Genetic causes of dilated cardiomyopathy

    • [DOCX File]GeneDx

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      Heart muscle is flabby and weak for unknown causes (so-called “idiopathic dilated cardiomyopathy” or DCM) Trypanosomiasis (disease caused by the protozoa, Trypanosoma)—rare . Toxicity of doxorubicin (a chemotherapeutic drug) to the heart in dogs. Inadequate levels of thyroid hormone (known as “hypothyroidism”)—rare. Excessive levels of thyroid hormone (known as “hyperthyroidism ...

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    • [DOC File]Dilated Cardiomyopathy:

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      There are three main types of cardiomyopathy: dilated, hypertrophic, and restrictive; or these can be combined. b. Etiology: Dilated cardiomyopathy. is most frequently caused by extensive CAD. It may also result from an acute infection and inflammation of the heart muscle – viral cardiomyopathy is most often from the coxsackie B virus. Other causes include poorly controlled DM or thyroid ...

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    • [DOCX File]Clinical Management of Dilated Cardiomyopathy

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      The modest reductions in RNA levels in the mouse orthologs of two of the known genetic causes of cardiomyopathy in humans (Figure 5G; Ttn and Ryr2) are interesting but difficult to interpret. There no detectable generalised effect on the transcriptome, even for very long transcripts, and thus these reductions in specific transcripts are more likely to represent an early marker of cardiomyocyte ...

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    • [DOCX File]GeneDx

      https://info.5y1.org/genetic-causes-of-dilated-cardiomyopathy_1_b94034.html

      Dilated cardiomyopathy mostly is a disease of large and giant breeds, but it also strikes certain breeds at a much higher rate than other breeds of the same size. The Scottish Deerhound has the highest percentage of affected dogs seen at veterinary hospitals, followed by the Doberman Pinscher, Irish Wolfhound, Great Dane, Boxer, Saint Bernard, Afghan Hound, Newfoundland, Old English Sheepdog ...

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    • Familial Dilated Cardiomyopathy Causes | Stanford Health Care

      gene (encoding Lamin A/C) are a cause of familial DCM characterized by cardiac conduction disturbances (atrioventricular block) with elevated serum creatine kinase levels and in some cases skeletal muscle involvement (limb-girdle or Emery-Dreifuss muscular dystrophy) (17).

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    • [DOCX File]ITPase Deficiency Causes a Martsolf-Like Syndrome With a ...

      https://info.5y1.org/genetic-causes-of-dilated-cardiomyopathy_1_1b9c61.html

      Dilated cardiomyopathy is a grim disease with a poor prognosis. In the absence of transplantation, most people die within 5 years of diagnosis and death is usually due to end stage CHF. The only “curative” treatment is heart transplant. IDIOPATHIC HYPERTROPHIC SUBAORTIC STENOSIS (IHSS) (“HOCM” stands for . hypertrophic cardiomyopathy. IHSS and HOCM are synonymous.) This is a disease of ...

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    • [DOC File]Cardiovascular Disease Packet

      https://info.5y1.org/genetic-causes-of-dilated-cardiomyopathy_1_109739.html

      The 2011 American College of Cardiology Foundation / American Heart Association (ACCF/AHA) guideline for the diagnosis and treatment of hypertrophic cardiomyopathy recommends genetic testing for HCM and other genetic causes of unexplained cardiac hypertrophy in patients with an atypical clinical presentation of HCM or when another genetic condition is suspected to be the cause.8

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    • [DOC File]CARDIOMYOPATHY STUDY GUIDE

      https://info.5y1.org/genetic-causes-of-dilated-cardiomyopathy_1_a81b82.html

      In contrast, with dilated cardiomyopathy the muscular heart is actually thinned from stretching to accommodate abnormally large, dilated heart chambers. While in other species and in other breeds of dogs there are many causes of dilated cardiomyopathy (DCM), in the Doberman the disease is primary, a genetic predisposition, not caused by other medical problems. The primary problem in …

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    • [DOC File]Doberman Dilated Cardiomyopathy

      https://info.5y1.org/genetic-causes-of-dilated-cardiomyopathy_1_19abb4.html

      Dilated cardiomyopathy in dogs is characterized by left- and right-sided enlargement of the lumen of the chambers of the heart; normal coronary arteries; normal (or minimally diseased) atrioventricular valves (that is, the mitral and tricuspid valves); significantly decreased ability to contract the heart muscle; and heart-muscle dysfunction . Genetics. Genetic cause or heritable ...

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    • [DOC File]Homepage | Wiley

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      Treatment for cardiomyopathy and surveillance for progression is critical and is strongly influenced by knowledge of the underlying genetic cause.1-5 Cardiomyopathies are medically actionable disorders with well-established treatments and interventions that can reduce morbidity and improve survival.1-5 Furthermore, cardiomyopathy may have a syndromic cause, such as in Danon disease, Fabry ...

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