Glucocorticoid receptor
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Classical MOA involve binding of GC receptor directly to DNA, Non-classical MOA (majority) = interaction of GR with DNA binding protein. Transactivation can occur via Simple GRE (Cl), Composite GRE (Cl+NC), or Tethering (NC) Transrepression can occur via Nullified (n) GRE (Cl), Competitive nGRE, Tethering nGRE, or Composite nGRE. DEFICIENCY via . 1
[DOC File]Glucocorticoids
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Thus, the system is primarily assumed in a dynamic equilibrium state. Three elemental equilibrium constants describe the binding of ligand, cofactors, and DNA to free glucocorticoid receptor (Ka, KC, and KD, respectively). These equilibrium constants can be altered by the presence of other or others partners previously bound to receptor.
Glucocorticoid receptor - an overview | ScienceDirect Topics
The name glucocorticoid derives from their role in the regulation of the metabolism of glucose, their synthesis in the adrenal cortex, and their steroidal structure.GCs cause their effects by binding to the glucocorticoid receptor (GR). The activated GR complex, in turn, up-regulates the expression of anti-inflammatory proteins in the nucleus ...
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In corticotroph cells, glucocorticoid receptor proteins (GRs) require direct interaction with Hsp90 to fold and produce mature GRs. One function of GR in the cell is to suppress the transcription of proopiomelanocortin (POMC), which is a precursor to adrenocorticotropin (ACTH), a corticotroph stress hormone (1).
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