Acyclovir renal adjustment

• Should cyclodextrin be used in IV formulation?

  Use IV formulation with caution if CrCl

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• Do antimicrobial doses need to be adjusted in hepatic dysfunction?

  Antimicrobial Renal Dosage Adjustment Guidelines for Adults Some antimicrobials require dose adjustment in hepatic dysfunction. Please refer to specialized references for dosing considerations. Antimicrobial doses in chart represent usual initial adult doses for moderate to severe infections due to susceptible organisms.

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• How much CrCL should I take a day after dialysis?

  HD: 1 g q24h, dose given after HD on dialysis days OR 2 g after each HD 3x/week. For bloodstream infection, 2g after first two HD sessions then 3g after dialysis Fri/Saturday CrCl 30-50: 1 g IV q8h CrCl 10-29: 1 g IV q12h CrCl < 10: 1 g IV q24h HD: Dose as CrCl

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• Can nafcillin be adjusted for renal impairment?

  Adjust based on Hartford nomogram No change for renal impairment. Hepatic Impairment: No specific dose adjustment provided by manufacturer. Dosage adjustment may be necessary in the setting of concomitant renal impairment; nafcillin primarily undergoes hepatic metabolism.

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• [PDF File]Renal Dosage Adjustment Guidelines for Antimicrobials

  https://info.5y1.org/acyclovir-renal-adjustment_1_c11f5f.html

  Renal Dosage Adjustment Guidelines for Antimicrobials The pharmacists will automatically adjust the doses of any of the antimicrobials included in the protocol according to the estimated creatinine clearance (generally using the Cockroft-Gault equation for patients ≥ 18 years old and the Schwartz equation for patients < 18 years old).

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• [PDF File]Renal Dose Adjustment Guidelines for Antimicrobials CRRT ...

  https://info.5y1.org/acyclovir-renal-adjustment_1_1bbf38.html

  reductions in residual renal function may warrant a change in dosing strategy. Residual renal function should be evaluated on a daily basis when making CRRT dosing plans. • Monitor patients for interruption of CRRT (e.g. clotting) or changing filtration rates. When CRRT is off, dose as hemodialysis patients or based on any residual renal ...

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• [PDF File]Renal Dosage Adjustment Protocol for Antimicrobials

  https://info.5y1.org/acyclovir-renal-adjustment_1_ab3996.html

  Antimicrobial Normal Dose Renal Dosage Adjustment Based on CrCl Estimate (in ml/min)* Abacavir (ABC) Adult 600 mg PO q24h or 300 mg PO q12h Pediatric 8 mg/kg PO q12h No adjustment necessary. Acyclovir Adult PO 200 mg PO 5x/day 400 mg PO 5x/day 800 mg PO 5x/day 400 mg PO q12h IV Mucocutaneous CrCl 0-10: same dose q12h

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• Antimicrobial Renal Dosage Adjustment Guidelines for Adults

  no adjustment required if on hemodialysis (ie use 1500mg x1) Osteomyelitis: 1000mg x1, repeat day 8l Doxycycline po/iv Minocycline 100mg/q12h No adjustment in renal dysfunction Gentamicin See separate chart Linezolid po/iv 600mg/q12h No adjustment in renal dysfunction Metronidazole po 500mg/q6-12h 250-500mg/ q8-12h

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• [PDF File]Stanford Health Care Antimicrobial Dosing Reference Guide

  https://info.5y1.org/acyclovir-renal-adjustment_1_05036c.html

  Acyclovir (IV) 1–7 (Use adjusted BW for obesity) CrCL > 50 CrCL 25 – 50 CrCL < 25 CrCL < 10 IHD CRRT Prophylaxis BMT 250 mg/m 2 IV q12h 125 mg/m 2 IV q12h 125 mg/m 2 IV q24h 62.5 mg/m 2 IV q24h 62.5 mg/m 2 IV q24h 125 mg/m 2 IV q12h Hematology /Oncology 2 mg/kg IV q12hq24h1 mg/kg IV Treatment General (e.g. mucocutaneous HSV ) 5 mg/kg IV

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• [PDF File]ADULT ANTIMICROBIAL DOSING GUIDELINE#

  https://info.5y1.org/acyclovir-renal-adjustment_1_b84e2d.html

  = continuous renal replacement therapy (assumes CVVHD, ultrafiltration rate 2L/h, residual native GFR < 10 mL/min). Drug CrCl > 50 mL/min CrCl 10 – 50 mL/min CrCl < 10 mL/min Dialysis (HD or CRRT) *Confirm dose with ICU or ID pharmacist Acyclovir

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