List of ras inhibitor drugs
[DOC File]“EVALUATION OF ANTIDIABETIC ACTIVITY OF HELICTERES
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Vemurafenib is an inhibitor of some mutated forms of BRAF kinase, including V600E. ... The classical MAPK pathway consists of RAS, RAF, MEK and ERK where RAS triggers the formation of the RAF/MEK/ERK kinase complex. ... co-administered drugs that are CYP450 or P-glycoprotein inhibitors/inducers are unlikely to alter the plasma kinetics of ...
Abstract
Most Australian and international clinical guidelines recommend an individualised approach to the treatment of type 2 diabetes and the optimal HbA 1c target with regards to each patient. The balance is between optimal management of the disease and the prevention of microvascular events, and …
[DOCX File]Australian Public Assessment Report for Vemurafenib
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This report can be printed for all drugs in the local drug file that have Local Possible Dosages defined or only the drugs that have Local Possible Dosages defined with missing data in either the NUMERIC DOSE sub-field (#5) of the LOCAL POSSIBLE DOSAGES multiple (#904) in DRUG file (#50) or DOSE UNIT sub-field (#4) of the LOCAL POSSIBLE DOSAGES ...
Vasodilators Side Effects, List of Names (Prescription, Natural, OTC)
Expert Opin Investig Drugs 2013; 22 ($): 463-486. Cefalu, WT, Leiter LA, Niskanen L, et al. Efficacy and safety of canagliflozin, a sodium glucose co-transporter 2 inhibitor, compared with glimepiride in patients with type 2 diabetes on background metformin. American Diabetes Association's 72nd Scientific Sessions June 8 - 12, 2012. Abstract 38-LB
Sunesis Pharmaceuticals, Inc.
HAART (Highly active antiretroviral therapy) consists of three or more drugs, often two types of nucleoside analogs and one protease inhibitor. In many cases HAART can lower the viral load to undetectable levels and has been the major factor in reducing the mortality rate for AIDS in recent years.
[DOCX File]Home | Molecular Cancer Therapeutics
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Raf kinase is an enzyme in the Ras pathway, a signaling pathway important to cell proliferation. The goal of this program is to develop Raf kinase inhibitors with improved pharmaceutical properties as compared to other Raf kinase inhibitors in development. ... We are also working on the identification and optimization of kinase inhibitor drugs ...
[DOC File]National PBM Drug Monograph
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RAS. aberrations. More specifically, we defined “matched-direct” if at least one drug directly impacted the gene product of the molecular alteration or a differentially expressed protein [e.g. an EGFR inhibitor in a patient with an EGFR alteration (direct effect on the molecular aberration) or hormonal manipulation in patients with over ...
[DOC File]Questions for Practice Test 1 (RAS)
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ACE Inhibitor drugs inhibit competitively the activity of ACE (also termed kininase II) to prevent formation of the active octapeptide, angiotensin II, from the inactive decapeptide, angiotensin I. This occurs in blood and tissues including kidney, heart, blood vessels, adrenal gland and brain.
[DOC File]Department of Veterans Affairs Pharmacy Data Management ...
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Natural products and drugs under investigation with possible anti-cancer metabolism activity are also discussed. ... like PI3K, AKT, RAS, c-Myc, promote glycolysis while tumor suppressors tend to ...
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