Globalrph vancomycin single dose calculator
[PDF File]Acute Kidney Injury with Antibiotic Combinations and ...
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My Hospital Doses Vancomycin… A. Nomogram (based on weight and renal function) B. Pharmacokinetics calculator (e.g., MedCalc, GlobalRPH, in-house build) C. Manual calculations D. 15-20 mg/kg/dose + renal function-dependent frequency E. Predominately provider-dependent ordering
Vancomycin Dosing for Adults - University Health
Switching from intermittent dosing to CI vancomycin o **NOTE** patients on CI vancomycin tend to accumulate vancomycin and require a lower total daily dose than intermittent therapy . o If patient therapeutic on intermittent therapy: Add up total dose of vancomycin and reduce by 10-20% Round to nearest 250 mg
[PDF File]Aminoglycoside Dosing and Monitoring Guidelines for Adult ...
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the last dose and repeat a 10-12 hours post-dose random level. vi. If the level falls within “Q48h” area, the dosing frequency is INT-Q48h. Start new regimen 48 hours from the last dose and repeat a 10-12 hours post-dose random level. vii. If the plotted level falls on a division line, use the more extended dosing frequency
[PDF File]FLAGYL (metronidazole hydrochloride) 500 mg FOR INJECTION ...
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Fecal excretion accounts for 6-15% of the dose. Renal Impairment: Decreased renal function does not alter the single-dose pharmacokinetics of metronidazole. Subjects with end-stage renal disease (ESRD; CL CR =8.1 ±9.1 mL/min) and who received a single intravenous infusion of metronidazole 500 mg had no significant change in
[PDF File]Renal Dosage Adjustment Guidelines for Antimicrobials
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For vancomycin and the aminoglycosides, a pharmacokinetic consult will be performed by the pharmacist, and the ordering physician will be contacted for dosage changes unless ordered as “pharmacy to dose.” If written as “pharmacy to dose” dosing will be ordered by the pharmacist.
[PDF File]Adult Sepsis Empiric Antibiotic Guidelines
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help with vancomycin dosing and antibiotic dosage adjustments in renal failure) Vancomycin load (20 mg/kg x 1, max 2 g) + maintenance (typically 15 mg/kg q8-12hours) Ceftriaxone 2 g IV every 24 hours, Ceftazidime 2 g IV every 8 hours, Cefepime 2 g IV every 8hours
[PDF File]Predicted Versus Actual Vancomycin Trough in a Home ...
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A retrospective chart review was completed of all adult patients on vancomycin for any indication at one home infusion pharmacy from January 2018 to November 2019. Patients without pharmacokinetics assessments from GlobalRPh, or vancomycin troughs were excluded. The primary measure was the difference between the actual and predicted trough.
[PDF File]Critical Care Intravenous Drug Administration Guide
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Adjust dose in patients
[PDF File]Vancomycin Monitoring and Dosing Guideline
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NB: Do NOT hold next vancomycin dose while waiting for results of plasma levels unless there is a specific order to do so, e.g. because of concerns of toxicity/adverse events and/or significant decline in kidney function. *Steady state (SS) occurs in 4 to 5 half-lives and can be estimated for vancomycin by using the following equations: k e
[PDF File]Learning Objectives
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GlobalRPh AUC 24: AUC 24 = (total daily dose)/CL, where CL = K ×V Vancomycin-calculator.com AUC 24: AUC ... single-sample Bayesian methods versus trough dosing • Break-even for Bayesian after treating 41 patients for at least 48 hours •Cost savings associated with Bayesian calculator use2
[PDF File]Curve Your Enthusiasm: Using AUC:MIC pharmacokinetics to ...
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vancomycin and factors which may impact efficacy or dosing of this drug. 2. Describe two methods of AUC:MIC vancomycin optimization and the pros/cons associated with each method. 3. Apply a linear/logarithmic trapezoidal AUC calculation model to vancomycin dosing in a patient case. •Technician: 1. Describe the mechanism of action of ...
[PDF File]Antibiotic Renal Dosing List - Remedi SeniorCare
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CrCl 15-30 mL/min: Reduce recommended dose by 50% CrCl < 15 mL/min: Use is not recommended Valcyclovir (Valtrex) CrCl 10-50 mL/min: Administer the full dose every 12-24 hours depending on indication CrCl < 10 mL/min: 500 mg PO every 24 hours Vancomycin oral (Vancocin) No adjustment required
[PDF File]INVANZ (ERTAPENEM FOR INJECTION) For Intravenous or ...
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The recommended dose of ertapenem in patients with CLCR ≤30 mL/min/1.73 m 2 is 0.5 grams every 24 hours. Following a single 1 g IV dose given immediately prior to a 4 hour hemodialysis session in 5 patients with end-stage renal insufficiency, approximately 30% of the dose was recovered in the dialysate. A
Auc Mic Ratio As A Tool In Determining Effectiveness Of
Vancomycin Advanced AUC Calculator - GlobalRPH Vancomycin Monitoring (ASHP 2020) See source below for the complete guidelines. "In patients with suspected or definitive serious MRSA infections, an individualized target of the AUC/MIC BMD ratio of 400 to 600 (assuming a vancomycin MIC BMD of 1 mg/L) should be advocated to achieve clinical
[PDF File]VANCOMYCIN DOSING AND MONITORING GUIDELINES
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• Consider alternate sources of vancomycin that may be contributing to measured serum concentrations (e.g., vancomycin instille d intra-operatively, or added to cement during orthopedic surgery) • If the trough is below the target level, ensure the dose is 15-20 mg per kg actual body weight, and consider
[PDF File]INTRAVENOUS VANCOMYCIN DOSING/MONITORING IN ADULTS OBJECTIVE
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1. Give loading dose of 25 mg/kg x 1 dose (max 2 g) 2. Check a vancomycin level at 24-48 hours post-dose or with am labs on the day of the next hemodialysis session (if applicable) to obtain an estimated steady state level a) High flux filters in HD will remove ~ 20-40% of the vancomycin dose during dialysis.
Vancomycin in peritoneal dialysis: Clinical pharmacology ...
128 Movement of vancomycin from the peritoneum cavity to plasma is based on Fick’s Law (figure 129 1). Middle molecular weight solutes such as vancomycin (1,486 g/mol) are dependent on dwell time 130 during PD for absorption into the plasma. Based upon a single dose study of six non-infected subjects on
[PDF File]Vancomycin per Protocol
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Other vancomycin doses will still be visible if you want to manage off-protocol Not finalized. Image above is a sample screenshot, pending further modifications. Confidential –For Discussion Purposes Only Initial Dosing* 9 *Dose using TBW; Maximum single dose = 2.5 gm
[PDF File]INTRAVENOUS VANCOMYCIN DOSING AND MONITORING GUIDELINES
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ADULT INTRAVENOUS VANCOMYCIN DOSING AND MONITORING GUIDELINES DOSE: Adult dose: (based on actual body weight (ABW))*,^: 12.5 to 15 mg/kg (round off to nearest 250 mg increment, to max dose of 1500mg; see dosing table) * If ABW is > 30% ideal body weight (IBW), then use adjusted body weight = IBW + 0.4(Total body weight - IBW) IBW Males = 50 kg + 2.3 kg for each inch > 60 inches IBW Females ...
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