Glucocorticoid receptor resistance
[DOCX File]University of Edinburgh
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In corticotroph cells, glucocorticoid receptor proteins (GRs) require direct interaction with Hsp90 to fold and produce mature GRs. One function of GR in the cell is to suppress the transcription of proopiomelanocortin (POMC), which is a precursor to adrenocorticotropin …
Microreviews in Cell and Molecular Biology
Oakley, R.H., Cidlowski, J.A. (2011). Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissue-specific actions of glucocorticoids. J …
[DOCX File]A Clinical Approach to the Diagnosis and Treatment of ...
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Antidepressants which increase serotonin cause increases in glucocorticoid receptor number and can reverse the increased glucocorticoid secretion seen in depressed humans and in transgenic mice who have been genetically altered to demonstrate reduced glucocorticoid receptors and increased glucocorticoid secretion (partial GR knockout) (Barden ...
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A number of studies in animal models have focused on epigenetic regulation of expression of the glucocorticoid receptor (GR). When GR is expressed at high levels in a given tissue, that tissue becomes more sensitive to glucocorticoid signaling, i.e., lower concentrations of glucocorticoid are necessary for a given level of tissue response.
ORIC Pharmaceuticals, Inc.
Glucocorticoid signaling is context-dependent, and in certain scenarios glucocorticoid receptors (GR) are able to engage with other members of the nuclear receptor subfamily. Glucocorticoid signaling can exert sexually dimorphic effects, suggesting a possible interaction with androgen sex hormones.
Fetal Programming and Fetal Psychology
glucocorticoid receptor, which has been linked to resistance to multiple classes of cancer therapeutics across a variety of solid tumors. ORIC-101 is currently in two separate Phase 1b trials of ORIC-101 in combination with. Xtandi (enzalutamide) in metastatic prostate cancer and (2) Abraxane (nab-paclitaxel) in advanced or metastatic solid tumors.
[DOCX File]U.S EPA Web Server
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Chronic excessive CRH production by the hypothalamus leads to downregulation of the pituitary ACTH response and glucocorticoid-receptor resistance. Cohen S, Janicki-Deverts D, Doyle WJ, Miller GE, Frank E, Rabin BS, Turner RB. Chronic stress, glucocorticoid receptor resistance…
Syndromes of Glucocorticoid Resistance
glucocorticoid receptor, which has been linked to resistance to multiple classes of cancer therapeutics across a variety of solid tumors. ORIC-101 is currently in two separate Phase 1b trials of ORIC-101 in combination with (1) Xtandi (enzalutamide) in metastatic prostate cancer and (2) Abraxane (nab-paclitaxel) in advanced or metastatic solid ...
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