Combination diuretic therapy
[PDF File] Using diuretic therapy in the critically ill patient - Springer
http://5y1.org/file/20529/using-diuretic-therapy-in-the-critically-ill-patient-springer.pdf
What are the indications for diuretics in critically ill patients? Diuretics are first-line therapy to remove excess fluid, as monotherapy or in combination using loop diuretics, carbonic anhydrase inhibitors, thiazides, and thiazide-like drug classes.
[PDF File] Combination of Loop Diuretics With Thiazide-Type Diuretics in …
http://5y1.org/file/20529/combination-of-loop-diuretics-with-thiazide-type-diuretics-in.pdf
Combination diuretic therapy using any of several thiazide-type diuretics can more than double daily urine sodium excretion to induce weight loss and edema resolution, at the risk of inducing severe hypokalemia in addition to hyponatremia, hypotension, and …
[PDF File] Diuretic use in renal disease - Nature
http://5y1.org/file/20529/diuretic-use-in-renal-disease-nature.pdf
Multiple diuretic classes, including thiazide‐type diuretics, loop diuretics and K+‐sparing diuretics, are used to treat patients with these diseases, either individually or as combination ...
[PDF File] Efficacy and Safety of Calcium Channel Blocker/Diuretics …
http://5y1.org/file/20529/efficacy-and-safety-of-calcium-channel-blocker-diuretics.pdf
The objective of the current analysis was to evaluate the available studies in which CCBs and thiazide (-like) diuretics as a combination therapy were compared with any other monotherapy, combination therapy, or pla-cebo for the management of hypertension and reported prespecified endpoints (ie, all-cause mortality, cardio-vascular mortality ...
[PDF File] Diuretic Treatment in Patients with Heart Failure: Current
http://5y1.org/file/20529/diuretic-treatment-in-patients-with-heart-failure-current.pdf
In these two articles (part I: loop diuretics and part II: combination therapy), we will review the history of diuretic treatment and the current trial evidence for dierent diuretic strategies and explore potential future directions of research.
[PDF File] Combination Diuretic Therapy With Thiazides: A Systematic …
http://5y1.org/file/20529/combination-diuretic-therapy-with-thiazides-a-systematic.pdf
However, despite the widespread use of combination diuretic therapy, there is little published research to guide clinicians in choosing the right timing and type of diuretics. This systematic review evaluates the effectiveness and safety of combination diuretic therapy with thiazide diuretics in refractory HF.
[PDF File] Combination Diuretic Therapy With Thiazides: A Systematic …
http://5y1.org/file/20529/combination-diuretic-therapy-with-thiazides-a-systematic.pdf
However, despite the widespread use of combination diuretic therapy, there is little published research to guide clinicians in choosing the right timing and type of diuretics. This systematic review evaluates the effectiveness and safety of combination diuretic therapy with thiazide diuretics in refractory HF.
[PDF File] Rationale and Design of the Safety and Efficacy of the …
http://5y1.org/file/20529/rationale-and-design-of-the-safety-and-efficacy-of-the.pdf
ABSTRACT Background: Fluid overload refractory to loop diuretic therapy can complicate acute or chronic heart failure (HF) management. The Safety and Efficacy of the Combination of Loop with Thiazide-type Diuretics in Patients with Decompensated Heart Failure (CLOROTIC) trial (Clinicaltrials.gov identifier NCT01647932) will test the hypothesis that …
[PDF File] Combination Diuretic Therapy in Severe Congestive Heart …
http://5y1.org/file/20529/combination-diuretic-therapy-in-severe-congestive-heart.pdf
Recent studies give insight in to some of the pathophysiological mechanisms in-volved in diuretic resistance. In this article, we fo-cus on the mechanisms that explain the synergism of combinations of diuretic drugs in severe heart failure, indications for their use and adverse ef-fects.
[PDF File] CHF-MA2003-Comp - Wiley Online Library
http://5y1.org/file/20529/chf-ma2003-comp-wiley-online-library.pdf
Metolazone is a thiazide-type diuretic that is character-ized by slow and sometimes erratic absorption when ad-ministered as the Zaroxylyn product. This absorptive profile together with the large volume of distribution and high degree of renal clearance for metolazone provide the pharmacologic basis for a favorable diuretic combination effect.
[PDF File] How do we maximize diuresis in acute decompensated heart …
http://5y1.org/file/20529/how-do-we-maximize-diuresis-in-acute-decompensated-heart.pdf
A: in patients with acute decompensated heart failure (ADHF), the initial diuretic regimen should maximize intravenous loop diuretics based on urine output or spot urine sodium. Combina-tion therapy can be used if diuretic resistance occurs. ADHF accounts for more than 1 million hospi-talizations per year in the United States, and inad-equate ...
[PDF File] Safety and clinical outcome in combination therapy for high …
http://5y1.org/file/20529/safety-and-clinical-outcome-in-combination-therapy-for-high.pdf
The Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension (ACCOM-PLISH) trial involves xed-dose drug combi-fi nations in a double-blind clinical ...
[PDF File] Sequential Combination Diuretic-Therapy for Massive Fluid …
http://5y1.org/file/20529/sequential-combination-diuretic-therapy-for-massive-fluid.pdf
In the present study, we evaluated the efficacy of sequential combination diuretic-therapy \(SCDT\) in management of massive fluid overload in Furosemide-\ refractory renal patients.
[PDF File] Effect of levosimendan combined with recombinant human …
http://5y1.org/file/20529/effect-of-levosimendan-combined-with-recombinant-human.pdf
a monotherapy, it may be necessary to combine it with other diuretic agents such as recombinant human brain natriuretic peptide (rhBNc P). The aim of this study was to investigate efficacy of levosimendan when combined with rhBNP in patients with diuretic resistance and low ejection fraction (EF) rate.
[PDF File] Managing Hypertension Using Combination Therapy
http://5y1.org/file/20529/managing-hypertension-using-combination-therapy.pdf
Four main classes of medications are used in combination therapy for the treatment of hypertension: thiazide diuretics, calcium channel blockers, angiotensin-converting enzyme inhibitors (ACEIs ...
[PDF File] Decongestion in Acute Heart Failure—Time to Rethink and …
http://5y1.org/file/20529/decongestion-in-acute-heart-failure—time-to-rethink-and.pdf
Furthermore, urine characteristics change dramatically between the first and the following days in AHF patients undergoing IV loop diuretic therapy (progressive decrease in urinary sodium and chloride), even if urine output remains the same relative to the diuretic dose (= diuretic eficiency) [20].
[PDF File] Diuretic response in acute heart failure pathophysiology, …
http://5y1.org/file/20529/diuretic-response-in-acute-heart-failure-pathophysiology.pdf
Several strategies have been proposed to overcome diuretic resistance, including combination therapy and ultrafiltration, but prospective studies in patients who are truly unresponsive to ...
[PDF File] Combination Therapy: Advantages and Disadvantages of First …
http://5y1.org/file/20529/combination-therapy-advantages-and-disadvantages-of-first.pdf
Approval of a low-dose combination drug for initial therapy re-quires that each component contributes to. the blood pressure lowering effect, plus ev-idence that any dose dependent adverse ef-fects are offset by the benefits.11 Many of the fixed dose combinations fea-ture very low doses of a diuretic. Specific-.
[PDF File] link.springer.com
http://5y1.org/file/20529/link-springer-com.pdf
The purpose of this review is to evaluate the existing evidence concerning the use of metolazone in conges-tive heart failure. Furthermore, we report the to-date largest material adressing the use of the combination of a loop diuretic and metolazone in outpatients with refractory systolic HF.
[PDF File] Home | AAFP
http://5y1.org/file/20529/home-aafp.pdf
Combination therapy is treatment with two or more agents adminis-tered separately or in a fixed-dose combination pill and is required by most patients with hypertension to reach target blood ...
[PDF File] Hypertension Management: Rationale for Triple Therapy …
http://5y1.org/file/20529/hypertension-management-rationale-for-triple-therapy.pdf
This review discusses the triple-therapy combination of an angiotensin receptor blocker (ARB) or direct renin antagonist (DRI) with a calcium channel blocker (CCB) and a diuretic, with a focus on mechanisms of action. Multiple physiologic pathways contribute to …
[PDF File] Outcomes Associated With a Strategy of Adjuvant Metolazone …
http://5y1.org/file/20529/outcomes-associated-with-a-strategy-of-adjuvant-metolazone.pdf
Background-—In acute decompensated heart failure, guidelines recommend increasing loop diuretic dose or adding a thiazide diuretic when diuresis is inadequate. We set out to determine the adverse events associated with a diuretic strategy relying on metolazone or high-dose loop diuretics.
[PDF File] Combination Diuretic Therapy With Thiazides: A Systematic …
http://5y1.org/file/20529/combination-diuretic-therapy-with-thiazides-a-systematic.pdf
diuretics [17,25]. However, despite the widespread use of combination diuretic therapy, there is little published research to guide clinicians in choosing the right timing and type of diuretics. This systematic review evaluates the effectiveness and safety of combination diuretic therapy with thiazide diuretics in refractory HF.
[PDF File] Combination therapy of hypertension in the elderly: a …
http://5y1.org/file/20529/combination-therapy-of-hypertension-in-the-elderly-a.pdf
Combination of OLMesartan and a calcium channel blocker or a diuretic in Japanese elderly hypertensive patients (COLM) trial demonstrated that olmesartan combinations with a CCB or diuretic have ...
[PDF File] Combination antihypertensive therapy in clinical practice. The …
http://5y1.org/file/20529/combination-antihypertensive-therapy-in-clinical-practice-the.pdf
The aim of the study was to analyze the clinical use of different types of combination therapy in a large sample of consecutive patients with uncontrolled hypertension referred to Hypertension Centre.
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