Hyaluronidase for amiodarone extravasation
Guideline for the Treatment and Care of Peripheral ...
Extravasation- inadvertent administration of vesicant medication or fluid into the surrounding tissues. ... Inject hyaluronidase 200 units/mL by subcutaneous or intradermal route using a 25 gauge needle in 5 aliquots of 0.2 mLeach around the …
[PDF File]IV EXTRAVASATION MANAGEMENT
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Extravasation is defined as the inadvertent administration of a drug or IV fluid into the surrounding tissue instead of into the intended vascular pathway. Extravasation has the potential to cause tissue necrosiswhich may result in the loss of the
[PDF File]GUIDE TO EXTRAVASATION MANAGEMENT IN ADULT & …
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Hyaluronidase (Amphadase [bovine])2 Preparation: Use solution as provided (150 unit/1 mL vial); do not dilute further. Inject subcutaneously or intradermally into the extravasation site using a 25-gauge needle or smaller.
[PDF File]Extravasation/Infiltration Management Chart
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Hyaluronidase Phentolamine Dexrazoxane Sodium Thiosulfate Acyclovir* X X * Vesicants are highlighted in this color Allopurinol X Aminophylline* X X Amiodarone X Amphotericin B X Arginine HCL X X Arsenic Trioxide X X Bleomycin X Infiltration Grading Scale Busulfan X X Grade Clinical Criteria Calcium Chloride* X X 0 € No symptoms Calcium ...
[PDF File]3364-133-125 Treatment of Intravenous Non …
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edge of the extravasation at the leading edge in a clockwise manner 3. Use a new 25‐gauge needle for each injection Apply dry, cold compress Amiodarone ‐Supportive management ‐Hyaluronidase (refractory cases) 1.
[PDF File]GUIDE TO EXTRAVASATION MANAGEMENT IN …
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extravasation with Savene (dexrazoxane): results from two propective clinical multicentre studies. Annals of Oncology, 2007; 18: 546-550. Hyaluronidase . Sodium thiosulfate. Phentolamine. SPECIFIC SUBSTANCES WARM OR COLD THERAP Y ANTIDOTE . Apply warm packs . for 15-20 minutes at least four times a day least four times a . Apply warm packs for ...
[PDF File]Extravasation Management Reference Sheet
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extravasation Digoxin Heat Hyaluronidase OR 150 units Give via 5-10 SQ or TD injections into area of extravasation Hydrocortisone 50-200 mg Dilute with NS, Inject SQ or TD at give via 5-10 SQ or TD injections into area of extravasation Dobutamine Heat Nitroglycerin 2% paste n/a Apply thin layer to area of extravasation q 6 hr x 24 hr ...
[PDF File]An update on extravasation: basic knowledge for clinical ...
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The amiodarone extravasation prompted the urgent development of a hospital-wide protocol. This protocol includes information about non- ... Hyaluronidase is an enzyme that hydrolyses hyaluronic acid. Hyaluronic acid is an import-ant part of the skin and tissue, and by break-
[PDF File]MANAGEMENT OF EXTRAVASATION
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extravasation. DO NOT exceed 0.1- 0.2mg/kg or 5mg total. If dose is effective, normal skin color should return to the blanched area within 1 hour None Amiodarone Hyaluronidase (Vitrase, Amphadase, Hydase, Hylenex) Nitropaste 1” 15 units/mL in 0.9% sodium chloride Administer 5 SQ injections of 0.2 mL each Q1H for the first 4 hours, then Q4H X ...
[PDF File]3364-133-125 Treatment of Intravenous Non-Chemoterapeutic ...
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edge of the extravasation at the leading edge in a clockwise manner 3. Use a new 25‐gauge needle for each injection Apply dry, cold compress Amiodarone ‐Supportive management ‐Hyaluronidase (refractory cases) 1.
Management of Extravasation Injuries: A Focused Evaluation ...
relief. Intradermal hyaluronidase has been effective for hyperosmotic extravasations, although its use lar-gely depends on the risk of tissue injury and the severity of extravasation. Among the hyperosmotic agents, calcium extravasation is distinctive because it may present as an acute tissue injury or may possess delayed clinical manifestations.
[PDF File]Appendix B: Vesicant/Irritant and Extravasation Management ...
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4. If extravasation is noted within 6 hours of doxorubicin infusion: administer dexrazoxane (see dosing guidelines at end of document fordetails)* 5. If extravasation is noted more than 6 hours after doxorubicin infusion: administer topical DMSO (see dosing guidelines at end of document for details)* 6.
MANAGEMENT OF EXTRAVASATION: TREATMENT SUMMARY
• Reconstitute 1500iu of Hyaluronidase with 1ml Water for Injection. • Give this Hyaluronidase solution in 0.1- 0.2ml subcutaneous injections at 6 to 8 sites around the circumference of the extravasation area. • Apply a HOT pack for 24 hours. Remove the pack every 3 hours for 20 to 30 minutes replace with a fresh pack.
[PDF File]Guidelines For Treatment of Contrast Interstitial ...
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e) Make some estimate of extravasation volume and content (e.g. contrast type, concentration and if additional substances (e.g. saline, air, blood e tc.) were included. f) There is no good evidence that hyaluronidase injections are of any advantage with the osmolality of routinely used present non-ionic contrast materials.
Guideline for the Treatment and Care of Peripheral ...
Extravasation- inadvertent administration of vesicant medication or fluid into the surrounding tissues. ... Inject hyaluronidase 200 units/mL by subcutaneous or intradermal route using a 25 gauge needle in 5 aliquots of 0.2 mLeach around the periphery of the extravasated area; change the needle ...
[PDF File]An update on extravasation: basic knowledge for clinical ...
https://info.5y1.org/hyaluronidase-for-amiodarone-extravasation_1_5e454d.html
The amiodarone extravasation prompted the ... Hyaluronidase is an enzyme that hydrolyses hyaluronic acid. Hyaluronic acid is an import-ant part of the skin and tissue, and by break-
[PDF File]Amiodarone Peripheral Infusion Guidelines
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Assure no other medication is injected or infusing with Amiodarone • Assure you always have two lines. One for the Amiodarone and one for other medications the patient may need. 2. Assess the IV site prior to infusion • Assess for pain, redness, and assure an adequate flush with 10 mL normal saline.
[PDF File]Irritants and Vesicants Guide to Intravenous ...
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Amiodarone Vesicant Monitor No (E, F) Yes Boluses should be diluted if giving for ... Propofol Irritant Yes Yes Yes Case reports of extravasation injury Thiopental Irritant Yes Yes Yes Other agents Albumin Irritant Yes Yes Yes Aminophylline Vesicant Monitor No (A) Yes Dantrolene Vesicant Monitor No (E, F) Yes Central line preferred, do not wait ...
[PDF File]Revision des SOPs concernant l’aseptique
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Hyaluronidase Mechanism of action Degrades hyaluronic acid, breaks down subcutaneous tissue bonds promoting drug diffusion through the interstitial space and enhances the absorption of injected substances. For Vinca alkaloids + heat Paclitaxel How 150 UI up to 1500 UI sc around the affected area depending on size of extravasation
[PDF File]Guideline for the Management of Extravasation
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Extravasation is a well-recognised complication of intravenous (IV) chemotherapy administration, but in general is a condition that is often under-diagnosed, undertreated and under-reported (Stanley 2002). The incidence of extravasation is estimated to be between 0.5 and 6.0% of cytotoxic drug administration (Kassner ...
[PDF File]2019.11.02 - 10am - Graham Klink - Handout
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Hyaluronidase Dimethyl sulfoxide ... Extravasation of cytotoxic agents occurs at a rate of 0.01‐6.5% Incidence of non‐cytotoxic agent extravasation is largely unknown ... Amiodarone Gentamicin Ketamine Labetalol Lorazepam Ondansetron Promethazine Amphotericin Ceftriaxone Cefepime
[PDF File]GUIDE TO EXTRAVASATION MANAGEMENT IN ADULT & PEDIATRIC ...
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extravasation with Savene (dexrazoxane): results from two propective clinical multicentre studies. Annals of Oncology, 2007; 18: 546-550. Hyaluronidase . Sodium thiosulfate. Phentolamine. SPECIFIC SUBSTANCES WARM OR COLD THERAP Y ANTIDOTE . Apply warm packs . for 15-20 minutes at least four times a day least four times a . Apply warm packs for ...
[PDF File]Guidelines for the Management of Extravasation of a ...
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Extravasation is the accidental leak age of any liquid from a vein into the surrounding tissues. In terms of cancer therapy, extravasation refers to the inadvertent infiltration of systemic anti-cancer therapies (SACT) into the subcutaneous or subdermal tissues surrounding the administration site (Perez-Fidalgo et al, 2012).
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