Causes of unconjugated hyperbilirubinemia
[DOC File]2005-04-25
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The reason for hyperbilirubinemia (and jaundice in some cases) is that the hemolysis of RBCs results in the formation of too much bilirubin for the liver to process and excrete into the bile ducts; thus, the unconjugated or indirect bilirubin “backs up” in the blood;
[DOC File]MENNONITE COLLEGE OF NURSING
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Two types of bilirubin: Fractionated into unconjugated and conjugated Un conjugated (free bilirubin floating around in the bloodstream; free floating bilirubin is toxic to the body): prior to hepatic conjugation (attached to the modified glucose to make it more water soluble); insoluble in water
What causes unconjugated hyperbilirubinemia?
Unconjugated hyperbilirubinemia. 1-Breast milk jaundice: The patient is usually well.2% of infants get the problem after the 7th day of life, maximum concentration is 10-30mg/dl reached during 2nd-3rd week.No signs of other illnesses,kernicterus has been reported but it is rare. Needs no treatment but phototherapy may be of help..
[DOC File]Gastroenterology - Stanford University
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2. Unconjugated bilirubin-- the fat-soluble form. Produced when hemoglobin is broken down, usually in the liver. This is the most common which we discussed earlier in the semester. 3. Common causes of Hyperbilirubinemia. a. Polycythemia of the newborn (Hct > 65% at birth) b. Enclosed hemorrhage (cephalhematoma, large bruises) c. UTI, sepsis
[DOCX File]Indiana University Bloomington
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A liver biopsy showed severe bile duct cholestasis with no inflammation. Based on the exclusion of other potential causes of hyperbilirubinemia and the fact that both instances of increased bilirubin occurred after ERCP and MRCP, the contrast agents iopromide and gadoterate meglumine were suspected to be the causes of the hyperbilirubinemia.
[DOC File]RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES, KARNATAKA
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unconjugated hyperbilirubinemia. hemoglobinemia. hemoglobinuria. haptoglobin. Gilbert syndrome. Dubin-Johnson syndrome. Table 15-3: Main causes of jaundice. Instrinsic (intracorpuscular) hemolysis. ... Common causes of massive, moderate and mild splenomegaly: page 456 Basic Robbins. Thymus.
Clinical Medicine 9-22-16 1st Hour: Hepatobiliary
This extreme hyperbilirubinemia is due to combination of hemolysis causing unconjugated hyperbilirubinemia, and intrahepatic cholestasis and renal impairment contributing to the conjugated component. Transaminase levels above 1000 mg/dL are commonly seen.
ohioopen.library.ohio.edu
Isolated hyperbilirubinemia. Indirect hyperbilirubinemia, >85% of total bilirubin is unconjugated. Total bilirubin usually never >6 mg/dL in hemolysis. Check reticulocyte count and hemolysis labs . Direct hyperbilibinemia, >50% of total bilirubin is conjugated. Causes of indirect hyperbilirubinemia. Hemolysis. Ineffective erythropoiesis
[DOC File]Neonatal jaundice:Jaundice is the most common clinical ...
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Hyperbilirubinemia may lead to neurotoxicity and neuronal death. The mechanisms of nerve cell damage by unconjugated bilirubin (UCB) appear to involve a …
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