Cholesterol metabolism pdf
[PDF File]•Function •Biosynthesis •Transport in theorganism ...
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Cholesterol metabolism •Function •Biosynthesis •Transport in theorganism •Hypercholesterolemia. Cholesterol -componentofallcell membranes-precursor of bileacids steroid hormones vitamin D Sources: dietarycholesterol (~ 25% ofa dailyturnover) -0,3g/day synthesisin tissues(~ 75 %) - 1 g/day
[PDF File]METABOLISME DU CHOLESTEROL
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Stockage du cholesterol •Les 2/3 du cholesterol sont sous forme esterifiée •Cette esterification se déroule au niveau du foie pa l’ACAT •La LCAT (lécithine cholesterol acyl transférase) est une enzyme plasmatique spécifique synthétisée au niveau du foie qui produit des esters de cholesterol a …
[PDF File]Cholesterol Metabolism - Western Oregon University
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Hypercholesterolemias • Familial Hypercholesterolemias: Genetic defect • Five classes of mutations • no receptor synthesized • receptor not transported to cell surface • receptor does not bind LDL • receptor may not cluster in pits • receptor may not release LDL in the cell • autosomal dominant disorder • Heterozygote plasma levels of LDL: 320-500 mg/dL, increased
[PDF File]Cholesterol - The Heart Foundation
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Cholesterol is a white, waxy, fatty substance. It is made in the liver and released into the bloodstream. You can also get cholesterol from the food you eat. It is important to get your cholesterol checked and learn how to manage your cholesterol. The different types of cholesterol HDL High-density lipoprotein (HDL) cholesterol is sometimes
[PDF File]Introduction to Lipid Metabolism Roles of Lipids
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High levels of LDL cholesterol are associated with elevated risk of heart disease. LDL cholesterol is the “bad cholesterol” of the popular literature. HDL The intestine and the liver release HDL. HDL particles contain Apo-C and Apo-E, which can be transferred to VLDL and …
[PDF File]Cholesterol metabolism
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Clofibrate has several effects on cholesterol metabolism, including increased excretion ofcholes-terol from the exchangeable pool, decreased se-cretion of lipoprotein by the liver and diminished hepatic synthesis ofcholesterol, but it is not known which, if any, of these effects is mainly responsible
[PDF File]Cholesterol balance and metabolism in mice with loss of ...
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Cholesterol balance and metabolism in mice with loss of function of Niemann-Pick C protein CHONGLUN XIE, 1STEPHEN D. TURLEY, PETER G. PENTCHEV,2 AND JOHN M. DIETSCHY1 1Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235-8887; and 2Developmental and Metabolic Neurology Branch, National Institute
[PDF File]Cholesterol, steroids, and related molecules
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metabolism, and sexual differentiation). Overview of cholesterol metabolism. Cholesterol can be obtained from the diet, or can be synthesized, primarily in the liver and adrenal gland, from acetyl-CoA. Its main fates are export to peripheral tissues for membrane biogenesis and conversion to bile salts in the liver.
[PDF File]Chapter 16 - Lipid Metabolism
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Chapter 16 - Lipid Metabolism • Triacylglycerols (TGs) and glycogen are the two major forms of stored energy in vertebrates • Glycogen can supply ATP for muscle contraction for less than an hour • Sustained work is fueled by metabolism of TGs which are very efficient energy stores because: (1) They are stored in an anhydrous form
[PDF File]Cholesterol biosynthesis - IJS
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cholesterol levels are also modulated by a cycle of cholesterol esterification by acyl- CoA : cholesterol acyltransferase (ACAT) and hydrolysis of the cholesteryl esters, and by cholesterol metabolism to bile acids and oxysterols. 2. The cholesterol biosynthetic pathway
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