Atovaquone proguanil vs chloroquine
[DOC File]Al al-Bayt University
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C. Atovaquone–proguanil. The combination of atovaquone–proguanil is effective for chloroquine-resistant strains of P. falciparum, and it is used in the prevention and treatment of malaria. Atovaquone. inhibits mitochondrial processes such as electron transport, as well as ATP and pyrimidine biosynthesis.
[DOCX File]Executive Summary - Veterans Affairs
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The FDA approval of atovaquone/proguanil in 2000 relied on clinical studies performed in malaria-endemic areas where study subjects were presumed to partially immune to malaria as described in Table 2. The prophylactic efficacy of atovaquone/proguanil in non-immune subjects was not well-studied.
[DOCX File]Attachment: Extract from Clinical Evaluation: Tafenoquine
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Atovaquone/proguanil (Malarone) prophylaxis should begin 1 to 2 days before travel to malarious areas and should be taken daily, at the same time each day, while in the malarious areas and, since this agent is causally-active, daily for 7 days after leaving the area.2 Malarone prophylactic efficacy is approximately 98%.
[DOC File]DMID Protocol Template - ResearchGate
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Atovaquone/proguanil (Malarone®) is a very well tolerated pharmaceutical agent that is relatively new to the market and is the second-line agent for chloroquine sensitive parasites.
[DOC File]P
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Atovaquone - Proguanil (Malarone) ... Thus, for each clone, groups of mice were each inoculated intraperitoneally with 1x106 parasites (day 0). Chloroquine at 3 mg/kg/day, mefloquine at 4 mg/kg/day or 6 mg/kg/day, lumefantrine at 3 mg/kg/day and artemisinin at 50 mg/kg/day or 100 mg/kg/day were given to “treated” groups, daily from day 1 ...
[DOC File]Se .br
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For example, to evaluate the efficacy of the combination atovaquone and proguanil for the treatment of malaria (in comparison with amodiaquine) a sample size was calculated in order to estimated a difference between a possible 90% negative parasitaemia in the experimental group vs. 65% in the amodiaquine group at day 28.
[DOC File]DMID Protocol Template - ResearchGate
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A longitudinal study of chloroquine as monotherapy or in combination with artesunate, azithromycin or atovaquone-proguanil to treat malaria in children in Blantyre, Malawi Funding Mechanism: U01 ...
[DOC File]Supplementary methods - ResearchGate
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Chloroquine administered in saline solution at 1, 2, and 4 mg/kg p.o. every 24 h was included as control of efficacy. All compounds and control vehicles were administered orally in …
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