Benzyl alcohol toxicity in neonates
[DOCX File]ADOLIN 0.1% CREAM AND GEL
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Central nervous system toxicity is a graded response with symptoms and signs of escalating severity. The first symptoms are circumoral paraesthesia, numbness of the tongue, light-headedness, hyperacusis and tinnitus. ... Benzyl alcohol (preservative): 1%m/m. Properties. ... One PK study was conducted in 9 full-term neonates (mean age: 7 days ...
[DOC File]PLEASE REFER TO ANZFA’S GUIDE TO APPLICATIONS AND ...
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A limited number of reproductive and developmental toxicity studies with benzyl alcohol, benzyl acetate, benzyl aldehyde and sodium benzoate are available which have been reviewed by both JECFA and the SCF (WHO 1997, WHO 2001, SCF 2002).
[DOCX File]PAEDIATICS MCQ
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in neonates the should be 120 chest compressions per minute with a 3:1 ratio with breaths ... 20-60 may need chelation, 60-90 high risk of toxicity. a.Xray will show tablets in 80% of patients. False – 50% by tintanelli. b.Must wait for all lab results and TIBG before commencing desferoxamine – TIBG is useless – treat based on clinical ...
[DOC File]SPC 764924 Haloperidol ENG.doc
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Benzyl alcohol. Chlorobutanol hemihydrate. Lactic acid for pH regulation. Water for injections . 6.2 Incompatibilities. No not known. 6.3 Self life. 5 years. 6.4 Special precautions for storage. Do not store above 25 °C. Store in the original packaging in order to protect from …
[DOCX File]Veterinary Medicines Directorate
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Benzyl Alcohol (preservative) Benzyl alcohol toxicity may lead to prolonged recovery and hyperkinesia in cats, and neurological signs such as tremors in dogs and fatalities in both species. There is no specific antidote; supportive treatment should be given.
[DOCX File]Form for submission of comments - EFPIA
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As benzyl alcohol can produce nonimmunologic contact urticaria and nonimmunologic immediate contact reactions, characterized by the appearance of wheals, erythema, and pruritis, likely involving a cholinergic mechanism, it was concluded that these ingredients could be used safely at concentrations up to 5%, but that manufacturers should consider the nonimmunologic phenomena when using these …
[DOCX File]Rate of Administration
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Large amounts of benzyl alcohol (e.g., 100–400 mg/kg daily) have been associated with toxicity in neonates; each mL of amiodarone hydrochloride injection contains 20.2 mg of benzyl alcohol…
[DOC File]Pharmacy Benefits Management Services Home
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Benzyl alcohol toxicity: Spinosad topical suspension contains benzyl alcohol and is not recommended for use in neonates and infants under the age of 6 months. Systemic exposure to benzyl alcohol has been associated with serious adverse reactions, including “gasping syndrome,” and death in neonates and low birth weight infants.3
[DOC File]NURSE PROTOCOL FOR
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Use fine-toothed comb to remove lice and eggs from hair, shampoo hair to restore body and luster. Repeat application in 7-10 days. A-200 may be preferred because its benzyl alcohol base has pediculosidal activity. OR. 3. For resistance to permethrin and pyrethrins which is becoming increasingly common in the US: Malathion (e.g., prescription ...
[DOC File]Center for Drug Information and Pharmacy Practice1, ABDA ...
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120. Hiller JL, Benda GI, Rahatzad M, Allen JR, Culver DH, Carlson CV et al.: Benzyl alcohol toxicity: impact on mortality and intraventricular hemorrhage among very low birth weight infants. Pediatrics 1986, 77: 500-506. 121. Lopez-Herce J, Bonet C, Meana A, Albajara L: Benzyl alcohol poisoning following diazepam intravenous infusion.
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