Half life of a drug
[DOC File]MCQs – Pharmacodynamics & Pharmacokinetics
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The “classic” method of describing the offset of drug effect is to use the terminal half-life. This is not a good idea for drugs described by multicompartmental pharmacokinetics, because the half-life relates only to 1 parameter, (, while all 6 parameters in equation 1 influence the rate of offset of drug effect.
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25. The half life of a drug with a Vd of 200ml/70kg and clearance of 10ℓ/hr/70kg is. a. 10 hours. b. 14 hours. c. 20 hours. d. 40 hours. e. Indeterminate Analgesics/Toxicology MCQs - Answers. 1 July 2004 . 1. c. 2. a. 3. e. 4. c. 5. a. 6. b. 7. c. 8. a. 9. e. 10. a. 11. b. 12. d. 13. d. 14. a. 15. c. 16. a. 17. c. 18. e. 19. c. 20 b. 21. c. 22. b. 23. c. 24. b. 25. b
[DOC File]Pharmacokinetics and Pharmacodynamics
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Drug half life (t½ ) is the amount of time it takes for one half of an administered drug to be lost through biological process (metabolism and excretion) for most drugs, elimination follows and exponential time course with a constant half-life independent of [plasma] = first-order kinetics
[DOC File]DRUG ABSORPTION, DISTRIBUTION AND ELIMINATION ...
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47) A drug has a half life of 8 hours. How much of the drug remains after 24 hours? Feedback: The level of drug halves every eight hours. 50% is left after 8 hours, 25% after 16 hours, 12.5% after 24 hours, 6.25% after 32 hours, 3.125% after 40 hours and 1.5625% after 48 hours. Page reference: 154. a. 25% *b. 12.5%. c. 6.25%. d. 1.56%
[DOC File]Pharmacokinetics II Wk 14 LO’s
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Regarding benzodiazepines, the beta half-life plays a role in where the drug is a short, medium, or long-acting benzodiazepine. Therapeutic half-life is the time to inactivate 50% of the substance whereas the elimination half-life is the time to eliminate 50% of a single dose of a substance from the body. Answer Location: Page 12. 28.
[DOC File]Analgesics/Toxicology MCQs
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The drug follows the kinetics of a first order one-compartment model and has an elimination half-life of 3 hours with an apparent volume of distribution of 100 mL/kg. Problem 5 A 170 mg dose of cinoxin was given to a group of patients and the following data was obtained.
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The half-life is related to k and is defined as the time it takes for the drug concentration to fall to half its original value. Therefore 50% of the dose will be eliminated in one half-life, 75% in two half-lives and 97% in 5 half-lives. The decline in drug concentrations is exponential as expressed as follows; Cp2 = …
[DOC File]Introduction to Clinical Pharmacokinetics
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4) Half-life [Half_Life] Half-life is defined as a time at which concentration reaches 50% of its initial value. The formula to calculate the half-life is as follows: t1/2 = ln(2) / ElimRateConst. Where, t1/2 = Half-life. ElimRateConst = Elimination rate constant. ln = Natural logarithm
What do you mean by the half life of a drug?
5. What is the half life of a drug with a volume of distribution of 100ℓ/70kg and a clearance of 7ℓ/hr/70kg. a. 5 hours. b. 10 hours. c. 12.5 hours. d. 15 hours. e. 20 hours 6. All of the following drugs exhibit flow dependent elimination EXCEPT. a. Atenolol. b. Isoniazid. c. …
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The elimination half-life of the drug is 4 hours and the volume of distribution is 50L. Which of the following is(are) correct? a. After 4 hours, the approximate plasma drug concentration is 1.73 (g/ml. b. After 8 hours, the approximate plasma drug concentration is 2.60 (g/ml. c. After 24 hours, the approximate plasma drug concentration is 3.46 ...
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