Desmopressin for di
[DOCX File]Australian Public Assessment Report for Desmopressin
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Desmopressin is indicated for nocturnal polyuria secondary to diabetes insipidus. Urologists Expert 2 It is important to rule out severe prostatic obstruction / other problems which may interfere with renal concentrating function.
[DOC File]WATER DEPRIVATION TEST AND DESMOPRESSIN TEST IN …
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Diabetes insipidus (DI) involves deficient production or lack of effective action of antidiuretic hormone (ADH or arginine vasopressin). ADH stimulates the kidney to conserve fluid. Deficient production of ADH or lack of effective action of ADH causes a high urine output, thirst, dehydration, and low blood pressure in advanced cases.
[DOC File]fiziopatologie.usmf.md
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The preferred drug for treating chronic DI is desmopressin acetate (DDAVP). It usually is given orally, but is also available in parenteral and nasal forms. The oral antidiabetic agent chlorpropamide may be used to stimulate ADH release in partial neurogenic DI. It usually is reserved for special cases because of its ability to cause hypoglycemia.
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For DI with significant hypernatremia (sodium >145-150 mmol/L) without hypotension, treatment with desmopressin should be initiated. After an initial IV dose of 1 to 4 g, additional dosing should be titrated to urine output, urine osmolality, and serum sodium. Typically, an additional 1 or 2 g every 6 hours will be required, although higher ...
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