Cholesterol pathway

• HDL and Reverse Cholesterol Transport

  leading to the identification of the reverse cholesterol trans-port (RCT) pathway.2 RCT is defined as the process by which cholesterol moves out of cells in peripheral tissues (including foam cells in atherosclerotic plaques), enters the circulation, and is excreted in …

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• Molecular Pathways Underlying Cholesterol Homeostasis

  Cholesterol biosynthesis and uptake are tightly regulated by a mechanism of negative feedback that senses cholesterol and oxysterols. The transcription factor sterol regulatory element-binding protein-2 (SREBP-2; Srebf2) is the key regulator of genes involved in cholesterol synthesis such as

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• [PDF File]The Role of Cholesterol in Cancer

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  the cholesterol synthesis pathway was correlated with decreased patient survival while in lower grade glioma it was associated with enhanced survival(Fig.1A).Thus,basedonthe TCGA database, there appears to be a correlative link between cholesterol synthesis pathway and prognostic outcome that could be cancer-type specific.

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• [PDF File]Cellular control of cholesterol - Yale University

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  Cellular cholesterol levels regulate expression of enzymes in cholesterol synthesis pathway. Increase cellular cholesterol Low cellular cholesterol When cells are faced with low cholesterol levels, they respond by increasing the gene expression of proteins that stimulate biosynthesis of cholesterol, such as

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• Limiting Cholesterol Biosynthetic Flux Spontaneously ...

  of lipid metabolites (e.g., cholesterol) for pathogens as has been proposed, or if there are alternative reasons for the selec-tive reprogramming of flux through the cholesterol biosynthetic pathway. Herein, we examine this question and delineate a lipid meta-bolic …

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• [PDF File]Cholesterol, steroids, and related molecules

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  CHOLESTEROL, STEROIDS, AND RELATED MOLECULES Peter D'Eustachio – December 4 - 5, 2006 Objectives. Understand the overall pathways of sterol uptake, synthesis, transport, and utilization and their regulation; be able to explain why a deficiency of LDL receptors leads to elevated blood cholesterol. Understand the rationale for pharmacological ...

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• [PDF File]Cholesterol: Biosynthesis, Functional Diversity ...

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  Cholesterol: Biosynthesis, Functional Diversity, Homeostasis and Regulation by Natural Products 423 oxygenase and sequalene 2, 3 epoxidase enzymes. Sequalene mono oxygenase is the second committed step in cholesterol biosynthesis and lead to the formation squalene 2, 3 epoxide.

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• [PDF File]Cholesterol metabolism

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  Cholesterol balance studies suggestthattheextentto which cholesterol synthesis is suppressed by dietary cholesterol varies from one individual to another and,possibly,fromoneracetoanother.Somehuman subjects show no evidence of suppression of endo-genoussynthesiswhencholesterol intakeis increased, whereas others show quite marked suppression. It

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• Increased Cholesterol Biosynthesis Is a Key Characteristic ...

  cholesterol synthesis. The clinical relevance of increased cholesterol biosynthesis was verified in a large breast cancer cohort showing correlation with shorterrelapse-freesurvival.RNAiandchemicalinhi-bition of the cholesterol biosynthesis pathway reduced mammosphere formation, which could be rescued by a downstream metabolite. Our findings

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• [PDF File]Cholesterol biosynthesis - IJS

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  cholesterol levels are also modulated by a cycle of cholesterol esterification by acyl- CoA : cholesterol acyltransferase (ACAT) and hydrolysis of the cholesteryl esters, and by cholesterol metabolism to bile acids and oxysterols. 2. The cholesterol biosynthetic pathway

  cholesterol metabolism pdf

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