Cardiac hypertrophy
ERK: A Key Player in the Pathophysiology of Cardiac Hypertrophy
hemodynamic, and neurohumoral signals, lead to cardiac hypertrophy. In fact, the increase in cardiac muscle mass and force produces beneficial e ects aiming to normalize wall stress and preserve cardiac output while blood filling is impaired. Pressure overload usually results in concentric hypertrophy
Glucose Metabolism in Cardiac Hypertrophy and Heart Failure
Glucose Metabolism in Cardiac Hypertrophy and Heart Failure Diem H. Tran PhD; Zhao V. Wang, PhD H eart failure is one of the leading causes of death worldwide and has been singled out as an emerging epidemic.1,2 With a 5-year survival rate of 50%, heart failure
[PDF File]PDF Is Cardiac Hypertrophy Good or Bad? - JACC Imaging
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Is Cardiac Hypertrophy Good or Bad? The Answer, Of Course, Is Yes* Blase A. Carabello, MD I nthisissueofiJACC,Petrovetal.(1) examined patterns of hypertrophy in patients with aortic stenosis. They found that women had"adap-tive" hypertrophy more often than men, but when women had "maladaptive" hypertrophy, their mor-
[PDF File]PDF Resistance Training and Cardiac Hypertrophy
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Resistance Training and Cardiac Hypertrophy Unravelling the Training Effect Mark J. Haykowsky,1,2 Rudolph Dressendorfer, 1 Dylan Taylor,2 Sandra Mandic 1 and Dennis Humen3 1 Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada
[PDF File]PDF ACVIM Fact Sheet: Hypertrophic Cardiomyopathy in Cats Overview
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hypertrophy is mild and focal, the cat may remain symptom-free for all his life. However, if the hypertrophy is severe, the ventricle will have a hard time distending, which leads to increased intra-cardiac pressure and congestive heart failure (CHF) with fluid build-up in or around the lungs.
[PDF File]PDF Pregnancy-Associated Cardiac Hypertrophy in Corin-Deficient ...
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preeclampsia and cardiac hypertrophy. The objective of this study was to investigate the role of corin and the T555I/Q568P variant in preeclampsia-associated cardiac alterations using genetically modified mouse models. Methods: Virgin wild-type (WT) and corin knockout mice with or without a cardiac WT corin or T555I/Q568P variant transgene were
[PDF File]PDF Eccentric and concentric cardiac hypertrophy induced by ...
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eccentric cardiac hypertrophy induced by exercise training. We also describe the involvement of the angiotensin II type I (AT1) receptor and of the microRNAs (miRs) in different forms of cardiac hypertrophy. Concentric cardiac hypertrophy induced by resistance training In static or isometric physical exercise (e.g., weight lifting,
[PDF File]PDF Histone deacetylase (HDAC) inhibitors attenuate cardiac ...
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afterload-induced cardiac hypertrophy/failure triggered by tight banding of the aorta and that this load-induced autophagic re-sponse is maladaptive, contributing to disease pathogenesis (13). To examine further the role of cardiomyocyte autophagy in pathological cardiac remodeling, we used a model of moderate
[PDF File]PDF Cardiac hypertrophy and thyroid hormone signaling
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cardiac hypertrophy to a normal cardiac configuration. In addition, less well recognized effects of thyroid hormones are exerted on the cardiac vascular system with a promo-tion of angiogenesis [8, 9]. Increased thyroid hormone action leads to a decrease of the tone of arterial vascular smooth muscle and a markedly decreased cardiac afterload ...
[PDF File]PDF Cardiac Hypertrophy: A Review on Pathogenesis and Treatment
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Cardiac hypertrophy has been considered as an important risk factor for cardiac morbidity and mortality whose prevalence has increased during the last few decades. Cardiac hypertrophy, a disease associated with the myocardium, is characterized
[PDF File]PDF VA Form 21-0960A-4 Non-Ischemic Heart Disease (Including ...
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NOTE: For coronary artery disease, myocardial infarction, or hypertensive disease, complete VA Form 21-0960A-1, Ischemic Heart Disease Disability Benefits Questionnaire. SECTION I - DIAGNOSIS. HEART CONDITIONS (INCLUDING ISCHEMIC AND NON-ISCHEMIC HEART DISEASE, ARRHYTHMIAS, VALVULAR DISEASE AND CARDIAC SURGERY)
Cardiac Hypertrophy in Obstructive Sleep Apnea Syndrome
ular hypertrophy in OSAS has not been established. We hypothesized that the presence of cardiac hy pertrophy was related to the severity of OSAS, an
Soluble epoxide hydrolase inhibitor, TUPS, protects ...
cardiac hypertrophy can lead to systolic and diastolic cardiac dysfunction and ultimately heart failure (Levy et al., 1994). Heart failure is a deadly cardiovascular disease that affects more than 23 million worldwide and more than 5 million
Angiogenesis and Cardiac Hypertrophy
Cardiac hypertrophy in normal growth or in trained athletes is referred to as physiological hypertrophy and is character-ized by normal or enhanced contractile function and normal architecture and organization of cardiac structure. 4 In contrast, cardiac hypertrophy in patients with hypertension, myocardial
[PDF File]PDF Cardiac hypertrophy is with
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c-mycexpression in cardiac myocytecultures. Thesefrdings show that the induction of cardiac myocyte hypertrophy is associated with enhanced expression of the c-myc gene and suggest that hormonally induced cell hypertrophy and cell division share commonmechanistic pathways. Tissues grow by two processes: an increase in cell size
[PDF File]PDF A Redox-Dependent Pathway for Regulating Class II HDACs and ...
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A Redox-Dependent Pathway for Regulating Class II HDACs and Cardiac Hypertrophy Tetsuro Ago,1 Tong Liu,2 Peiyong Zhai,1 Wei Chen,2 Hong Li,2 Jeffery D. Molkentin,3 Stephen F. Vatner,1 and Junichi Sadoshima1,* 1Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and
[PDF File]PDF Potential Markers in Cardiac Hypertrophy - Ifcc
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POTENTIAL MARKERS IN CARDIAC HYPERTROPHY? POTENTIAL MARKERS IN CARDIAC HYPERTROPHY? Bartosz Malinowski 1,2, Gabriele Fulgheri 1, Michal Wicinski 2, Elzbieta Grzesk 2, Grazyna Odrowaz‐Sypniewska 1, Grzegorz Grześk 2, Nasser Darwish2 1Department of Laboratory Medicine, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
Blood pressure and cardiac hypertrophy - Deep Blue
Blood pressure and cardiac hypertrophy 1331 closed layer by layer with 5-0 silk sutures. For sham-operated mice, silk sutures were passed under aortas and then removed; therefore no constrictions to aortas were performed (n=3forsham and 27G groups, n = 4 for 25G and 26G groups). Direct measurement of POL by radiotelemetry.
Isoproterenol-induced cardiac hypertrophy: role of ...
thesis in cardiac myocytes (15), in vivo both a- and b-receptor stimulation induces cardiac hypertrophy (19). There is some evidence that trophic responses to cardiac sympathetic stimulation in vivo depend on the (cardiac) RAS. Chronic infusion of norepinephrine, even in subpressor doses, causes cardiac hypertrophy in rats and dogs (16, 19).
[PDF File]PDF Cardiac Nuclear High-Mobility Group Box 1 Ameliorates ...
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Cardiac hypertrophy was induced in 10- to 12-week-old mice with cardiac-specificover-expression of HMGB1 (HMGB1-Tg) and their wild-type (WT) littermates by chronic infusion of Ang II (1.5 mg/kg/day) or saline as previously described(23).
Cardiac hypertrophy elevates serum levels of fibroblast ...
Cardiac hypertrophy elevates serum levels of fibroblast growth factor 23 see commentary on page 7 Isao Matsui1, Tatsufumi Oka1, Yasuo Kusunoki2, Daisuke Mori1, Nobuhiro Hashimoto1, Ayumi Matsumoto1, Karin Shimada1, Satoshi Yamaguchi1, Keiichi Kubota1, Sayoko Yonemoto1, Tomoaki Higo3, Yusuke Sakaguchi4, Yoshitsugu Takabatake1, Takayuki Hamano4 and Yoshitaka Isaka1
Mechanisms of Cardiac Hypertrophy
Mechanisms of Cardiac Hypertrophy Giulio Selvetella, MDa, Giuseppe Lembo, MD, PhDa,b,* aIRCCS Neuromedicine, Pozzilli, Italy b''La Sapienza'' University of Rome, Rome, Italy Cardiac hypertrophy is a response of myocardium to various physiologic and pathologic stimuli, me-
Cardiac Hypertrophy: Useful Adaptation or Pathologic Process?
of cardiac hypertrophy in patients with chronic pres- sure-overload or volume-overload of the left ventricle. In this regard, Grant and co-workers [4] studied a series of patients with cardiac hypertrophy from various causes and observed that volume-overload or eccentric
Cardiac Hypertrophy: A Risk Factor for QT-Prolongation and ...
Cardiac Hypertrophy: A Risk Factor for QT-Prolongation and Cardiac Sudden Death Y. J AMES KANG Departments of Medicine, Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA ABSTRACT Cardiac hypertrophy was viewed as a compensatory response to hemodynamic stress.
[PDF File]PDF CARDIAC HYPERTROPHY: The Good, the Bad, and the Ugly
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Abstract Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic stimuli that impose increased biomechanical stress. While hypertrophy can
Consequence of Cardiac Hypertrophy
cardiac hypertrophy is secondary to thyrotoxicosis [ 121 or when pressure-induced hypertrophy is produced "in utero" [ 131. Thus, in some animal models of disease, coronary reserve is well preserved in the presence of cardiac hypertrophy. The three boxes at the bottom of Figure 1 illustrate
[PDF File]PDF cardiac hypertrophy, fibrosis, and diastolic Fibroblast ...
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pathogenesis of cardiac disease, including cardiac hypertrophy and fibrosis, there is increasing evidence that cardiac fibroblasts (CFs), the most abundant cell type in the mammalian heart, could also play an important role in mediating cardiac hypertrophy and remodeling (16-18). However, the role of ROCK2 in
Regulation of Cardiac Hypertrophy by mAKAP-Anchored RSK3
Regulation of Cardiac Hypertrophy by mAKAP-Anchored RSK3 (June 2013) Abstract of a dissertation at the University of Miami. Dissertation supervised by Professor Michael Seth Kapiloff. No. of pages in text. (91) ERK MAP-kinases regulate the concentric growth and survival of cardiac myocytes.
Hypertension, Cardiac Hypertrophy, and Impaired Vascular ...
cardiac hypertrophy, which may be mediated, in part, by increased superoxide. Keywords Aryl hydrocarbon receptor Cardiac hypertrophy Endothelial dysfunction Hypertension Superoxide TCDD Introduction 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a ubiqui-tous toxicant that persists in the environment and is generally resistant to degradation.
[PDF File]PDF Shared Genetic Causes of Cardiac Hypertrophy in Children and ...
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The new engl and journal of medicine original article Shared Genetic Causes of Cardiac Hypertrophy in Children and Adults Hiroyuki Morita, M.D., Heidi L. Rehm, Ph.D., Andres Menesses, M.D.,
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