Direct vs indirect hyperbilirubinemia
[DOC File]Gastroenterology - Stanford University
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Isolated hyperbilirubinemia. Indirect hyperbilirubinemia, >85% of total bilirubin is unconjugated. Total bilirubin usually never >6 mg/dL in hemolysis. Check reticulocyte count and hemolysis labs . Direct hyperbilibinemia, >50% of total bilirubin is conjugated. Causes of indirect hyperbilirubinemia. Hemolysis. Ineffective erythropoiesis
[DOCX File]Indiana University Bloomington
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Clinical: enzyme synthesis vs enzyme stability Paroxysmal Nocturnal Hemoglobinuria Somatic mutation of pluripotential stem cell decreased glycosyl phosphatidyl inositol (GPI: a phospolipid anchoring non-transmembrane proteins); decreased GPI decreased GPI-linked proteins regulating complement increased sensitivity of RBCs to complement
[DOCX File]WordPress.com
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hyperbilirubinemia / jaundice→light-colored stools → cirrhosis → portal . hypertension→encephalopathy. Biliary. cirrhosis (primary) Affect women & those > 30 years old. Life expectancy is 5-10 years after onset of symptoms. Disease specific antibodies can be detected—
CPQCC
Steffensrud, S. (2004). “Hyperbilirubinemia in term and near term infants: Kernicterus on the rise? Newborn and Infant Nursing Reviews, 4(4) 191-200. Subcommittee on Hyperbilirubinemia, American Academy of Pediatrics. Management of Hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics 2004,114:297-316.
[DOC File]Josh Corwin
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Unconjugated indirect insoluble. Bound to albumin- liver . Indirect bilirubin- glucuronosyltransferase- conjugated bilirubin. Conjugated, direct, soluble. Bile channels- ATP pump. Excreted via feces and urine. Overproduction of bilirubin. Impaired uptake or . Prehepatic increase heme production. Spherocytosis sickle cell anemia G6PD deficiency
[DOC File]ระบาดวิทยาของภาวะติดเชื้อราชนิดรุนแรงในผู้ป่วยเด็ก ...
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Jaundice in term newborns is a frequent diagnosis in the first postnatal week. Hyperbilirubinemia, when excessive, can lead to potentially irreversible bilirubin-induced neurotoxicity. Predischarge risk assessment (at 24-72 hours of age) for subsequent excessive hyperbilirubinemia is feasible by use hour-specific transcutaneous bilirubin.
[DOCX File]MENNONITE COLLEGE OF NURSING
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-- the water-soluble form. also called "Direct". Increase in the direct bili is usually caused by an obstruction or absence of liver bile ducts (ie. biliary atresia or serious hepatic problems). Unconjugated bilirubin-- the fat-soluble form also called “Indirect:. Produced when hemoglobin is broken down, usually in …
[DOC File]RAJIV GANDI UNIVERSITY OF HEALTH SCIENCES
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10. Rogowsk JA, Horbar, J.D. Staiger D.O. Indirect vs direct hospital quality indicators for very low birth weight infants. JAMA 2004; 291 (2) : 202-209. 11. Tarnow-Mordi W, Ogston S, Wilkinson AR, et al. Predicting death from initial disease severity in very low birthweight infants: a method for comparing the performance of neonatal units.
[DOC File]Gastrointestinal MCQ’s
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congenital failure of obliteration of the processus vaginalis is one of the causes of indirect inguinal herniae. direct inguinal herniae rarely incarcerate and strangulate. a Richter hernia is incarceration of a single wall of a hollow viscus. obturator herniae frequently incarcerate. epigastric hernia is of approximately equal incidence by sex. 2.
[DOCX File]MENNONITE COLLEGE OF NURSING
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Increase in the direct bili is usually caused by an obstruction or absence of liver bile ducts (ie. biliary atresia or serious hepatic problems). Unconjugated bilirubin -- the fat-soluble form also called “Indirect:.
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