Cholesterol absorption and metabolism
[PDF File]ZETIA - Food and Drug Administration
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Ezetimibe reduces blood cholesterol by inhibiting the absorption of cholesterol by the small intestine. In a 2-week clinical study in 18 hypercholesterolemic patients, ZETIA inhibited intestinal cholesterol absorption by 54%, compared with placebo. ZETIA had no clinically meaningful effect on the plasma
[PDF File]Cell Metabolism Article
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Cell Metabolism Article The Cholesterol Absorption Inhibitor Ezetimibe Acts by Blocking the Sterol-Induced Internalization of NPC1L1 Liang Ge,1,3 Jing Wang,1,3 Wei Qi,2,3 Hong-Hua Miao,1 Jian Cao,1 Yu-Xiu Qu,1 Bo-Liang Li,1 and Bao-Liang Song1,* 1State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology 2Key Laboratory of Nutrition and Metabolism, Institute for ...
[PDF File]A review on dietary phytosterols: Their occurrence ...
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cholesterol also serves as a precursor for the biosynthesis of steroid hormones, bile acids and vitamin D [2]. Although cholesterol is the predominant sterol in animals including humans, a variety of sterols are found in plants, ... ABSORPTION AND METABOLISM Though various diets contain similar amounts of phytosterols and cholesterol, serum ...
for Cholesterol Absorption and Synthesis in Different ...
In general, markers for cholesterol absorption and synthesis displayed reciprocal patterns, showing that cholesterol metabolism is tightly regulated by the interplay of intestinal absorption and endogenous synthesis. Distinctive patterns for cholesterol absorption or cholesterol synthesis could be identified, suggesting that metabolic ...
[PDF File]Cholesterol and Glucose Metabolism and Recurrent ...
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also connected to cholesterol metabolism (9–13). Specifi-cally, a metabolic syndrome-type state is characterized by high synthesis and decreased absorption of cholesterol (9,10,13). In these studies we have used the serum measure-ment of some noncholesterol sterols to reflect cholesterol synthesis and absorption (14–16). Of these sterols ...
Regulation of Cholesterol Metabolism in the Intestine
cholesterol synthetic rates decrease and esterifica- tion rates increase. The mechanisms by which di- etary fats regulate intestinal cholesterol metabolism are complex. Dietary fats alter membrane fatty acid composition. Simultaneously, they also promote li- poprotein secretion and alter cholesterol absorption.
[PDF File]Cholesterol metabolism
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In man, increased absorption of cholesterol is followed byincreased excretion ofcholesterol from the exchangeable pool. In some species, not in-cluding man, increased absorption of dietary cholesterol leads to increased conversion ofcholes-terol into bile acids. Increased conversion ofcholes-terol into bile acids is also brought about by inter-
[PDF File]Dietary cholesterol absorption
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processes of cholesterol absorption and excretion Dietary sterol absorption and the sites of defects in sitosterolaemia in the general population. Shailesh Patel is an associate professor of medicine and a clinical scientist with an interest in genetic disorders of cholesterol metabolism.
[PDF File]Cholesterol Absorption, Synthesis, and LDL Metabolism in …
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RESULTS — Cholesterol absorption was significantl iny NIDD loweMr subjects than in the control subjects, as detected by low serum plant sterol levels and absorption percentage (23 vs. 29%, P < 0 ...
Human cholesterol metabolism and therapeutic molecules
Human cholesterol metabolism and therapeutic molecules V. Charlton-Menys and P. N. Durrington ... Ezetimibe, which was developed to block cholesterol absorption from the intestine, led to the discovery of the Nieman-Pick C1-Like 1 sterol transporter channel. The statins, which have proved enormously successful in preventing cardiovascular ...
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