Fmoc solid phase peptide synthesis
Solid Phase Synthesis | Sigma-Aldrich
2- General procedures for solid phase peptide synthesis Fmoc-based solid phase peptide syntheses (SPPS) were carried out on a Prelude synthesizer from Protein Technologies. Standard side-chain protecting groups were used: Arg(Pbf), Asn(Trt), Asp(O
[DOCX File]spiral.imperial.ac.uk
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All peptide-fluorophore conjugates were purified to >95% purity as judged by analytical scale reinjections.Multidimensional NMR Experiments. BC1. was synthesized as described previously using Fmoc/t-bu solid phase peptide synthesis with an orthogonal protecting group strategy.
[DOC File]This is the title - ResearchGate
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and THF15 have been used as replacements for DMF in peptide bond formations and acetonitrile has also been used as a solvent for Fmoc deprotections in solid-phase peptide synthesis,14 but neither of these are considered to be green solvents.12,13 Recently, the use of 2-MeTHF as a solvent for coupling reactions during solid-phase peptide ...
[DOCX File]Centers for Disease Control and Prevention
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Synthetic protocol of Fmoc-His-OH derivatives and trimeric SAMP-1 using solid phase peptide synthesis (SPPS). (a) DCC/HOBt, MeOH, overnight; (b) i. R1-OH or R2-OH, Tf2O, DIEA, DCM; ii. TFA, TIS, DCM, 2 h; (c) 2 N HCl/1,4-Dioxane; (d) i. 20% piperidine in DMF, 15 min; ii.
[DOC File]ars.els-cdn.com
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Supplemental Material. Continuation: Peptide synthesis and characterization. Stapled peptides, referring to an all-hydrocarbon brace at one (single stapled) or more (e.g. double stapled) positions of the α-helical peptide (1-3), exhibited increased conformational and functional stability, binding affinity, and cell penetration via endocytosis compared to others (1-3).
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During solid-phase peptide synthesis, the aggregation of growing peptides on the resin due to hydrogen-bonded interactions, is thought to be the cause of ‘difficult’ sequences [11-14].
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Firstly, the chemistry should ensure each reaction proceeds to completion without side reactions. In the context of peptide, this goal can be achieved with the Fmoc chemistry from conventional solid phase peptide synthesis (SPPS) for most peptides (Albericio, 2000; Behrendt et al., 2016; Coin et al., 2007; El-Faham and Albericio, 2011).
[DOCX File]White Rose Research Online
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, we synthesized 12 inhibitors via Fmoc-based solid phase peptide synthesis (Scheme 1) [3]. Scheme. 1. Synthetic route for RI-modified inhibitors. The inhibitory activities of newly synthesized inhibitors against HTLV-1 protease are summarized in Table 1. While inhibitors having an . N
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