Cyclic amp phosphodiesterase
[DOCX File]SEDA-19
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Phosphodiesterases are enzymes that cause the breakdown of cyclic AMP, as second messenger in receptor-mediated effects (see Figure 2). There are several different isoforms of phosphodiesterase in different tissues. The xanthines (for example theophylline) inhibit phosphodiesterase in the lung, causing bronchodilatation.
[DOCX File]Australian Public Assessment Report for Apremilast
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APR belongs to the class of small molecule phosphodiesterase 4 (PDE4) inhibitors which act intracellularly to prevent the degradation of cyclic adenosine monophosphate (cAMP) to inactive AMP, thereby increasing the intracellular concentration of cAMP.
[DOC File]Biology 4410 - Kennesaw State University
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Cyclic AMP phosphodiesterase acts to break down cAMP, reducing its level in the cells. Researchers developed a learning test in which flies were presented two metallic grids, one of which was electrified. If the electrified grid was painted with a strong-smelling chemical, normal flies learned quickly to avoid the grid even when it was no ...
[DOC File]Sample study questions on cell signaling
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Cyclic AMP phosphodiesterase acts to break down cAMP, reducing its level in the cells. Researchers developed a learning test in which flies were presented two metallic grids, one of which was electrified. If the electrified grid was painted with a strong-smelling chemical, normal flies learned quickly to avoid the grid even when it was no ...
Chapter 3
b. the cAMP (cyclic AMP) second messenger mechanism. the effector protein is the enzyme adenylyl cyclase, which converts intracellular ATP into cyclic AMP by removing 2 terminal phosphates ... cAMP is inactivated by phosphodiesterase (PDE) cAMP is used as a 2nd messenger in many different cell types – how can it generate different responses ...
[DOCX File]San Diego Miramar College
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phosphodiesterase. that breaks down cyclic AMP. As a result, the amount of cyclic AMP in heart cells increases, duplicating the action of . epinephrine. Caffeine's usefulness as a CNS stimulant is limited since high doses can promote the formation of . ectopic focus . resulting in arrhythmias.
[DOC File]Steven A - professorfink
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____40. Organophosphate insecticides like malathion: (a) block the effect of ACh at Adrenergic receptor sites (b) activate ACh receptor sites (c) activate cyclic-AMP in cells (d) inhibit phosphodiesterase cyclic-AMP (e) inhibit AChase (ab) block Ach Recepor Sites ____41.
[DOC File]AP Biology Chapter 15 Worksheet - Sault Schools
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Explain what happens with an increase in concentration of cyclic AMP. Explain the function of adenylyl cyclase. Explain the function of phosphodiesterase. Explain how a hormone can trigger the formation of cAMP. Explain how microbes can affect G-protein signaling pathways.
[DOC File]Introduction - Digital CSIC
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72. Sasaki T, Kotera J, Omori K. Transcriptional activation of phosphodiesterase 7B1 by dopamine D1 receptor stimulation through the cyclic AMP/cyclic AMP-dependent protein kinase/cyclic AMP-response element binding protein pathway in primary striatal neurons. J Neurochem 2004;89:474-83. 73.
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