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[PDF File]The Role of Cholesterol in the Pathogenesis of NASH
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cholesterol homeostasis, the net ﬂow of sterol through the liver from the intestine, peripheral organs, and local synthesis (143 mg/day/kg) is large, such that 108% of the hepatic cholesterol pool turns over every day [26]. The main pathways by which hepatocytes acquire cholesterol, shown
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Molecular Pathways Underlying Cholesterol Homeostasis
nutrients Review Molecular Pathways Underlying Cholesterol Homeostasis Milessa Silva Afonso 1,*, Roberta Marcondes Machado 2, Maria Silvia Lavrador 2, Eder Carlos Rocha Quintao 2, Kathryn J. Moore 1,3 and Ana Maria Lottenberg 2,4 1 Marc and Ruti Bell Vascular Biology and Disease Program, Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New ...
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[PDF File]Cholesterol: Biosynthesis, Functional Diversity ...
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Cholesterol: Biosynthesis, Functional Diversity, Homeostasis and Regulation by Natural Products 423 oxygenase and sequalene 2, 3 epoxidase enzymes. Sequalene mono oxygenase is the second committed step in cholesterol biosynthesis and lead to the formation squalene 2, 3 epoxide.
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Human cholesterol metabolism and therapeutic molecules
eph˙450 EPH-xml.cls December 15, 2007 19:15 Exp Physiol 93.1 pp 27–42 27 Experimental Physiology – Review Article Human cholesterol metabolism and therapeutic …
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[PDF File]Cholesterol metabolism - Journal of Clinical Pathology
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cholesterol in the body. The relative importance of these mechanisms differs widely in different species. When laboratory animals are fed diets rich in cholesterol, hepatic synthesis of cholesterol is almost completely inhibited, owing to repression of thesynthesis ofHMG-CoAreductase. This provides the animal with a regulatory system by which
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Critical Review The Role of Signalling in Cellular ...
Considering that cholesterol is an essential requirement for growing and proliferating cells, this molecule has been impli-cated in many cancer settings, especially prostate cancer (4,5). An overview of key signalling pathways involved in cholesterol metabolism. Numbers in parentheses indicate section numbers in this review.
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[PDF File]β-glucans and cholesterol (Review) - Beta Glucan Data
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consequently reduce cholesterol levels. Therefore, they may be developed as a suitable therapeutic option to treat patients with dyslipidemia, as they are natural molecules that do not induce any significant side effects. The current review discusses the evidence supporting the effects of β-glucans on cholesterol levels. Contents 1 ...
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[PDF File]Cholesterol biosynthesis - IJS
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Fig. 1 is an overview of the metabolic and transport pathways that control cholesterol levels in mammalian cells (reviewed in Liscum and Munn [1]). Cholesterol is synthe- sized from acetyl-CoA via the isoprenoid pathway, and at least four enzymes in the biosynthetic pathway are regulated by cellular cholesterol levels. ...
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Cholesterol Metabolism: A Potential Therapeutic Target in ...
amino acid metabolism in GBM, in this review we will discuss the role of cholesterol metabolism in inﬂuencing tumor cell growth and proliferation and as a potential therapeutic target. 3. Feedback Pathways in Cholesterol Biosynthesis Cholesterol is critical for cell growth and function. It is important not only as a component of
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Cholesterol efflux pathways and other potential mechanisms ...
steps of reverse cholesterol transport or other aspects of HDL biology, development of transgenic mouse models and the beginning of human clinical trials tar-geting HDL. This review will summarize recent advances in the basic science of HDL, macrophage cholesterol efﬂux pathways and reverse cholesterol transport. We will describe how the ...
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Cholesterol pathways review