Apixaban loading dose
Oral Anticoagulation Management Guidelines
Separate protocols are available 4 policy regarding the management of the direct oral anticoagulants apixaban, dabidatran, edoxaban and rivaroxaban. Target Audience. Trust Medical Staff. Trust Nursing staff. Nursing staff in anticoagulant clinics. Accident and emergency Staff. Pharmacists involved in the management of patients on oral ...
[DOC File]2: Cardiovascular system
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For rapid rate control in atrial fibrillation, a loading dose of digoxin may be given intravenously or orally. Regular measurements of plasma digoxin concentrations are not usually required except to confirm toxic or sub-therapeutic levels, or to check compliance. ... Apixaban 2.5mg tablets and 5mg tablets - not a preferred option in the ...
[DOCX File]Anticoagulation Therapeutic Management (Adults only)
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A loading dose is administered from the standard bag using the bolus function in the Braun infusion pump. Refer to Table 2 – Heparin Administration for further information on how to do this. Pre-mix bag changes are also recorded by two nurses on the Heparin Intravenous Infusion Order and Administration Chart – Adult pre-mix bag set up section.
[DOCX File]Anticoagulation Management
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For high BMI, dose reduction may be required based on measured anti-Xa levels, aiming for a 4 hour post dose level of 0.5-1units/mL (twice daily dosing) or 0.5-1.5units/mL for daily dosing. * For use in haemodialysis and other extracorporeal procedures, see specific procedural policies.
[DOCX File]Anticoagulation Management - | Health
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For high BMI, dose reduction may be required based on measured anti-Xa levels, aiming for a 4 hour post dose level of 0.5-1units/mL (twice daily dosing) or 0.5-1.5units/mL for daily dosing. * For use in haemodialysis and other extracorporeal procedures, see specific procedural policies.
[DOCX File]Introduction
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Generally ticagrelor & aspirin (loading doses 180 mg and 300 mg respectively) Sometimes you will see clopidogrel (300 mg loading dose, then 75 mg OD). This is generally used when the patient is already on an anti-coagulant. Prasugrel – if patient not tolerant to other agents. Nitrates. GTN spray
[DOCX File]Australian public assessment report forApixaban
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The oral bioavailability of apixaban was similar when co-administered with prasugrel given as a 60 mg loading followed by 10 mg daily for 4 days. Although the AUC was similar there was a 12% reduction in the C max of prasugrel. However, 90% of subjects had more than 50% inhibition in platelet aggregation after the loading dose.
[DOC File]TEMPLATE
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A loading dose of . 5 mg. orally is given. Use of larger loading doses (e.g. 10 - 30 mg) simply . increase the incidence of haemorrhage. and other complications, without offering a more rapid protection against thrombi formation, and is not recommended.
[DOCX File]www.myharrisregional.com
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apixaban (Eliquis) ~12 hours. Mainly hepatic with 27% renal ... Antiplatelet effects begin within one hour of dose and persist for at least 4 days after stopping therapy. ... More rapid inhibition of platelet function is achieved with loading doses; antiplatelet effect lasts up to 10 days after stopping therapy. Prasugrel (Effient) 30 min . 7 ...
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