Loop diuretics vs thiazide

    • [PDF File] Pediatric Pharmacotherapy - University of Virginia School of …

      http://5y1.org/file/21171/pediatric-pharmacotherapy-university-of-virginia-school-of.pdf

      Loop Diuretics Loop diuretics are the most potent of the available diuretics (4). These agents work by blocking the Na+ -K+ -2Cl- transporter in the ascending loop of Henle, inhibiting reabsorption of these ions. Because reabsorption of approximately 25% of the filtered sodium occurs in this tubular segment, use of loop diuretics

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    • [PDF File] Thiazide diuretics and risk of knee replacement surgery …

      http://5y1.org/file/21171/thiazide-diuretics-and-risk-of-knee-replacement-surgery.pdf

      study to examine the relation of thiazide diuretic initiation vs loop diuretic initiation to the risk of KR over 5 years. Results: Among thiazide and loop diuretic initiators (n ¼ 3,488 for each group; mean age: 73 years; female ratio: 59%), 359 (28.6/1,000 person-years) and 283 (24.1/1,000 person-years) KRs occurred during

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    • [PDF File] THIAZIDE DIURETICS - Norfolk and Norwich University …

      http://5y1.org/file/21171/thiazide-diuretics-norfolk-and-norwich-university.pdf

      What are thiazide diuretics? Diuretics are medicines sometimes called “water pills”. Thiazides are a type of diuretic used to treat high blood pressure and also heart failure. Names BENDROFLUMETHIAZIDE is a thiazide diuretic. CHLORTALIDONE (Hylaton®), INDAPAMIDE (Natrilix®) and XIPAMIDE (Diurexan®) are related to thiazide diuretics and

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    • [PDF File] How do we maximize diuresis in acute decompensated heart …

      http://5y1.org/file/21171/how-do-we-maximize-diuresis-in-acute-decompensated-heart.pdf

      A: in patients with acute decompensated heart failure (ADHF), the initial diuretic regimen should maximize intravenous loop diuretics based on urine output or spot urine sodium. Combina-tion therapy can be used if diuretic resistance occurs. ADHF accounts for more than 1 million hospi-talizations per year in the United States, and inad-equate ...

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    • [PDF File] DRUG CLASSES THIAZIDE AND THIAZIDE-LIKE DIURETICS

      http://5y1.org/file/21171/drug-classes-thiazide-and-thiazide-like-diuretics.pdf

      Thiazide-like Chlortalidone Indapamide Mechanism of action Thiazide and thiazide-like diuretics act on the nephron mainly at the proximal part of the distal tubule. Sodium excretion and urine volume are increased by interference with transfer across cell membranes. The result is a reduction in blood volume. However,

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    • [PDF File] Diuretic Treatment in Patients with Heart Failure: Current

      http://5y1.org/file/21171/diuretic-treatment-in-patients-with-heart-failure-current.pdf

      diuresis. Resistance to the actions of escalating doses of loop diuretics is common,[4 , 5] which can often be overcome by adding a dierent class of diuretic agent. There are many possible adjuncts to loop diuretic therapy, including thiazide diuretics, acetazolamide, sodium-glucose co-transporter 2 inhibitors (SGLT2I), arginine vasopressin

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    • [PDF File] Dapagliflozin vs. metolazone in heart failure resistant to loop …

      http://5y1.org/file/21171/dapagliflozin-vs-metolazone-in-heart-failure-resistant-to-loop.pdf

      To examine the decongestive effect of the sodium-glucose cotransporter 2 inhibitor dapagliflozin compared to the thiazide- like diuretic metolazone in patients hospitalized for heart failure and resistant to treatment with intravenous furosemide. ... ume, relative to interstitial fluid volume, compared to loop diuretics, Dapagliflozin vs ...

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    • [PDF File] Combination of Loop Diuretics With Thiazide-Type …

      http://5y1.org/file/21171/combination-of-loop-diuretics-with-thiazide-type.pdf

      doses of loop diuretics. One approach to overcome loop diuretic resistance is the addition of a thiazide-type di-uretic to produce diuretic synergy via “sequential nephron blockade,” first described more than 40 years ago. Although potentially able to induce diuresis in patients otherwise resistant to high doses of loop diuretics, this

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    • [PDF File] Thiazide Effects and Adverse Effects - AHA/ASA Journals

      http://5y1.org/file/21171/thiazide-effects-and-adverse-effects-aha-asa-journals.pdf

      NCC Deficiency and Essential Hypertension. A final insight into effects of thiazide diuretics may come from novel genetic approaches. GS and BS are autosomal, recessive, salt-wasting disorders that reduce blood pressure by mutations in salt transport genes along the loop of Henle and DCT.

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    • [PDF File] THIAZIDE AND THIAZIDE-LIKE DIURETICS

      http://5y1.org/file/21171/thiazide-and-thiazide-like-diuretics.pdf

      PDF-1.5 %µµµµ 1 0 obj >>> endobj 2 0 obj > endobj 3 0 obj >/ExtGState >/Font >/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 4 0 R ...

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    • [PDF File] Thiazide-Type Diuretics: Ongoing Considerations on …

      http://5y1.org/file/21171/thiazide-type-diuretics-ongoing-considerations-on.pdf

      both loop diuretics and thiazide-type diuretics in respect to the management of hypertension. In this regard, loop diuretic effect on BP is a function of at least two processes: 1) the manner in which volume removal occurs; and 2) the ability of these compounds to independently decrease TPR. It has been observed that small doses of …

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    • [PDF File] Loop and thiazide diuretic use and risk of chronic kidney …

      http://5y1.org/file/21171/loop-and-thiazide-diuretic-use-and-risk-of-chronic-kidney.pdf

      who initiated loop diuretics (4.92 (95% CI: 4.34 to 5.59) vs 0.30 (95% CI: 0.28 to 0.33)), but not in those who initiated thiazide diuretics (0.30 (95% CI: 0.20 to 0.46) vs 0.43 (95% CI: 0.40 to 0.46)). However, neither initiation of diuretics or type of diuretic were significantly associated with CKD progression or ESRD after accounting for ...

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    • [PDF File] The Silent Epidemic of Thiazide-Induced Hyponatremia

      http://5y1.org/file/21171/the-silent-epidemic-of-thiazide-induced-hyponatremia.pdf

      THIAzIDE DIURETICS VS OTHER DIURETICS Most reported cases of diuretic-induced hypona-tremia are associated with a thiazide diuretic, although cases are also reported with loop diuret-ics and with spironolactone.3,7 Underlying conges-tive heart failure, for which loop diuretics are the usual diuretic prescribed, is itself a risk factor for

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    • [PDF File] Thiazide and Loop Diuretics - Wiley Online Library

      http://5y1.org/file/21171/thiazide-and-loop-diuretics-wiley-online-library.pdf

      Diuretic-related biochemical side effects are dose-dependent as well as more common and of greater intensity with loop diuretics. As practice patterns shifted to a low-dose strategy for thiazide-type diuretics, the frequency of metabolically negative side effects diminished. Thus, hypokalemia, hypomagnese-mia, and glucose intolerance are much ...

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    • [PDF File] Thiazide diuretics: their properties and use in hypertension

      http://5y1.org/file/21171/thiazide-diuretics-their-properties-and-use-in-hypertension.pdf

      Table 1. Adverse effects of thiazide and thiazide-like diuretics. hypertension is complicated by chronic renal impairment (serum creatinine >150mmol per litre; eGFR <45ml per minute per 1.73m2), thiazide diuretics are usu-ally ineffective; a loop diuretic, often at high doses, can be substituted. Thiazide and thiazide-like diuretics are often ...

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    • [PDF File] Risk vs Benefits of Thiazides in Clinical Use: Need for a Holistic …

      http://5y1.org/file/21171/risk-vs-benefits-of-thiazides-in-clinical-use-need-for-a-holistic.pdf

      tions like loop diuretics.4 Significantly greater use of loop diuretics indicates presence of renal insufficiency in the thiazide group and hence, this causation is erroneous. Nonsteroidal anti-inflammatory drugs: Inhibition of renal prostaglandin synthesis can cause electrolyte and acid-base disturbances (sodium retention, hyponatremia,

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    • [PDF File] Diuretic Treatment in Patients with Heart Failure: Current

      http://5y1.org/file/21171/diuretic-treatment-in-patients-with-heart-failure-current.pdf

      pared to placebo [25– 28]. Loop diuretics led to a larger and quicker diuresis than either acetazolamide, or spironolactone alone, and had an additive diuretic eect when given in com-bination with either agent (Table 1) [16, 29]. Compared to thiazide diuretics, loop diuretics tended to induce a greater diuresis and greater symptomatic improve-

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    • [PDF File] Rationale and Design of the “Safety and Efficacy of the …

      http://5y1.org/file/21171/rationale-and-design-of-the-safety-and-efficacy-of-the.pdf

      Fluid overload refractory to loop diuretics in HF results from an interaction between the pathophysiology of sodium retention in HF and the renal response to diuretic therapy.9 With the use of loop diuretics, the “postdiuretic effect” (an increase in sodium retention after the loop diuretic has worn off) can appear in the short term.

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    • [PDF File] Therapeutic roles of thiazides and loop diuretics in blood …

      http://5y1.org/file/21171/therapeutic-roles-of-thiazides-and-loop-diuretics-in-blood.pdf

      pressure or CKD have stated that evidence for benefits of thiazide diuretics is not conclusive yet in patients with advanced CKD, although loop diuretics are often effective for volume control at lower glomerular filtration rate. Recently, evidence for diuretics as effective blood pressure lowering agents in patients with advanced CKD is ...

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    • [PDF File] Diuretic-induced Severe Hyponatremia - CHEST

      http://5y1.org/file/21171/diuretic-induced-severe-hyponatremia-chest.pdf

      more than loop diuretics. Various mechanisms have been postulated to explain the phenomenon of diu-retic-induced hyponatremia in general and the differ-ence between the loop diuretics and thiazides in particular. The salient mechanism for thiazide-in-duced hyponatremia is related to the reduction in the renal free water clearance.

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    • [PDF File] Loop Diuretics in the Treatment of Hypertension - Springer

      http://5y1.org/file/21171/loop-diuretics-in-the-treatment-of-hypertension-springer.pdf

      Pharmacokinetics. Pharmacokinetic properties of the loop diuretics are summa-rized in Table 1. As shown, the bioavailability of furosemide is lower and more variable than that of torsemide and bumeta-nide [22]. Another important difference among the loop. diuretics is the longer half-life of torsemide [22].

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    • [PDF File] A review of the prescribing trend of thiazide‐type and …

      http://5y1.org/file/21171/a-review-of-the-prescribing-trend-of-thiazide‐type-and.pdf

      cokinetic and pharmacodynamic profile (Table S1). Thiazide-type diuretics include bendroflumethiazide (BDTZ) and hydrochlorothiazide (HCTZ) while other drugs with a similar pharmacological action but a different chemical structure, such as indapamide (INDA) and chlorthalidone (CLTD), are termed thiazide-like diuretics. Thiazide-type

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