Metabolism of hydrocodone
[DOC File]Equianalgesic Chart (Changes in italics)
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Hydrocodone (Hycodan, Vicodin, Lortab, and Lorcet): Is a semi synthetic opiate that provides significant pain relief. As an opioid, it will not be detected in the common 5 or 10 drug screen panel unless it is specially added as with Elssi drug testing. Metabolite in urine as hydrocodone, then to hydromorphone and codeine.
[DOC File]National PBM Monograph Template Rev20091005
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Similarly, hydrocodone is metabolized to hydromorphone, so that both may legitimately be found in the urine of a patient who is being prescribed hydrocodone (Vicodin, Lorcet, etc. (Gourlay et al, 2002; Heit & Gourlay, 2004). But again, the reverse is not true; a patient prescribed hydromorphone (Dilaudid) should not have hydrocodone in the urine.
[DOCX File]jwhitesell.ucsd.edu
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Liver metabolism Flurazepam Benzodiazepine (↑ Frequency of GABA-A Receptors) Hypnotic (Inpatient – Long acting) OD & OSA. Daytime sedation. Tolerance, Pregnant, Elderly Alcohol. Sedatives. Hypnotics Dose Dependent Effects-Not CNS Depressants. Require GABA to hyperpolarize; Lipophilic. Active Metabolite & Longest t1/2 Temazepam (Restoril ...
[DOC File]DRUGS OF ABUSE REFERENCE GUIDE
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type of opiates offer the excuse of eating a pastry with poppy seeds after a quick search online, without any understanding of the metabolism of the compounds in the body. Fortunately, studies have found that heroin is metabolized in the body into morphine, and codeine is metabolized into morphine and hydrocodone [6].
[DOC File]Organism - University of Kentucky
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The metabolism of a single dose results in a 32-hour urine that contains about 19% as the parent drug (MDEA), 28% as MDA, and 32% as HMEA, with trace amounts of at least eight other metabolites. The anticipated time to a negative result after the last use of MDEA is approximately 1 to 2 days.
New Drug Review
There are two principal situations in which ultra-rapid metabolism of codeine to morphine may be of concern: where a child is an ultra-rapid metaboliser of codeine and ingests a codeine-containing product, or where the mother of a child is an ultra-rapid metaboliser of codeine and the resulting metabolite (morphine) is ingested by an infant through breast milk.
Excretion Profile of Hydrocodone, Hydromorphone and Norhydroc…
Morphine undergoes glucuronidation to morphine-3-glucuronide (M3G, approximately 50%) and morphine-6-glucuronide (M6G, approximately 5 to 15%). Minor pathways of metabolism include sulfation to morphine-3-etheral sulfate and demethylation. M6G is an active metabolite, but has poor ability to cross the blood-brain barrier.1
[DOC File]Jennifer P. Schneider M.D., PH.D.
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Appropriate monitoring is required. Refer to Nursing Policies 8.021 and 8.025. Hydrocodone with acetaminophen** (Lortab®, Vicodin®) PO 5 - 10 mg hydrocodone q 4 - 6 hr 60 min 2 hr 4 - 6 hr Liver 4 hr Available at UIHC as: ( Tablet with 5 mg hydrocodone and 500 mg acetaminophen. ( Elixir with 2.5 mg hydrocodone and 167 mg acetaminophen
[DOCX File]Codeine use in children and ultra-rapid metabolisers
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Oral bioavailability ranges from 60 – 87%, which is higher than other oral opioids due to decreased pre-systemic and/or first-pass metabolism.2. Metabolism occurs via multiple metabolic pathways including CYP3A4 and CYP2D6, producing metabolites which are ultimately glucuronidated.
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