Cerebral hypoperfusion causes

    • [PDF File]Attenuating vascular stenosis-induced astrogliosis ...

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      Background: Chronic cerebral hypoperfusion (CCH) causes white matter damage and cognitive impairment, in which astrogliosis is the major pathology. However, underlying cellular mechanisms are not well defined. Activation of Na+/H+ exchanger-1 (NHE1) in reactive astrocytes causes astrocytic hypertrophy and swelling. In this study, we


    • The neuropathology and cerebrovascular

      vascular disease and cerebral hypoperfusion asso-ciated with neuronal injury, structural and functional brain damage.7 More specifically, neuroimaging find-ings indicate white matter hyperintensities, cerebro-vascular lesions, and cerebral amyloid angiopathy (CAA).8 Other ultrastructural abnormalities to the


    • [PDF File]A Clinical Example of the “Limping Brain” Syndrome: A Case ...

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      Cerebral hypoperfusion that causes neurologic def-icits lasting 24 hours is invariably associated with infarction on brain imaging. We present the case of a patient with persistent aphasia that fluctuated over 1 week, left middle cerebral artery (MCA) stenosis, and hypoperfusion of the left MCA territory documented



    • [PDF File]Hypocapnic cerebral hypoperfusion: A biomarker of ...

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      Cerebral hypoperfusion in OI can be related to hypocapnia which causes cerebral vasocon- striction and reduces cerebral blood flow. This mechanism, e.g. hypocapnic cerebral hypoper-


    • [PDF File]AUTONOMIC DISEASES: CLINICAL FEATURES AND LABORATORY ...

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      low cerebral perfusion pressure without symptoms, presum-ably because of improved cerebrovascular autoregulation. In some, a relatively small fall in blood pressure may induce cerebral hypoperfusion, especially in the presence of cerebro-vascular disease. A variety of symptoms result from hypoperfusion of other organs.


    • [PDF File]Presentation of transient loss of consciousness Definition ...

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      o Syncope: transient loss of consciousness due to global cerebral hypoperfusion caused by hypotension secondary to a fall in cardiac output (CO) or systemic vascular resistance (SVR) o Seizure: episode of abnormal electrical activity in the brain List three main causes of syncope o Reflex/neural o Orthostatic hypotension o Cardiac


    • [PDF File]Approach 1,2* Hypoperfusion: A Multimodal and Longitudinal ...

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      Cerebral hypoperfusion induced by bilateral common carotid artery occlusion (BCCAo) in rodents has been proposed as an experimental model of white matter damage and vascular dementia. However, the histopathological and behavioral alterations reported in this model are variable and a full characterization of the dynamic alterations is not available.


    • [PDF File]Deficiency of Nrf2 exacerbates white matter damage and ...

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      Background: Chronic cerebral hypoperfusion causes damage to the brain’s white matter underpinning vascular cognitive impairment. Inflammation and oxidative stress have been proposed as key pathophysiological mechanisms of which the transcription factor Nrf2 is a master regulator. We hypothesised that white matter


    • Propofol improves brain injury induced by chronic cerebral ...

      Chronic cerebral hypoperfusion (CCH) is one of the main causes of the occurrence and development of mild cognitive impairment (MCI) (Kume etal., 2011; Staffen et al.,2006), vascular dementia


    • [PDF File]Hypoperfusion, Mitochondria Failure, Oxidative Stress and ...

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      hypoperfusion, these are key factors in impaired tissue oxygen delivery and therefore appear to be main reason for the development of AD. Importantly, the reduced energy production found in hypoperfusion may lead to energy failure. This failure ul-timately manifests itself as damage to mitochondrial ul-


    • [PDF File]Compression syndromes caused substernal goitres

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      rare causes include decompensatedright-sided congestive heart failure, pleural effusion, and pulmonary hypoperfusion due to compression of pulmonary arteries.'4 17 18


    • [PDF File]Causes and consequences of baseline cerebral blood flow ...

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      Review Article Causes and consequences of baseline cerebral blood flow reductions in Alzheimer’s disease Oliver Bracko1, Jean C Cruz Herna´ndez2, Laibaik Park3, Nozomi Nishimura1 and Chris B Schaffer1 Abstract Reductions of baseline cerebral blood flow (CBF) of 10–20% are a common symptom of Alzheimer’s disease (AD) that


    • Orthostatic Cerebral Hypoperfusion Syndrome

      lying pathophysiology is poorly understood. This study describes orthostatic cerebral hypoperfusion syndrome (OCHOs). OCHOs is defined by (1) abnormal orthostatic drop of cerebral blood flow velocity (CBFv) during the tilt test and (2) absence of orthostatic hypotension, arrhythmia, vascular abnormalities, or other causes of abnormal ortho-


    • [PDF File]The protective effect of Thai Herbal Sahatsatara formula ...

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      observed at an advanced age. Chronic cerebral hypoperfusion is one of many causes, resulting in cognitive impairments in elderly population. Many factors cause chronic cerebral hypoperfusion such as hypertension and diabetes. In non-invasive scanning study, the regional cerebral blood flow (CBF) in the hippocampus, an area susceptible to ...


    • [PDF File]Syncope: Evaluation and Differential Diagnosis

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      Syncope is an abrupt and transient loss of consciousness caused by cerebral hypoperfusion. It accounts for 1% to 1.5% of emergency department visits, resulting in high hospital admission rates and ...


    • [PDF File]Cerebrovascular Disease (Dr

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      infarctions, and is more commonly due to other causes such as cerebral hypoperfusion, vasovagal syncope, or toximetabolic disorders. Some focal neurological deficits occur transiently from migraine or after seizures, and may mimic cerebrovascular disease (rarely migraine-related ischemic infarctions do occur). Cerebrovascular disease follows


    • [PDF File]TIME-RELATED SEX DIFFRENCES IN CEREBRAL HYPOPERFUSION ...

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      In the current study, we examined whether cerebral hypoperfusion causes changes in hippocampal protein ex-pression of apoptotic markers in the synaptosomal fraction and neurodegeneration in a time-dependent and sex-specific manner. Adult male and female Wistar rats were divided into two main groups, controls that underwent sham operation,


    • [PDF File]TRPM2ChannelAggravatesCNSInflammationand ...

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      Chronic cerebral hypoperfusion, resulting in an inadequate sup-plyofbloodtothebrain,iselicitedbyaging(Aanerudetal.,2012) and a variety of risk factors such as atherosclerosis, hypertension, and obesity (Daulatzai, 2017). It has been previously suggested that chronic cerebral hypoperfusion is highly related to dementia


    • [PDF File]An Experimental Model of Vasovagal Syncope Induces ...

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      explored: cerebral perfusion. Despite VVS pathophysiology including the reductions in blood pressure and heart rate, VVS culminates in loss of conscious, typically leading to a fall [11]. Although the consensus is that cerebral hypoperfusion ultimately causes the fainting episode, currently there is limited


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