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[DOC File]АНТИНУКЛЕАРНИ АНТИТЕЛА -КЛИНИЧНО ЗНАЧЕНИЕ
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The first-grade relatives of patients with autoimmune diseases have more often positive ANA test (6). ANA are detected in patients with chronic HCV-infection, where they are often associated with rheumatological symptoms - joint pain and swelling, purpura, and with increase of aspartate aminotransferase, alpha-fetoprotein, alkaline phosphatase ...

[DOCX File]ANA Testing Pathology Quick Guide
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A positive ANA in a patient who you do not think has SLE and who only has 1 of the diagnostic symptoms is most likely to be a NON-SPECIFIC FINDING. ANA alone has a low positive predictive value for SLE so it is unlikely to be useful in patient populations with a low prevalence of systemic lupus erythematosus (e.g. the elderly).

Table S2: Cytoplasmic HEp-2 patterns (further details)
Autoantibodies to non-muscle myosin have been described in 3 patients with HCV-positive chronic hepatitis/liver cirrhosis ... Fritzler MJ, Choi MY, Mahler M. The anti-nuclear antibody (ANA) test in the diagnosis of anti-synthetase syndrome and other autoimmune myopathies (AIM). ... Van den Bergh K, Blockmans D, et al. Anti-Golgi autoantibodies ...

Ohio University
While some autoimmune diseases involve immune weapons against only one cell type or tissue (like immune thrombocytopenic purpura or ITP in which autoantibodies against platelets leads to thrombocytopenia), lupus is a multisystem disease; multisystem in this context means that there are several cells, tissues, organs, or organ systems that are ...

[DOC File]2002
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Other autoimmune diseases, viral infections, chronic inflammatory processes, and several drugs induce ANAs. Therefore, a positive ANA test supports the diagnosis of SLE but is not specific; a negative ANA test makes the diagnosis unlikely but not impossible.

[DOC File]R
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To detect specific pattern of staining of ANA with positive screening test. To assess the usefulness of IF technique as a screening procedure for various connective tissue disorders like RA, SLE, Sjogrens disease, Systemic sclerosis, Drug induced lupus(DLE), Hashimotos disease, Graves disease.

[DOC File]etiology – studying cause or origin of disease
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Genetic correlations have been attributed to androgenetic alopecia while autoimmune diseases have some linkage to alopecia areata. Unfortunately, positive treatment outcomes are still sporadic with little few breaking developments in the fields.

[DOC File]Pathology
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The antinuclear antibody test, ANA test, is positive for many connective tissue diseases but is more specific for SLE when the antinuclear antibodies react with double-stranded DNA. Microscopically this appears as a characteristic peripheral nuclear staining or “rim” pattern.

[DOC File]www.pch-pathlab.com
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Specificity 100% for autoimmune myositis. 24-30% sensitivity (18-46% for polymyositis) in adults. Seldom found in children. Most myositis patients with Jo-1 have anti-synthetase syndrome (ASS) which has 60% sensitivity. Ku Nuclear fine speckled. Non-specific but exclusively found in systemic autoimmune conditions often of an overlap nature.

[DOC File]Anti-ssDNA Is Not a Useful Diagnostic Test
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Although kits are available for anti-ssDNA and some laboratories offer this testing, it is not useful in the diagnosis of specific autoimmune diseases and is not mentioned as being part of the testing that should be done as a follow-up to a positive ANA in the new Guidelines.

[DOC File]Lupus erythematosus
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SLE is one of several diseases known as "the great imitators. because its symptoms vary so widely it often mimics or is mistaken for other illnesses, and because the symptoms come and go unpredictably. ... (which usually occurs in hemorrhagic disorders) and a positive test for antiphospholipid antibodies with anticardiolipin may be positive and ...

[DOC File]PCB 4233C Immunology
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Autoimmune disease Ch 11. ANA Assay Discuss the mechanisms and consequences of the four primary types of hypersensitive reactions. Describe the principal mediators involved in the four primary types of hypersensitivities. Discuss the timing of the reaction in the types of hypersensitivity reactions.

[DOC File]Diabetes - Stanford University
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ANA pattern Nuclear antigen Clinical associations Homogeneous/diffuse Histone/DNA SLE, drug effect Speckled Various MCTD, SLE, Sjögren’s, poly-/dermatomyositis, various autoimmune diseases, infection, neoplasia Nucleolar RNA-associated antigens Scleroderma Peripheral (rim) DNA SLE Centromere Centromere Limited scleroderma

Autoimmune diseases with positive ana