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[DOCX File]WordPress.com
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Which of the enzymes in ketone body synthesis might be deficient? If cholesterol synthesis were normal, how would this be a clue as to which enzyme might be deficient? 1989-PM-A06 Explain the significance of HDL and LDL in cholesterol transport and metabolism. 1988-SS-A11 (a) What is the rate limiting step in the formation of (i) acetoacetic acid and (ii) cholesterol? (b) What is the ...
regulation of cholesterol synthesis

[DOC File]Dyslipidemia
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The other half of IDL are modified to become LDL particles (major cholesterol-carrying particle in serum). LDL in turn either go to the liver or to the extra hepatic tissues & if excess oxidized , engulfed by macrophages then embedded on blood wall. *While VLDL and LDL are considered the ‘bad’ lipoproteins, HDL is often considered to be the ‘good’ antiatherogenic lipoprotein. Pathology ...
cholesterol synthesis pathway

[DOC File]SPS
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endogenous (liver and intestine) and exogenous (20-40% of serum cholesterol – diet) synthesis. biosynthesis (modulated by HMG CoA reductase) ( between midnight and 3 a.m. target TC < 5.2 mmol/L. Lipoproteins. cholesterol and triglycerides are water-insoluble; transported through blood in the form of lipoproteins. 5 classes: chylomicron, VLDL, IDL, LDL, HDL . Low-density lipoprotein (LDL ...
synthesis of cholesterol

[DOCX File]C O N T E N T
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High blood cholesterol level is a well-known risk factor for CVD and several drugs are available to reduce cholesterol synthesis. Similarly, phytosterols have been developed to reduce cholesterol absorption during food digestion. However, a potentially safer and effective method involves the use of protein materials that are resistant to gastrointestinal tract (GIT) digestion. These resistant ...
liver cholesterol synthesis

UKMi Q&A xx
What is the mechanism of action of cholesterol synthesis lowering drugs? 8. Can cholesterol be degraded to CO. 2 and H 2. O in the body?9. How can excess cholesterol be removed from the body? 10. What are the characteristic reactions of the bile acid synthesis? Which of them is the rate-limiting step? What is the meaning of bile acid coupling reactions? What is the role of intestinal bacteria ...
endogenous cholesterol synthesis

[DOC File]STATIN-ASSOCIATED MEMORY LOSS – One Mechanism Identified
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Cholesterol 7-hydroxylase is the rate-limiting enzyme in the synthesis of bile acid form cholesterol in the classical pathway. This enzyme is the subject of feedback control. It is downregulated by sterol regulatory element-binding protein (SREBP) when the level of plasma cholesterol is low. On the opposite, it is upregulated by the nuclear receptor LXR (liver X receptor) when cholesterol ...
cholesterol biosynthesis pathway

[DOCX File]Protein isolation - Manitoba Pulse & Soybean Growers
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Statins competitively inhibit HMG-CoA reductase and decrease synthesis of melvalonate, which is involved in the cholesterol synthesis pathway. (9) The mechanism of statin-induced myopathy is unknown but one possible mechanism suggested is due to mitochondrial dysfunction caused by reduced intramuscular coenzyme Q10.(9) Coenzyme Q10 (CoQ10), also known as ubiquinone, is a fat-soluble ...
cholesterol pathway

Cholesterol: Synthesis, Metabolism, Regulation
Regulating Cholesterol Synthesis. Normal healthy adults synthesize cholesterol at a rate of approximately 1g/day and consume approximately 0.3g/day. A relatively constant level of cholesterol in the body (150 - 200 mg/dL) is maintained primarily by controlling the level of de novo synthesis. The level of cholesterol synthesis is regulated in part by the dietary intake of cholesterol ...
woodward synthesis of cholesterol

[DOCX File]No 21
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Statins competitively inhibit the HMG-CoA reductase enzyme and decrease synthesis of mevalonate, which is involved in the cholesterol synthesis pathway (9). The mechanism of statin-induced myopathy is unknown but one possible mechanism suggested is due to mitochondrial dysfunction caused by reduced intramuscular coenzyme Q10 (9). Coenzyme Q10 (CoQ10), also known as ubiquinone, is a …
regulation of cholesterol synthesis

[DOC File]Biosynthesis of Cholesterol
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PURPOSE: Identify the mechanism by which HMG CoA reductase inhibitors, the cholesterol-lowering class of statin drugs, induce memory loss. BACKGROUND: Cognitive adverse drug reactions (ADRs), including, amnesia, transient global amnesia, aphasia and impairment of short term memory, have been documented in association with statins. The damage is ...
cholesterol synthesis pathway

Cholesterol synthesis mechanism