Elevated acth and normal cortisol
[DOCX File]A Clinical Approach to the Diagnosis and Treatment of ...
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The “dexamethasone” suppression testing is also a key test in the evaluation of possible Cushing’s; recall that in healthy people, high blood levels of cortisol “turn off” or “turn down” pituitary secretion of ACTH by the normal negative feedback mechanism; dexamethasone is a cortisol-like hormone and is given to patients in this ...
Ohio University
Elevated circulating cortisol levels have also been identified in patients with adrenal tumors [7]. Low cortisol levels are found in primary adrenal insufficiency (e.g. adrenal hypoplasia, congenital adrenal hyperplasia, Addison's disease) and in ACTH deficiency [1,2,8,9]. Due to the normal circadian variation of cortisol levels, distinguishing ...
[DOC File]I. INTENDED USE
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Elevated 24-hour urinary cortisol, serum cortisol. and urinary free cortisol. Dexamethasone suppression - given at 11pm with 8am cortisol level- lack of normal suppression . Initial test given***** Best screening test for . cushing’s disease. Plasma ACTH
[DOC File]3-03-08 Adrenal Cortex Disease
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A majority of patients with fatigue plus other hypocortisolemic symptoms, AM serum cortisol levels
[DOCX File]Clinical case seminar
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Dx - assess cortisol excess, determine if pathologic, and ACTH-dependence: Cortisol excess - see if 24 hr urine cortisol > 100. Pathologic excess - low-dose dexamethasone should suppress cortisol… won’t if diseased. ACTH dependence - is ACTH normal/high (ACTH-dependent), or low (ACTH-independent)
Cushing's Disease | UCLA Pituitary Tumor Program
Congential Adrenal Hyperplasia – Underproduction of cortisol leads to elevated ACTH that leads to hyperplasia. Excess ACTH due to low cortisol – defects in all proteins/enzymes associated with ZF, or to the GC receptor (loss of feedback). 17α-OHsteroids ok , but no cortisol in ZR leads to androgen production and virilization
[DOC File]Biochemistry Diseases (Chapters 27-52)
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Cortisol concentrations were elevated but adrenocorticotropic hormone (ACTH) concentrations were equivocal. The use of antibodies specifically detecting ACTH precursors revealed that plasma ACTH precursors were elevated. Additionally, an ACTH assay with a low cross-reactivity for precursors showed low concentrations of ACTH.
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