Metabolites of hydrocodone in urine
[DOC File]Prepared By - Beckman Coulter
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The Emit® II Plus Opiate Assay detects morphine, morphine-3-glucuronide (the major metabolites in heroin), and codeine in human urine. The following table lists the compounds this assay is designed to detect and the levels at which the compounds have been found to give a response approximately equivalent to the Emit® Calibrator/Control Level ...
[DOC File]Medical Review Officer Manual - SAMHSA
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minor metabolites (e.g., normorphine, morphine-3-ethereal sulfate, morphine-3,6-diglucuronide) Morphine and its metabolites can be detected in urine up to about 4 days after morphine use. Morphine is not metabolized to codeine. Codeine (methylmorphine) is also rapidly absorbed and is excreted as: unchanged codeine, morphine . glucuronide conjugates
[DOC File]United States Navy
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Screen Target DoD Limit in urine (ng/mL) GC/MS Target DoD Limit in urine (ng/mL) Detection Window* Marijuana** THC cannabinoid metabolites 50 11-nor-Δ-9-THC-carboxylic acid 15 1-3 days after use Cocaine Benzoylecgonine 150 Benzoylecgonine (BZE) 100 1-3 days after use Amphetamines*** Methamphetamine 500 d-amphetamine. d-methamphetamine 100
[DOCX File]Australian public assessment report for Milnacipran ...
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There was no evidence of accumulation after repeat exposure. The major degradant F1612 showed similar kinetics. Metabolism of milnacipran was limited, with three metabolites detected in plasma and urine; desethyl milnacipran and D and L carbamoyl O-glucuronides. There was a similar metabolite profile in plasma and urine of animals and humans.
New Drug Review - Massachusetts
The primary route of excretion for hydrocodone and its metabolites is via renal excretion. In healthy subjects, approximately 6.5% of an administered dose of hydrocodone is excreted into the urine unchanged. This is reduced to 5%, 4.8% and 2.3% in subjects with mild, moderate and severe renal impairment, respectively.
[DOC File]Assessment and Drug Testing Practice Guidelines
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Detection: Timing is a critical factor in drug and alcohol testing. The amount of time a drug remains in the body is dependent on a variety of factors including the amount of drug taken and the metabolism of the individual. A negative test indicates that no drugs or metabolites were detected in the sample tested above the cutoff level.
[DOC File]DRUGS OF ABUSE REFERENCE GUIDE - ELSSI Drug Testing
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Hydrocodone (Hycodan, Vicodin, Lortab, and Lorcet): Is a semi synthetic opiate that provides significant pain relief. As an opioid, it will not be detected in the common 5 or 10 drug screen panel unless it is specially added as with Elssi drug testing. Metabolite in urine as hydrocodone, …
New Drug Review, Xtampza ER Drug Monograph
The total plasma clearance in adults was 84 L/hr. Amounts of oxycodone and its metabolites have been measured in the urine as follows: free and conjugated oxycodone 8.9%, free noroxycodone 23%, free and conjugated noroxymorphone 14%, free oxymorphone < 1%, conjugated oxymorphone 10% and other reduced free and conjugated metabolites up to 18%.1
[DOC File]DESCRIPTION - vitro diagnostic
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Hydrocodone bitartrate and acetaminophen is supplied in tablet form for oral administration. ... and subsequent renal excretion of metabolites. Approximately 85% of an oral dose appears in the urine within 24 hours of administration, most as the glucuronide conjugate, with small amounts of other conjugates and unchanged drug. ...
[DOC File]Pharmacy Benefits Management Services Home
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Acetaminophen metabolites are excreted primarily in the urine. The half-life may be prolonged in severe renal insufficiency (2-5.3 hours) or following toxic doses.19 . Table 1 Pharmacokinetic Parameters of Various Dosage Forms of Acetaminophen. Parameter Acetaminophen IV Acetaminophen Oral Acetaminophen Rectal Metabolism Liver:* Glucuronidation
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