Adenosine a2a antagonist
[DOC File]RDCC
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Inhibition of monoamine oxidase B by selective adenosine A2A receptor antagonists. Bioorganic & medicinal chemistry, 11(7):1299–1310. Current projects: 1. Synthesis and evaluation of novel caffeine analogues as in vitro inhibitors of monoamine oxidase B (MAO-B) and antagonists of the adenosine A2A receptor. 2.
[DOC File]NAME OF CANDIDATE AND ADDRESS
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Roger JG, et al. Part 1: discovered and synthesized thieno[3,2-d]pyrimidine-4-methanone derivatives as antagonists of the human adenosine A2A receptor 5. Roger JG, et al. Part 2: synthesized and design 4-arylthieno [3,2-d] pyrimidine derivatives reported for antagonist of the human adenosine A2A receptor 4.
[DOC File]Rajiv Gandhi University of Health Sciences
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The adenosine A2A antagonist KF17837 reverses the locomotor suppression and tremulous jaw movements induced by haloperidol in rats: Possible relevance to parkinsonism. Behav Brain Res. 2004;148:47–54. Conceição IM, Frussa-Filho R. Effects of a single administration of buspirone on catalepsy, yawning and stereotypy in rats. ...
[DOCX File]Ahmed Nadeem, PhD - KSU Faculty
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adenosine receptors in a murine model of asthma using A2a adenosine receptor knock-out mice. Worked as . Post-doc fellow . at Department of Pharmacology, East Carolina University, Greenville, NC, USA. on characterization of A1 adenosine receptors in asthmatic and non-asthmatic human lungs and rabbits using A1 adenosine receptor antagonist
[DOCX File]Australian public assessment for naloxegol oxalate
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There were no effects on cardiac function (including coronary arterial flow and inotropic effect) in an isolated perfused rat heart model at concentrations up to 10 μM (ca 90x clinical Cmax), implying little potential for adenosine A2A receptor antagonist induced effects on cardiac perfusion under clinical use conditions.
[DOC File]cmrc.iums.ac.ir
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Journal of Gorgan University of Medical Sciences 15 (1), 12-18, 2013 2013 Effects of adenosine A2a receptor agonist and antagonist on hippocampal nuclear factor-kB expression preceded by MDMA toxicity. F Kermanian, M Soleimani, A Ebrahimzadeh, H Haghir, M Mehdizadeh. Metabolic brain disease 28 (1), 45-52
[DOC File]RESUME - KSU Faculty
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Fan M, Zhong H, Belardinelli L, Zeng D. Effect of a specific and selective A2B adenosine receptor antagonist on adenosine agonist, AMP and allergen-induced airway responsiveness and inflammation in a mouse model of asthma. J Pharmacol Exp Ther. 2007; 320:1246-51. [ISI Impact factor- 3.8]. Ansari HR, Nadeem A, Talukder MAH, Sakhalkar S, Mustafa SJ.
investors.biogen.com
in collaboration with Vernalis plc, BIIB014, formerly V2006, the lead compound in Vernalis’ adenosine A2A receptor antagonist program, which targets Parkinson’s disease and other central nervous system disorders; in collaboration with PDL, daclizumab, a humanized monoclonal antibody that binds to the IL-2 receptor on activated T cells ...
[DOCX File]Australian public assessment for lurasidone hydrochloride
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However, lurasidone was shown to have little/no affinity for histamine H1, noradrenaline (β, β1 and β2), adenosine (A1 and A2A), benzodiazepine, cholecystokinin (CCKA and CCKB), GABAA, glutamate (AMPA, kainate and NMDA), glycine, muscarinic (M1 and M2), nicotinic, opiate and sigma receptors or for calcium (L-type and N-type) or potassium ...
[DOC File]THE DIAGNOSIS AND TREATMENT OF PARKINSON’S DISEASE
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Much effort has gone in to developing non-dopaminergic agents for parkinsonian symptoms and/or dyskinesias (e.g. the adenosine A2A receptor antagonist preladenant). However, many have proved disappointing in clinical trials, perhaps because the current toxin-based animal models do not truly reflect the underlying pathophysiology of Parkinson's ...
[DOC File]Adenosin
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Adenosine inhibits IL-12 and TNF-a production via adenosine A2a receptor-dependent and independent mechanisms . The FASEB Journal. 2000;14:2065-2074.) Interleukin 12 (IL-12) is a crucial cytokine in the regulation of T helper 1 vs. T helper 2 immune responses.
investors.biogen.com
in collaboration with Vernalis plc, V2006, the lead compound in Vernalis’ adenosine A2A receptor antagonist program, which targets Parkinson’s disease and other central nervous system disorders. neublastin, a protein therapeutic that appears to maintains the viability and physiology of peripheral sensory neurons.
Stockholder Overview | Corvus Pharmaceuticals
Ciforadenant Adenosine A2A Receptor Antagonist. Ciforadenant is an oral, small molecule antagonist of the A2A receptor for adenosine that. we in-licensed from Vernalis (R&D) Limited (“Vernalis”) in February 2015. Since licensing ciforadenant, we have conducted extensive laboratory studies in vitro and in vivo in animal models to evaluate ...
[DOC File]ADDENDUM
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Inhibition of monoamine oxidase B by analogues of the adenosine A2A receptor antagonist (E)-8-(3-chlorostyryl)caffeine (CSC). Bioorganic & Medicinal Chemistry, 14 (2006) 3512–3521. Deidré van den Berg, Kevin R. Zoellner, Modupe O. Ogunrombi, Sarel F. Malan, Gisella Terre’Blanche, Jr., Neal Castagnoli, Jacobus J. Bergh and Jacobus P. Petzer
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