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[DOCX File]Drug Information Common to the Class of Extended-Release ...
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Solid oral dosage forms: Swallow tablets and capsules whole: crushing, chewing, breaking, cutting or dissolving may result in rapid release and absorption of a potentially fatal dose of opioid. Some capsules can be opened and pellets sprinkled on applesauce for patients who can reliably swallow without chewing and used immediately.
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[DOCX File]Opioids > 50 mg Morphine Equivalent Daily Dose (MEDD)
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*According to this conversion table, every 90 mg/d (range, 60–134 mg/d) of oral morphine or equivalent converts to approximately 25 mcg/h of transdermal fentanyl (but not necessarily vice versa). Dosage conversions are only approximate.
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[DOC File]Table 4: Intranasal medications and doses for treatment of ...
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Titration is possible every 15 minutes, consider oral medications at 15-20 minutes to kick in as I.N. wears off Sedation Midazolam 0.5 mg/kg. Sufentanil 1.0 to 1.5 ug/kg. Fentanyl 1.5 to 3.0 ug/kg. Ketamine 10 mg/kg. Dexmedetomidine 2-3 ug/kg Always monitor for respiratory depression
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[DOC File]Equianalgesic Chart (Changes in italics)
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Analgesic Dosage Parenteral Oral Fentanyl (Sublimaze() 0.1 - 0.2 mg ----- Hydrocodone ----- 30 mg Hydromorphone (Dilaudid() 1.5 mg 7.5 mg Meperidine (Demerol() 75 - 100 mg 300 mg § (N) Morphine 10 mg 30 mg §§ Oxycodone ----- 20mg § Dosage in this range may lead to neuroexcitability. §§ For a single dose, 10 mg IV morphine = 60 mg oral ...
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[DOC File]Pharmacokinetics and Pharmacodynamics
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To produce a peak fentanyl effect site concentration of 3.0 ng/ml requires 225 g, which will produce a peak effect in 3.6 minutes. This is a clinically reasonable suggestion, compared with the absurd suggestion, based upon V1 and Vdss, of simply picking a dose between 39 and 1080 g. The exact same concept applies to oral dosage.
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[DOC File]Fentanyl Transdermal System (TDS) Informational Summary
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As a general rule, when converting to fentanyl from another opioid, use about 25mcg/h of fentanyl transdermally for every 90 mg of oral morphine equivalent. Appropriate dosage increments should be based on the daily use of supplemental opioids with the equivalency of morphine 45 milligrams/day orally to a 12.5 micrograms/hour increase in the ...
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Fentanyl oral dosage