronic toxicity for some hazard categories (i.e. N51 does not exist as an individual classification). However, the GHS Classification Criteria separates acute and chronic hazard classes. Note 8: F+ - Danger: Highly Flammable; R12 - Extremely flammable (liquids) shall be translated as flammable liquid Category 1 unless it is also determined to be self ...
[DOC File]Appendix I- NCI CTC Toxicity scale
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Acute toxicity most closely correlates with the serum digoxin level. c. Hypomagnesaemia predisposes toward ( digoxin toxicity. d. Calcium chloride is the agent of choice in treatment of digoxin induced hyperkalaemia. e. 0.5 – 1.0 vials of digoxin specific Fab are required to treat life threatening digoxin toxicity when the ingested dose is unknown. 49. Phenytoin levels are increased by all ...
Toxicity of Pesticides
for acute inhalation toxicity. The study was [not] conducted in accordance with the guideline recommendations for an acute inhalation toxicity study (OCSPP 870.1300; PMRA Data Code: M4.9; OECD 403) in the [species]. DEFICIENCIES: [List each deficiency with the required data to resolve the deficiency. If no data can be provided. to. satisfy. the. deficiency, indicate. impact. on. the ...
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conducted in accordance with the guideline recommendations for an acute dermal toxicity study (EPA OCSPP 870.1200; PMRA Data Code: M4.4; and OECD 402) in the [species]. DEFICIENCIES: [If applicable, list each deficiency with the required data to. resolve. the. deficiency. or. if. no. data. can. be. provided. to. satisfy. the. deficiency.] CLASSIFICATION: [ACCEPTABLE / UNACCEPTABLE ...
[DOCX File]Guidance on the Classification of Hazardous Chemicals ...
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COMMON TOXICITY CRITERIA (NCI CTC) ... hypotension, syncope, shock) CARDIOVASCULAR (GENERAL) Acute vascular leak syndrome absent - symptomatic, but not requiring fluid support respiratory compromise or requiring fluids life-threatening; requiring pressor support and/or ventilatory support Cardiac- ischemia/infarction none non-specific T-wave flattening or changes asymptomatic, …
[DOC File]TOPIC: Histopathological Changes in Oreochromis niloticus ...
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In the TOC approach, acute lethality data are used to classify chemicals in different acute toxicity categories (TC) based on the GHS proposed by the United Nations (UN 2005) (refer to Table 1 of Grant et al. 2007). For the N-L ratio approach, acute inhalation lethality data are multiplied by a tenth percentile composite factor N-L ratio to estimate health-protective air concentrations. The ...
[DOC File]Case Study #13 – Apply AEGL Methodology to Develop Acute ...
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Lethal Dose 50, or LD50, is commonly used in measuring acute toxicity. LD50 is the dose of a given substance which is lethal to 50% of the test organisms. The information below displays the LD50 for rats and the approximate LD50 for humans for five selected chemicals: LD50 for selected Chemicals
[DOC File]TOXICOLOGY:
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The results showed that the 24-hour LC50 values are within the levels used in fishponds. Twenty four-hour (24h) LC50 are useful measures of relative acute lethal toxicity to organism under certain experimental conditions, but, these values do not represent safe concentration in natural habitats. High mortality occurred in fish showing severe gill epithelial hyperplasia, separation of the gill ...
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