Https doi org 10 1016 j euroecorev 2023 104637
[PDF File] Bacterial molecular syringe for drug delivery - Cell Press
http://5y1.org/file/1408/bacterial-molecular-syringe-for-drug-delivery-cell-press.pdf
Different protein-delivery tools are being actively developed for efficient drug delivery into host cells. A recent study by Kreitz et al. in reported a syringe-like protein delivery vector engineered from natural endo-. Nature. symbiotic bacteria for potential human use. One of the major hurdles for drug devel-opment is the efficient-delivery ...
[PDF File] Cancer-cell-derived fumarate suppresses the anti-tumor capacity …
https://www.cell.com/cell-metabolism/pdf/S1550-4131(23)00171-7.pdf
Article Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment Jie Cheng,1,2,8 Jinxin Yan,1,2,8 Ying Liu,3,8 Jiangzhou Shi,4,8 Haoyu Wang,1,2 Hanyang Zhou,1 Yinglin Zhou,3 Tongcun Zhang,4 Lina Zhao,1 ,2 7 Xianbin Meng,5 Haipeng Gong,1 ,6 Xinxiang Zhang,3 * Haichuan Zhu,4 * and Peng …
[PDF File] The pyrimidinosome: Orchestrating pyrimidine biosynthesis and ...
https://www.cell.com/molecular-cell/pdf/S1097-2765(23)00527-0.pdf
A recent study by Yang et al.1uncovers the pyrimidinosome, a multienzyme complex where enzymes from different subcellular compartments collaborate to enable efficient pyrimidine biosynthesis and ferroptosis defense, highlighting the remarkable adaptability of cellular metabolism and new therapeutic opportunities.
[PDF File] Network perturbation-based biomarkers of depression and …
https://www.cell.com/cell-reports-medicine/pdf/S2666-3791(23)00205-7.pdf
Future work implementing perturbation-based approaches to study depression-related functional brain net-works and their dynamics should focus on the identification of optimal parameter settings for effectively engaging these networks and the investigation of state dependency of network activation and modulation by, for example, cognitive and ...
[PDF File] How hummingbirds hover: Natural selection for energetics of …
https://www.cell.com/molecular-cell/pdf/S1097-2765(23)00156-9.pdf
Lessons from the natural selection for this mutation are applied to physiology and medicine. Hummingbirds are the only birds capable of sustained hovering flight. The meta-bolic demand of hovering comes with a high energy requirement, with a whole body O2 consumption rate of 700 mL kg 1 min 1.2 This is the highest peak , metabolic rate …
[PDF File] Designing of anisotropic gradient surfaces for directional liquid ...
https://www.cell.com/the-innovation/pdf/S2666-6758(23)00136-4.pdf
Designing of anisotropic gradient surfaces for directional liquid transport: Fundamentals, construction, and applications Lanlan Hou,1,2,3 Xiaofei Liu,1 Xinran Ge,1 Rongjun Hu,1,4 Zhimin Cui,1 N€u Wang, 1,* and Yong Zhao1 1Key Laboratory of Bioinspired Smart Interfacial Science and Technology of Ministry of Education, Beijing Key Laboratory of …
[PDF File] P Re https://doi.org/10.1016/j.patcog.2022.109025
https://arxiv.org/pdf/2103.03483.pdf
96.65 ± 0. 06 %, 87.10 ± 0. 02 %, 84.45 ± 0. 05 % and 92.57 ± 0. 05 % on ESC- 10, ESC-50, US8K and AE, respectively. These performances are also very close to the overall SOTA for the mentioned benchmarks (see Table 1 ). We then compress ACDNet using a novel network- independent compression approach to obtain an extremely small
[PDF File] Brain organoids restore cortical damage - Cell Press
http://5y1.org/file/1408/brain-organoids-restore-cortical-damage-cell-press.pdf
These findings illustrate that transplanted brain organoids can compensate for cortical injuries and integrate functionally into the host brain circuitry network. The work, therefore, signifies a major step for-ward in using stem-cell-derived neural tis-sues for cortical repair.
ADDITIONS AND CORRECTIONS
https://www.jbc.org/article/S0021-9258(23)00252-1/pdf
Andrew Bell, Emmanuele Severi, C. David Owen, Dimitrios Latousakis, and Nathalie Juge. In the JBC Reviews article entitled “Biochemical and structural basis of sialic acid utilization by gut microbes arrows on Figure 6 should ” be adjusted. The correct Figure 6 …
[PDF File] HK2: Gatekeeping microglial activity by tuning glucose …
https://www.cell.com/molecular-cell/pdf/S1097-2765(23)00149-1.pdf
A new study by Hu et al.1 delineated a critical role of HK2 in governing glycolytic flux and mitochondrial activity, thereby modulating microglial functions in maladaptive inflammation in brain diseases. As a key player in glucose metabolism, hexokinases (HKs) phosphorylate im-ported glucose to produce glucose-6-phosphate (G-6-P).
[PDF File] CircR-looping the leukemic translocations: The cause of MLL ...
https://www.cell.com/molecular-cell/pdf/S1097-2765(23)00421-5.pdf
MLL. trigger RNA polymerase pausing, driving oncogenic gene fusions via endogenous RNA-directed DNA damage. Translocations involving the mixed lineage leukemia (MLL) gene identify a unique group of acute leukemias with poor prog-noses.2 Most MLL translocations associ-ated with hematologic malignancies can be mapped to an 8.3 kb …
Evidence-Based Strategies for Clinical Organizations to Address COVID ...
https://www.mayoclinicproceedings.org/article/S0025-6196(20)31487-7/pdf
COVID-19, coronavirus disease 2019. context of organization-level and interpersonal-level interventions drawing upon effective and evidence-based commu-nication strategies, can optimize efforts to address hesitancy in clinical settings. Table 1 summarizes evidence-based strate-gies and offers specic examples. fi.
Summary brief
https://tdr.who.int/docs/librariesprovider10/sort-it/ntd/gp11-endalamaw-g-evidence-brief.pdf?sfvrsn=83953c4a_3
Summary brief Date, 24/10/2023, Vol 0.1, Num 0.01 Combined Ivermectin, Albendazole and Azithromycin Mass Drug Administration is Safe and Acceptable This is a policy brief to show the
[PDF File] Previews HidingfromallogeneicNKcellsandmacrophagesbya …
https://www.cell.com/cell-stem-cell/pdf/S1934-5909(23)00367-3.pdf
Immune attack by natural killer (NK) cells is a major hurdle for allogeneic off-the-shelf cell therapy, especially when HLA molecules are removed. Gravina et al.1 utilized a membrane-anchored single-chain antibody (scFv) as a synthetic receptor, named ‘‘synthetic immune checkpoint engager,’’ to prevent attack from NK cells and macrophages.
Peer-reviewed and published in: Applied Acoustics (Elsevier), DOI ...
http://export.arxiv.org/pdf/2307.00084
2.7 Dynamic range and resolution of detail 10 2.8 Sound produced by the ear 10 Masculinity-femininity dependence of OAEs and AEPs 3 NEURAL PROCESSING IN SUBCORTICAL 11 AUDITORY PATHWAYS 3.1 DCN and elevation localization 12 3.2 Reflection-delay mechanism for elevation localization 12 3.3 AVCN and signal …
[PDF File] The microbial code and cancer immunotherapy outcome - Cell Press
https://www.cell.com/cell-host-microbe/pdf/S1931-3128(23)00255-X.pdf
The contribution of the gut microbiome to immune responsiveness is largely unknown. In a recent Nature Medicine article, Stein-Thoeringer et al. assess the microbiome configuration before cancer immunotherapy and determine the impact of antibiotic-masked microbial features on therapy’s effectiveness. This provides a framework for identifying ...
[PDF File] Rise of synthetic yeast: Charting courses to new applications - Cell …
http://5y1.org/file/1408/rise-of-synthetic-yeast-charting-courses-to-new-applications-cell.pdf
The Synthetic Yeast Genome Project (Sc2.0) consortium labors at the frontier of our human-yeast partnership, as re-. searchers endeavor to fully rewrite the yeast genome to optimize downstream utility. The benefits of the project fall into two categories: (1) tools to assemble and manipulate genomes and (2) the syn-thetic yeast cell itself as a ...
[PDF File] Solving a molecular cryptogram for the human fingerprint - Cell …
https://www.cell.com/cell/pdf/S0092-8674(23)00090-9.pdf
P.M. is supported in part by NIAMS/NIH R01AR076420. M.I. is supported in part by R01 the biological patterns found after EDAR nents of the fingerprint pattern (furrows). AR059768 and R01 AR074995. and BMP perturbation. In this study, the genes and proliferation How do ridges propagate over volar pattern that regulate primary ridge forma-.
Pancreatic cancer: ESMO Clinical Practice Guideline for diagnosis ...
https://www.annalsofoncology.org/article/S0923-7534(23)00824-4/pdf
SPECIAL ARTICLE Pancreatic cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up5 T. Conroy1,2, P. Pfeiffer3, V. Vilgrain4,5, A. Lamarca6, T ...
[PDF File] Coacervate droplets: Emerging vehicles for intracellular delivery
https://www.cell.com/matter/pdf/S2590-2385(23)00250-3.pdf
Bohang Wu,1 Peng Ding,1 Mingwei Wang,1 Martien A. Cohen Stuart,1,* and Junyou Wang1,*. Coacervate droplets have emerged as intracellular delivery vehicles, but the detailed internalization mechanism has remained unclear. This preview highlights a recent breakthrough, revealing the endo-cytosis of coacervates and relevant control factors …
[PDF File] Lactobacillus plantarum-derived indole-3-lactic acid ameliorates ...
https://www.cell.com/cell-metabolism/pdf/S1550-4131(23)00141-9.pdf
(I) Body weight was measured and recorded during the model-building process, n = 10 mice/group. (J and K) Histogram showing numbers and size distribution of tumors, n = 10 mice/group. (L) The representative images of colon tumors, n = 10 mice/group. (M and N) The weight of liver and spleen of mice from (H) at the endpoint, n = 10 mice/group.
[PDF File] Cadenza ad libitum: cGAS and STING showcase their versatile ...
https://www.cell.com/molecular-cell/pdf/S1097-2765(23)00073-4.pdf
Cadenza ad libitum: cGAS and STING showcase their versatile virtuosities in the Ca2+-dependent rescue of stalled replication forks Jungsan Sohn1,* 1Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA *Correspondence: jsohn@jhmi.edu
[PDF File] The natural rate of unemployment and the NAIRU
http://pure-oai.bham.ac.uk/ws/portalfiles/portal/206463266/BackhouseR2023Natural.pdf
DOI: 10.1016/j.euroecorev.2023.104563 License: Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND) Document Version Publisher's PDF, also known as Version of record Citation for published version (Harvard): Backhouse, R, Forder, J & Laskaridis, C 2023, 'The natural rate of unemployment and the NAIRU', European
[PDF File] Liquid–liquidphaseseparationinplants:Advances and perspectives …
https://www.cell.com/plant-communications/pdf/S2590-3462(23)00191-8.pdf
2021; Field et al., 2023). From 2018 to 2023, a growing number of studies have shown that LLPS has crucial effects on plant development, flowering, photomorphogenesis, and stress resistance (Figure 1). Most of these studies have targeted Arabidopsis thaliana. The roles of LLPS in other plants, especially crops, have apparently been neglected ...
[PDF File] Highly efficient bifacial single-junction perovskite solar cells
https://www.cell.com/joule/pdf/S2542-4351(23)00224-6.pdf
By optimizing the transparent rear electrode, we achieved highly efficient single-junction bifacial perovskite solar cells (PSCs). Under concurrent bifacial illumination conditions, we achieved stabilized power outputs of 26.9, 28.5, and 30.1 mW/cm2under albedos of 0.2, 0.3, and 0.5, respectively—surpassing state-of-the-art monofacial single ...
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