Agonist vs antagonist pharmacology
[DOC File]Pharmacology—Introduction and Basic Principles
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Assessment of agonist and antagonist interactions. Agonists produce direct measureable response by interacting with receptors. Antagonists block the responses elicited by agonists. COMPETITIVE ANTAGONIST competes with agonist drug for binding to receptor sites. Competitive antagonism can be overcome if dose of agonist is increased.
[DOC File]Pharmacology
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Avoid mixed agonist/antagonist in pts on full agonists-precipitate withdrawal. Do not use in patients with head injuries-depression. Chronic use during pregnancy may result in a dependent offspring. In pts with underlying respiratory dysfunction, respiratory failure can occur. Half-lives increased in patients with hepatic or renal dysfunction
[DOC File]Pharmacology - IHMC Public Cmaps (2)
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Xtampza ER® (oxycodone extended-release) is a long-acting formulation of oxycodone. Oxycodone is an opioid agonist that is relatively selective for the µ opioid receptors; although, other opioid receptor subtypes may be stimulated at higher doses.1 Stimulation of the µ opioid receptors results in analgesia, decreased gastrointestinal motility, euphoria, physical dependence, respiratory ...
[DOC File]Pharmacology Study Guide – Test 2
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Presence of antagonist increases conc of agonist required for given effect ( agonist conc-effect curve will shift to R Ratio of conc required from certain effect in presence of antagonist v. conc required in absence of antagonist is called dose ratio and is related to Kd (named Kl) of antagonist …
[DOC File]PAIN MANAGEMENT – ANALGESICS
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estrogen receptor antagonist / agonist on bone, endometrium . Uses: adjunctive therapy in certain breast CA patients, secondary prevention of breast CA in high-risk patients. BCPT trial ( tamoxifen 20 mg/d reduced by 50% risk of invasive and non-invasive breast cancer in women of all age-ranges, including prior LCIS (and now DCIS)
[DOC File]Microsoft Word - Lecture - Intro Pharm 7705.doc
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Agonist binds to opioid pain receptor in brain & causes an analgesic response. Partial agonist: binds to pain receptor and causes only limited actions. Antagonist: reverses the efx of these on pain receptors. Primarily bind to mu, kappa & delta receptors. Many opiods have …
[DOC File]PHARMACOLOGY BASIC PRINCIPLES
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Compare and contrast the pharmacology of atracurium and cisatracurium.(00j) ... Give some examples of agonist and antagonist drugs(97j) Briefly describe the pharmacological actions of the anticholinesterases with reference to edrophonium, neostigmine and the organophosphorus compounds. Indicate the similarities and differences(97m)
Agonist Vs Antagonist | Med Health Daily
Agonist vs. Antagonist. Agonist: binds/stimulates the activity of one or more biochemical receptors in the body…elicits a response. Antagonist: binds to and inhibits the activity of one or more biochemical receptors (inhibitors). Define forms of meds: Compressed: scored/shiny coat; keeps dust from forming and keeps from sticking to throat
[DOC File]Study Guide – Pharmacology Test #1
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Agonist / Antagonist. A partial agonist has affinity but low efficacy. Competitive antagonism is when an agonist and antagonist compete for the same receptor site. Non-competitive antagonism is when an agonist and antagonist bind at different sites on the same receptor. Potency vs. Efficacy. Potency is the ability of a drug to create a response.
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