Klonopin half life

    • [PDF File]Opioid Tapering Flow Sheet - Oregon Pain Guidance

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      Drug Half-life (hrs) Dose Equivalent Chlordiazepoxide (Librium) 5–30 h 25mg Diazepam (Valium) 20–50 h 10mg Alprazolam (Xanax) 6–20 h 0.5mg Clonazepam (Klonopin) 18–39 h 0.5mg Lorazepam (Ativan) 10–20 h 1mg Oxazepam (Serax) 3–21 h 15mg Triazolam (Halcion) 1.6–5.5 h 0.5mg Phenobarbital (barbituate) 53 – 118 h 30 mg RAPID TAPER



    • BENZODIAZEPINES Equivalent Half-Life Dose Range Dose MAX Dose Geriatric ...

      KLONOPIN® 0.25. 1 – 4. 30 – 40 ... Avoid in elderly; long half-life. l. geriatric patients or in the presence of debilitating disease: 5 mg 2 to 4 times daily. 4. m. Anxiety: Max daily dose (MDD) 4 mg, Panic disorder, With or without agoraphobia: Range, 1 to 10 mg/d (mean, 5 to 6 mg/day) n. Not specified, start low & monitor


    • [PDF File]VALIUM TABLETS R Only WARNING: RISKS FROM CONCOMITANT USE WITH OPIOIDS ...

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      In children 3 - 8 years old the mean half-life of diazepam has been reported to be 18 hours. Newborns . In full term infants, elimination half-lives around 30 hours have been reported, with a longer average half-life of 54 hours reported in premature infants of 28 -34 weeks gestational age and 8 - 81 days post-partum. In both premature and


    • [PDF File]Safety Data Sheet KLONOPIN(R) Tablets (1.0 mg) - Genentech

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      repeated, because of the half-life of elimination of Clonazepam is much higher than this of Anexate SECTION 5: Firefighting measures 5.1. Extinguishing media Suitable extinguishing media - adapt extinguishing media to surrounding fire conditions - water spray jet, dry powder, foam, carbon dioxide Flash point (liquid) not applicable


    • [PDF File]KLONOPIN TABLETS (clonazepam) KLONOPIN WAFERS (clonazepam orally ...

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      Klonopin is also available as an orally disintegrating tablet containing 0.125 mg, 0.25 mg, 0.5 mg, 1 mg or 2 mg clonazepam. Each orally disintegrating tablet also contains ... The elimination half-life of clonazepam is typically 30 to 40 hours. Clonazepam pharmacokinetics are dose-independent throughout the dosing range. There is no evidence ...


    • [PDF File]TAPERING FLOWCHART - Virginia Premier

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      Clonazepam (Klonopin) 18–39 h 0.5mg Lorazepam (Ativan) 10–20 h 1mg Oxazepam (Serax) 3–21 h 15mg Triazolam (Halcion) 1.6–5.5 h 0.5mg ... Basic principle: Very long half life may necessitate a more protracted tapering process. Otherwise follow opioid principles. MED for Selected Opioids Opioid Approximate Equianalgesic


    • [PDF File]Drug Class Review Benzodiazepines in the Treatment of Anxiety Disorder

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      Clonazepam (Klonopin®) Oral 0.125 mg, 0.25 mg, 0.5 mg, 1 mg, 2 mg Treatment of petit mal variant (Lennox-Gastaut), akinetic and myoclonic seizures; petit mal (absence) seizures unresponsive to succimides; and panic disorder. Treatment of restless leg syndrome, neuralgia, multifocal tic disorder, parkinsonian dysarthria, bipolar


    • [PDF File]BENZODIAZEPINE EQUIVALENCY TABLE - University of North Carolina at ...

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      NAME Generic (Brand) Approx. Dose Equivalent to 10 mg Diazepam Available Tablet Strengths Duration of Action* Half-Life** (hours) Alprazolam (Xanax) 0.5-1 mg 0.25 mg, 0.5 mg, 1 mg, 2 mg, (3 mg - ER) Short 6-26 (ER: 10-16) Chlordiazepoxide 25 mg 5 mg, 10 mg, 25 mg Long 24-48 Clobazam (Onfi, Sympazan) 20 mg 10 mg, 20 mg Very Long >100 Clonazepam (Klonopin) 0.5 mg (0.125 mg, 0.25 mg - ODT), 0.5 ...


    • [PDF File]KLONOPIN TABLETS (clonazepam) - Food and Drug Administration

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      The elimination half-life of clonazepam is typically 30 to 40 hours. Clonazepam pharmacokinetics are dose-independent throughout the dosing range. There is no evidence that clonazepam induces its own metabolism or that ... Klonopin is contraindicated in patients with the following conditions: History of sensitivity to benzodiazepines


    • [PDF File]KLONOPIN TABLETS (clonazepam) Rx only - Food and Drug Administration

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      KLONOPIN TABLETS ... which can be life-threatening. To reduce the risk of withdrawal reactions, use a gradual taper to discontinue Klonopin or reduce the dosage (see DOSAGE AND ADMINISTRATION and WARNINGS). ... The elimination half-life of clonazepam is typically 30 to 40 hours. Clonazepam pharmacokinetics are dose-independent throughout the


    • [PDF File]SAFE PRESCRIBING BENZODIAZEPINES ACUTE TREATMENT ANXIETY & INSOMNIA

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      clonazepam (Klonopin®), are preferred in the short-term treatment of anxiety, whereas shorter acting agents, e.g., temazepam, are preferred to facilitate ... Half-life Parent (hours) Half-life Metabolite (hours) Comparative Oral Dose Long acting Chlordiazepoxide (Librium®) Int. (po) 2-4(po) 5-30 3-100 10mg


    • [PDF File]Benzodiazepine and Z-Drug Safety Guideline - Kaiser Permanente

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      • Short-acting (half-life less than 12 hours), such as midazolam and triazolam. • Intermediate-acting (half-life between 12 and 24 hours), such as alprazolam, lorazepam, and temazepam. • Long-acting (half-life greater than 24 hours), such as diazepam, clonazepam, clorazepate, chlordiazepoxide, and flurazepam.


    • Use of Benzodiazepines Among Elderly Patients

      Short-half-life benzodiazepines, such as oxazepam, alprazolam, and triazolam, are usually recommended for older adults, because these agents do not accumulate in the blood, are rapidly cleared from circulation, and offer greater dosage flexibility. Short-half-life benzodiazepines may be as-sociated with a clinically significant


    • [PDF File]Clinical Guidelines for Tapering Benzodiazepines - CBH

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      Medication Equivalent Dose Elimination Half-Life Chlordiazepoxide 10 mg >100hr Diazepam 5 mg >100hr Clonazepam 0.25-0.5 mg 20-50 hr Lorazepam 1 mg 10-20 hr Alprazolam 0.5 mg 12-15 hr Temazepam 10-20 mg 10-20 hr . 4 February 2019 Example 1 A tapering schedule like the one below can be shared with the individual to help everyone know what to ...


    • [PDF File]KLONOPIN TABLETS - PDR

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      The elimination half-life of clonazepam is typically 30 to 40 hours. Clonazepam pharmaco kinetics are dose-independent throughout the dosing range. ... Klonopin, and opioids may result in profound sedation, respiratory depression, coma, and death. Because of these risks, reserve concomitant prescribing of benzodiazepines and opioids


    • [PDF File]Benzodiazepine Tapering Flow Sheet - Nebraska Department of Health ...

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      Clonazepam (Klonopin) Oxazepam (Se rak) Triazolam (Halcion) Phenobarbital (ba rbituate) Half-life (hrs) 5—30 h 20-50 h 6—20 h 18-39 h 10-20 h 3—21 h 1.6—5.5h 53-118 h . Title Nebraska Pain Management Guidance Document v3.2 Author: areynol Created Date:


    • [PDF File]Effective Treatments for PTSD: Helping Patients Taper from Benzodiazepines

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      Half-life Chlordiazepoxide 10 mg >100hr Diazepam 5 mg >100hr Clonazepam 0.25-0.5 mg 20-50 hr Lorazepam 1 mg 10-20 hr Alprazolam 0.5 mg 12-15 hr Temazepam 10-20 mg 10-20 hr Benzodiazepine Taper: • Switching to a longer acting benzodiazepine may be considered if clinically appropriate. These are suggestions


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