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[PDF File]Cannabinoid Quantitation Using an Agilent 6430 LC/MS/MS
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D9-THC, and the primary (inactive) metabolite is 11-nor-D9-tetrahydrocannabinol-9-carboxylic acid (carboxy -THC). Another (active) metabolite of forensic interest is 11-hydoxy- D9-tetrahydrocannbinol (OH-THC). A mathemati-cal model using THC and carboxy-THC concentrations has been explored as a means of estimating time of last use of cannabis [4].
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[PDF File]Detection of Conjugated 11-nor- ∅∅9-Tetra-hydrocannabinol ...
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drocannabinol (THC), is rapidly oxidized to 11-hydroxy- ∅∅9-tetrahydrocannabinol (11-OH-THC) and then to the inactive metabolite, 11-nor- ∅9-tetrahydrocannabinol-9-carboxylic acid (THCA). In some biological matrices, these undergo further metabolism and conjugation to form glucuronides, which are
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[PDF File]Interpretation of Workplace Tests for Cannabinoids
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target analyte in urine an inactive THC metabolite that may Tetrahydrocannabinolic acid (THCA, Δ9-THCA, 2-COOH-THC), is the inacve biosynthec precursor of tetrahydrocannabinol (THC) and found in the Cannabis plant. Tetrahydrocannabinol (THC), or more precisely its main isomer (−)-trans-Δ9-tetrahydrocannabinol
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[PDF File]Postmortem Fluid and Tissue Concentrations of THC, 11-OH ...
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inactive metabolite 11-nor-9-carboxy-tetrahydrocannabinol (THC-COOH). 4) THC is typically used for its euphoric effects.4) Non-desirable side effects include dizziness, dry mouth, (
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[PDF File]WHOLE BLOOD ANALYSIS OF Δ9 TETRAHYDROCANNABINOL …
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THC), and the inactive metabolite, 11-nor-9-carboxy-Δ9 -tetrahydrocannabinol (THC-COOH). THC affects mental processes, ranging from altered perception of time and distance to hallucinations, owing to the risk of use while driving. Peak THC effects are 20–30 minutes after use,
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[PDF File]The Significance of Blood & Urine Test Results
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Chesherxii summarised that the inactive metabolite THC acid, formed in the liver from metabolism of THC, appears after THC in blood, and if present when the a subsequent dose is smoked, higher concentrations would ensue. He commented: “analytical data that provides a value only for the metabolite can only be
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[PDF File]Blood & Urine Drug Testing for Cannabinoids 1. General
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2.6 Chesher9 summarised that.the inactive metabolite THC acid, formed in the liver from metabolism of THC, appears after THC in blood, and if present when the a subsequent dose is smoked, higher concentrations would ensue. Unmetabolised THC may be stored, and gradually released, from body fat for up to 28 days in chronic users.
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[PDF File]Analyte Name Trade Names DRE Category Pharmaceutical ...
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carboxy-THC Cannabis inactive metabolite of THC. carisoprodol Soma® CNS Depressants. Muscle Relaxant metabolizes to meprobamate. cathinone khat, qat CNS Stimulants. 1/3 potency of amphetamine
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[PDF File]Detection Times of Drugs of Abuse in Blood, Urine, and ...
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is analyzed, the molecule or metabolite that is looked for, the pH and concentration of the matrix (urine, oral fluid), and the interindividual variation in metabolic and renal clearance. In general, the detection time is longest in hair, followed by urine, sweat, oral fluid, and blood. In blood or plasma, most drugs of abuse can be detected at ...
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[PDF File]Delta-9-tetrahydrocannabinol (THC) serum concentrations ...
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pharmacokinetics of THC, the active metabolite 11-OH-THC and the inactive metabolite THC-COOH after smoking a combination of tobacco and cannabis containing high THC doses. Materials and methodsThis double-blind, placebo-controlled, four-way, cross-over study included 24 male non-daily cannabis users (two to nine joints per month).
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Inactive metabolite of thc