Angiotensin pathway and enzymes
[DOC File]ENDOCRINE SYSTEM - Professor Sherry Bowen
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D formation, promotes uptake of Ca from digestive tract, inhibits excretion of Ca and Mg Mineralcorticoids [aldosterone]*Renin-Angiotensin pathway adrenal cortex zona glomerulosa affects water and electrolyte balance by conserving Na …
[DOC File]Biochemistry Second Messengers
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Angiotensin II action: Gq. Increases intracellular Ca2+ which activates CaM kinase. CaM kinase and PKC phosphorylate enzymes to increase the steroidogenic pathway, increasing aldosterone levels and Na+ reabsorption. PTH release: Inhibition by Ca2+ sensitive Gq . High Ca2+ inhibits PTH release by increasing intracellular calcium via IP3/DAG/Ca2+.
[DOCX File]Angiotensin Converting Enzyme 2: A Double-Edged Sword
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Cleavage of angiotensin I by ACE generates angiotensin II, which is the primary effector peptide of the ACE/angiotensin II/AT 1 receptor axis, triggering potent vasoconstriction, inflammation, cell proliferation, hypertrophy, fibrosis, and tissue remodeling. ACE2 cleaves angiotensin II into the cardioprotective angiotensin 1–7, which acts ...
[DOC File]Biology 232 - Portland Community College
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Also regulated by renin-angiotensin-aldosterone (RAA) pathway. 1) decreased blood volume and pressure. 2) kidneys secrete renin (enzyme) into blood. 3) renin converts angiotensinogen (plasma protein from liver) into. angiotensin I. 4) enzyme in lung capillaries converts angiotensin I to angiotensin II
[DOCX File]Angiotensin Converting Enzyme 2: A Double-Edged Sword
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leading to another pathway for ACE2 loss from SARS–CoV-2–induced systemic and tissue inflammation. In lung injury, deregulation of RAS through downregulation of ACE2 increases vascular permeability, pulmonary edema, and severity of injury in SARS-CoV infections though actions of angiotensin II that are attenuated by AT. 1. receptor blockade.. In postmortem …
[DOC File]Physiology Lecture Outline
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As we will see later, angiotensinogen is an important precursor to angiotensin I and II. Other enzymes require cofactors or coenzymes associated with the enzyme in order for the enzyme to function properly. 2. Cofactors - are inorganic, non protein components required for substrate binding at the active site. ... All tissues have the pathway ...
[DOC File]Biochemistry Objectives 48
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Excess angiotensin II: problem with the mineralocorticoid receptor, and subsequent increase in mineralocorticoid release (via angiotensin II) Steroids eliciting: Virilization: glucocorticoid receptor defect, 21-hydroxylase, 11(-hydroxylase, and mildly with 3(OH-SD or (5,4-isomerase (any pathway that diminishes cortisol production but leaves a ...
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