Anti pdl1 drugs
First Anti-PD-L1 Drug Approved for NSCLC.
TG-1501 (anti-PDL1 monoclonal antibody) Pursuant to our Global Collaboration with Checkpoint Therapeutics, we have the exclusive commercial rights in the treatment of hematological cancers and autoimmune diseases to a series of patent applications pending in the United States, Australia, Canada, Europe, Israel and Korea.
[DOCX File]Summary of PICO - Department of Health
https://info.5y1.org/anti-pdl1-drugs_1_8ef91b.html
Bioconjugation of cargoes on cell membranes is an alternative approach [140]. To improve tumor-targeting efficiency of anti-PDL1 and reduce its off-target effects, Wang et al. developed platelets conjugated with anti-PDL1 (P-aPDL1) that could move directionally to the surgical site for inhibiting post-surgical tumor recurrence [141].
[DOC File]Theranostics
https://info.5y1.org/anti-pdl1-drugs_1_51f2d3.html
Roche has recently announced three phase 3 trials (GO29436, GO29537, GO29437) combining their anti-PDL1 (in patients with advanced squamous NSCLC comparing the combination of Roche’s anti-PD-L1 MPDL3280A with paclitaxel or albumin-bound paclitaxel in various combinations with carboplatin (with or without bevacizumab).
TG Therapeutics, Inc.
Three other monoclonal antibodies have been used to develop commercial anti-PD-L1 IHC tests: Ventana rabbit SP142; Dako rabbit 28-8; Dako mouse 22C3. Results obtained with each of these and SP1263 (largely in NSCLC) have been observed to be highly variable and have been the subject of a number of concordance studies.
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