Apixaban guidelines

• Scenario: Apixaban | Management | Anticoagulation - oral ...

  Apixaban has the least renal excretion of any NOAC. A multi-dose study in dialysis patients indicated that a dose of apixaban 2.5mg twice daily resulted in a predicted drug exposure equivalent to a 5mg twice daily dose in subjects with normal renal function6-8 Target apixaban trough levels appear to be a median of 80 to 100ng/mL for atrial fibrillation (95% range 41 to 230 ng/mL) and 63 (95% ...

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• [DOCX File]New Guidance for use of Dabigatran, Apixiban and ...

  https://info.5y1.org/apixaban-guidelines_1_055bd7.html

  Apixaban is 50% bioavailable and exhibits linear pharmacokinetics across the approved dose range. The time to peak plasma concentration (T max) is at 3 to 4 hours and it is 87% plasma protein bound. Apixaban is mainly metabolized by cytochrome P450 isozyme CYP3A4, is a substrate of P-glycoprotein and breast cancer receptor protein (BCRP).

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• [DOCX File]Australian public assessment forApixaban

  https://info.5y1.org/apixaban-guidelines_1_55467f.html

  New Guidance for use of Dabigatran, Apixaban and Rivaroxaban for patients with AF undergoing DC Cardioversion. Introduction. Dabigatran, apixaban and rivaroxaban (the so called novel oral anticoagulants or NOACs) are all NICE approved licensed alternatives to warfarin for stroke prevention in patients with non-valvular Atrial Fibrillation (AF).

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• [DOCX File]Apixaban Use in Adults with Severe Kidney Disease

  https://info.5y1.org/apixaban-guidelines_1_2f8e1d.html

  Apixaban is a reversible, direct and highly selective inhibitor of FXa. It does not require antithrombin III for antithrombotic activity. Apixaban inhibits free and clot-bound FXa, and prothrombinase activity. Apixaban has no direct effects on platelet aggregation, but indirectly inhibits platelet aggregation induced by …

  apixaban dosing guidelines

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