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[PDF File]Evaluation of Elevated Liver Enzymes
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• Decrease in hepatic uptake by drugs (rifampin) USUALLY NOT HEPATOBILIARY DISEASE Gilbert’s Syndrome • Characterized by elevated levels of unconjugated hyperbilirubinemia • Effects 7% of population • Often misdiagnosed as hepatitis • Bilirubin levels elevated but < 3‐4 mg/dL • …

Drug Induced Liver Injury (DILI)
Drugs used for therapeutic intent may cause serious or ... bilirubin and plasma prothrombin time. Causality is another matter – very difficult ... Elevated levels may reflect injury to liver ...

[PDF File]Assessment of Liver Function and Diagnostic Studies
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• Non-hepatic causes of elevated AST/ALT should be considered if no other cause can be found Aminotransferases • Defined as an impairment in bile flow. • Cholestatic liver profile is characterized by an elevation in alkaline phosphatase with or without an elevation in bilirubin. • Alkaline phosphatase elevation seen in those who are ...

[PDF File]UNDERSTANDING YOUR LAB TESTS
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making it a good general marker for cell injury. An elevated LDH can indicate injury to several different organs or body systems, including the heart, red blood cells, kidney, lungs, white blood cells, muscle, liver, and skeletal muscle. TOTAL BILIRUBIN Bilirubin is an orange-yellow pigment found in bile. Normally levels are low.

[PDF File]Hyperbilirubinemia in the Term Newborn
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Feb 15, 2002 · requires protein binding with albumin. After conjugation in the liver, it is excreted in bile.3,5-7 Newborns produce bilirubin at a rate of approximately 6 to 8 mg per kg per day.

A CASE-BASED SERIES ON PRACTICAL PATHOLOGY FOR GPs
A raised unconjugated serum bilirubin can be due to bilirubin overproduction (i.e. haemolysis), impaired bilirubin uptake or conjugation in the liver (i.e. due to drugs, Gilbert’s syndrome or Crigler-Najjar syndrome). Causes of an elevated conjugated bilirubin include reduced excretion into the biliary system or hepatocyte leakage into serum.

[PDF File]Liver function tests - RACGP
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remain elevated for 2–3 weeks after cessation of heavy drinking or liver injury. Bilirubin increases in both cholestatic and hepatotoxic liver disease. in adults, raised bilirubin is usually predominantly conjugated. unconjugated hyperbilirubinaemia in adults is usually due to Gilbert syndrome or to haemolysis. Gilbert syndrome is a common

Potential Implications of Elevated Liver Enzymes
1. There is evidence of impaired liver synthetic or metabolic function (elevated bilirubin, PT/INR, ammonia, low albumin) 2. There is evidence of cholestasis (elevated direct bilirubin, alkaline phosphatase, GGT) 3. There is evidence of portal hypertension (low platelet count or albumin, ascites on ultrasound) 4. The patient is a neonate or ...

[PDF File]Urinalysis Interpretation
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Vitamin tablets often result in a bright yellow urine, as does the presence of bilirubin (a bile pigment). Red urine may be due to blood, haemoglobin, or beetroot. Iron supplements may cause a dark brown specimen, as might amounts of prophobilin or urobilin (a chemical produced in the intestines) Normal urine is also transparent.

[PDF File]URINE DIPSTICK Multistix® 10SG Operator Competency
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Substances that cause abnormal urine color, such as visible levels of blood and bilirubin and drugs containing dyes (ex. Pyridium), nitrofurantoin (ex. Macrodantin), or riboflavin may affect the readability of the reagent pad areas on the strip.

Drugs that cause elevated bilirubin