Liver and fat metabolism

    • Gut and liver fat metabolism in depancreatized dogs: effects of ...

      ing fat levels are a defining feature of poor metabolic control in diabetes. Splanchnic adipose tissue is a source of free fatty acids (FFA), and the liver is a key site of FFA utilization and the sole source of ketones. Despite the role of splanchnic tissues in fat metabolism, little is known about how these


    • An Integrated Understanding of the Rapid Metabolic Benefits of a ... - Cell

      on Liver Fat Earlier studies designed to reduce hepatic steatosis in subjects with NAFLD have usually combined carbohydrate restriction with calorie reduction and did not separate out the effect of amplified weight loss (Browning et al., 2006, 2011). To investi-gate how liver fat metabolism is affected by reduced carbo-


    • [PDF File]Influence of dietary macronutrients on liver fat accumulation and ...

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      Influence of dietary macronutrients on liver fat accumulation and metabolism Siôn A Parry, Leanne Hodson to cite: Parry SA, Hodson L. J Investig Med 2017;65:1102–1115. Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK correspondence to Dr Leanne Hodson, Radcliffe Department of


    • TM6SF2 is a regulator of liver fat metabolism influencing triglyceride ...

      in liver fat metabolism by influencing secretion of TG-rich lipo-proteins (TRLs) and hepatic lipid droplet content. Significance Genome-wide association studies have uncovered a genetic locus in chromosome 19 associated with the plasma triglyceride (TG) concentration, a risk factor for coronary heart disease. The


    • Response of liver metabolic pathways to ketogenic diet and ... - LSU

      tions. Therefore, we tested hepatic substrate metabolism path-ways in lean, healthy mice that underwent an ExTr regimen while being fed a KD. Importantly, although KD consistently have a high fat content and very low/no carbohydrate, protein content often varies. The majority of literature testing effects



    • [PDF File]New insights into sympathetic regulation of glucose and fat metabolism

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      the sympathetic nervous system on glucose and fat metabolism can therefore prevail over those of the parasympathetic nervous system. Sympathetic effects on glucose and fat metabolism Effects of the sympathetic nervous system on hepatic glucose production. Glucose is a major energy source of cell activity and is produced mainly by the liver.


    • Capsaicin suppresses liver fat accumulation in high-fat diet-induced ...

      metabolism Introduction Steatosis (fatty liver) is an accumulation of fat in the liver. When this progresses to become associated with inflam-mation, it is known as steatohepatitis. Fatty liver disease is divided into alcohol-related and NAFLD. The preva-lence of NAFLD, a frequent chronic liver condition has dramatically increased over the ...



    • [PDF File]LIPID AND LIPOPROTEIN METABOLISM IN LIVER DISEASE - Endotext

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      FFA are then delivered via the circulation to the liver and may overwhelm the liver’s capacity to oxidize or export lipids, contributing to the development of steatosis. The fatty acid translocase FAT/CD36 mediates uptake of FFA into the liver and is upregulated in human and experimental NAFLD, which may contribute to steatosis (6,7,8).


    • [PDF File]Metabolic traits affecting the relationship between liver fat and ...

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      Lipid metabolism is dysregulated in fatty liver disease as increased liver fat results in hepatic overproduction of VLDL particles and dysregulated clearance of lipoproteins from the circulation [ 1, 23]. Lipid panel was significantly asso- ... (IQR) liver fat and IPFD was 5.7 (3.1–12.0)% and 8.7 (7.0– ...


    • [PDF File]Correlation between changes in liver fat content and ... - Akero

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      treatment with EFX significantly reduced liver fat content and improved markers of liver injury, fibrosis, and lipid and glucose metabolism while demonstrating an acceptable safety and tolerability profile1. As a regulator of whole-body metabolism, FGF21 coordinates whole body metabolism between liver, adipose tissue, and other organs that


    • [PDF File]The Mighty Liver (pg 1 of 5) - Straight A Nursing

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      Carbohydrate metabolism HypoG may develop d/t impaired glycogenolysis and gluconeogenesis Stores glycogen and synthesizes glucose from AA, lactic acid and glycol Abnormal glucose tolerance curve may occur d/t impaired uptake and release of glucose by the liver Fat metabolism impaired synthesis of lipoproteins, altered cholesterol levels


    • Astragaloside IV ameliorates fat metabolism in the liver of ageing mice ...

      The liver is the central organ for TG and fatty acid metabolism. Abnormal lipid metabolism is closely related to the abnormal liver functions. The main feature of a common disease in the liver, such as non-alcoholic fatty liver disease (NAFLD), is resulted from the abnormal TG accumulation in the liver. Increasing lines of evidence


    • [PDF File]The influence of dietary fatty acids on liver fat content and metabolism

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      The influence of dietary fatty acids on liver fat content and metabolism Leanne Hodson1* , Fredrik Rosqvist1,2 and Siôn A Parry1 1Oxford Centre for Diabetes, Endocrinology and Metabolism, ... liver fat content to a greater extent when compared with diets enriched in unsaturated fats. Liver fat: Dietary: SFA: PUFA


    • Liver lipid metabolism - Wiley Online Library

      the liver and the adipose tissue. Fatty acids synthe-sized in the liver are exported through lipoprotein production, and thus provide an energy source and structural components for membrane building. In adipose tissue, De novo synthesis of fatty acids directly contributes to in situ fat deposition and long-term energy storage.


    • Lipid Metabolism and Liver Inflammation. I. Hepatic fatty acid uptake ...

      Lipid Metabolism and Liver Inflammation. I. Hepatic fatty acid uptake: possible role in steatosis Michael W. Bradbury Department of Biochemistry, Lake Erie College of Osteopathic Medicine, Erie, Pennsylvania Bradbury, Michael W. Lipid Metabolism and Liver Inflamma-tion. I. Hepatic fatty acid uptake: possible role in steatosis. Am J


    • [PDF File]Fat Metabolism - Ohio State University

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      THE ACTION OF LIVER CELLS ON FAT. The normal liver contains 5% lipids, about evenly distributed as phospho-lipid and neutral fat. In 1909 Leathes and Wedell (6) showed that when cats are fed on certain fats the iodine number of the liver fatty acids is greater than that of the fatty acids of the food. Leathes suggested, on the basis of these ...


    • [PDF File]LIVER AND METABOLISM - ResearchGate

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      major functions of the liver are carbohydrate, protein and fat metabolism, detoxification, secretion of bile and storage of vitamin. Thus, to maintain a healthy liver is a compelling


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