Immune checkpoint inhibitor toxicity

• files-profile.medicine.yale.edu

  Jun 05, 2021 · Phase II randomized study of ramucirumab plus pembrolizumab versus standard of care for advanced non-small cell lung cancer previously treated with a checkpoint inhibitor: Toxicity update (Lung-MAP non-matched sub-study S1800A).

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• [DOCX File]Australian Public Assessment Report for Atezolizumab

  https://info.5y1.org/immune-checkpoint-inhibitor-toxicity_1_8f109f.html

  At the time of the submission, TGA had recently approved nivolumab, the first PD-1 immune checkpoint inhibitor, for use as a second line treatment of metastatic NSCLC. As outcomes are poor for patients with previously treated, advanced or metastatic NSCLC additional effective and tolerable treatment options are needed.

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• [DOCX File]Introduction and Welcome - Cancer

  https://info.5y1.org/immune-checkpoint-inhibitor-toxicity_1_8db92c.html

  AST-008 is designed to enter and activate immune cells to treat solid tumors in combination with immune checkpoint therapeutic agents (e.g., pembrolizumab). Outcomes in a Phase 1 trial with healthy volunteers found no adverse effects and the activation of cellular immunity (% of CD69+ NK and T-cells) in response to subcutaneous injection of AST ...

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• Journal for ImmunoTherapy of Cancer | A BMJ Oncology Journal

  24.Biondani P, De Martin E, Samuel D. Safety of an anti-PD-1 immune checkpoint inhibitor in a liver transplant recipient. Annals of Oncology. 2018;29(1):286-7. 25.Owonikoko TK, Kumar M, Yang S, Kamphorst AO, Pillai RN, Akondy R, et al. Cardiac allograft rejection as a complication of PD-1 checkpoint blockade for cancer immunotherapy: a case report.

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• [DOCX File]Nova Scotia Health Authority

  https://info.5y1.org/immune-checkpoint-inhibitor-toxicity_1_8c458e.html

  I wanted to bring to your attention that our mutual patient is receiving an immune checkpoint inhibitor (CPI) as part of his/her cancer treatment and as such is at risk for immune-related toxicities which may be life threatening and require urgent assessment and management.

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