Cholesterol biosynthetic pathway
[DOC File]Chapter 3: Energy, Catalysis, and Biosynthesis
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One of the important functions of the pathway is the reduced cosubstrate NADPH, which is used for metabolic functions such as fatty acid biosynthesis. The cells of tissues that are active in the synthesis of fatty acids, for example, the mammary gland, adipose tissue, adrenal cortex, and the liver, need NADPH.
[DOC File]Online Appendix 4: Table shows the gene ontology (GO ...
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38. Zhang H, Abraham N, Khan LA et al. RNAi-based biosynthetic pathway screens to identify in vivo functions of non-nucleic acid–based metabolites such as lipids. Nature protocols. 2015; 10: 681-700. 39. Chong J, Soufan O, Li C et al. MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis. 2018; 46: W486-94. 40.
[DOC File]Introduction to Cholesterol Metabolism
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These results suggest that the reduction of isoprenoid intermediates in the cholesterol biosynthetic pathway is related to insulin resistance. Isoprene residues are among the important intermediate molecules of the mevalonate synthesis pathway and are also required for the synthesis of CoQ10 [19].
[DOC File]International Journal of Biological Sciences
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(d)biosynthetic. 3-2When there is an excess of nutrients available in the human body, insulin is released to stimulate the synthesis of glycogen from glucose. This is a specific example of a(n) _____ process, a general process in which larger molecules are made from smaller molecules. (a)metabolic (b)catabolic (c)anabolic (d)biosynthetic
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cholesterol content of HDL (fewer cholesterol esters in HDL core)—smaller HDL-3 particles have lower lipid to protein ration and is atherogenic. ... (rate limiting step in cholesterol biosynthetic pathway; autosomal recessive. Familial hypercholesterolemia: same symptoms as ligand-defective apoB-100 (increased serum .
Cholesterol Biosynthesis Regulation | Sigma-Aldrich
Pathway for the movement of acetyl-CoA units from within the mitochondrion to the cytoplasm for use in lipid and cholesterol biosynthesis. Note that the cytoplasmic malic enzyme catalyzed reaction generates NADPH which can be used for reductive biosynthetic reactions such as those of fatty acid and cholesterol synthesis.
[DOCX File]Weebly
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Figure S3, Related to Figure 3. Ingenuity pathway analysis (IPA) of canonical pathways in response to CYB5R3 overexpression in the livers of SD-fed mice . Figure S4, Related to Figure 3. IPA’s canonical pathway within the category of “Xenobiotic P450 pathway” in CYB5R3-Tg mice fed SD. Figure S5, Related to Figure 4.
[DOC File]Diseases/Disorders
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Cholesterol biosynthetic process ... GO:0006694 Steroid biosynthetic process 3 17.65% 1.29E-03 GO:0016125 Sterol metabolic process 3 17.65% 1.39E-03 KEGG_PATHWAY Biosynthesis of steroids 2 …
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