Aldosterone antagonist diuretics
[DOC File]β-blockers in Heart Failure - Veterans Affairs
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K- sparing diuretics. Aldosterone antagonist ( Spironolactone. Direct acting ( Triamterene, amiloride. ADH antagonists. Lithium salts, demeclocycline. OTHERS ( Na/K acetate (Na/K bicarbonate (Na/K Acetate ( Albumin ( Dextrose. V. Diuretics. 1. General Considerations. A. These drugs promote a loss of Na+ and water from the body--increasing urine flow . B. Used for clinical management of many ...
[DOC File]Aldosterone Antagonists (Eplerenone, Spironolactone) in ...
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Diuretics: 99%. Aldosterone antagonist: 11% Mean 58 months . Primary Endpoints: 1) All-cause mortality (( with carvedilol vs. metoprolol; HR 0.83 95% CI 0.74-0.93; ARR 5.6%, NNT 18); and 2) Composite all-cause mortality or all-cause admission (HR 0.94 95% CI 0.86-1.02) Endpoint. Carvedilol (N=1511) Metoprolol (N=1518) p value . Primary1 . 512 (33.9%) 600 (39.5%) 0.017 Primary2. 1116 …
Patient assessment
If an aldosterone antagonist was initiated, serum potassium and creatinine should be checked at 3 days, 1 week, and 1 month (x 3 months) and then as needed. In addition, the medications that were prescribed for your patient’s heart failure at discharge should be reviewed and adjusted as appropriate. In particular, the need for titration of ACE inhibitors, Beta-blockers, and diuretics should ...
[DOC File]Proximal C - University of Michigan
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Finally, even though spironolactone, an aldosterone antagonist, may help maintain normokalemia after initial hypokalemia has been corrected, potassium supplements are often used instead to maintain normokalemia. Yet, the long-term effects of potassium supplements are unknown. Findings from these studies will highlight the procedural transparency and superiority of the propensity score matching ...
Aldosterone Receptor Antagonists: Diuretics for Heart Failure
In general, potassium supplements or potassium-sparing diuretics should be discontinued when therapy with a mineralocorticoid receptor antagonist is initiated. A mineralocorticoid receptor antagonist should also be used with caution in patients with a higher baseline potassium (e.g., > 4.2mEq/L), elevated serum creatinine (e.g., > 1.6 mg/dl), or receiving ACEIs7, angiotensin II receptor ...
[DOC File]Classification of diuretics
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Aldosterone Antagonist This type of medicine blocks the effects of the hormone aldosterone Aldosterone can cause the heart muscle to get bigger and …
SCA Screening Letter - Heart
Aldosterone ( upregulate H+-ATPase ( secrete more H+. Upregulate Na-K-ATPase ( Na+ reabsorption. Acidemia ( upregulate H+-ATPase ( secrete more H+. Spironolactone ( Aldosterone antagonist ( excrete Na+, Cl-, and H2O; retain K+. Inner Medullary Collecting Duct. ADH ( upregulate AQP-2 ( H2O reabsorption. upregulate UT ( Urea reabsorption
[DOC File]Role of Digoxin in Diastolic Heart Failure
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Patients with acute MI & LVD benefit from Eplerenone (an aldosterone antagonist) post MI, so you may see some patients discharged on this. 2. SYMPTOM RELIEF. in all causes of heart failure. - Loop diuretics. Diuretics are used to reduce fluid overload (oedema and pulmonary congestion) and may be reduced/stopped once on established HF treatment. Tips for increasing furosemide doses. 40mg to ...
[DOC File]Heart Failure protocol (Read Code G580) - Pennine GP Training
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Spironolactone is an aldosterone antagonist used for oedema in hepatic cirrhosis or heart failure, and primary hyperaldosteronism. Spironolactone 25mg daily has been shown to reduce mortality in patients with severe heart failure receiving standard therapy including ACE inhibitors; renal function and electrolytes should be monitored.
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