Methadone iv vs po
[PDF File] Pain Management & Dosing Guide™ - University of Florida
http://5y1.org/file/22228/pain-management-dosing-guide-university-of-florida.pdf
1 g IV q 6 h Max: 4 g/day or 650 mg q 4 h prn pain. <50 kg. 15 mg/kg IV q 6 h or 12.5 mg/kg IV q 4 h prn pain Max: 75 mg/ kg/day. 100-200 mg PO daily to q ≥ 2 yo to adult Celecoxib 12 h 10-25 kg: 50 mg (Celebrex®) PO BID; > 25 kg: Max: 400 mg/ 100 mg BID day. 400-800 mg 10 mg/kg PO q 6 to 8 h Ibuprofen PO q 6 to 8 h (Motrin®) Max: 3200 mg ...
[PDF File] Opioid Conversion Table - BC Renal
http://5y1.org/file/22228/opioid-conversion-table-bc-renal.pdf
5 Percocet contains acetaminophen 325 mg + oxycodone 5 mg per tab. To make 20 mg of oxycodone, four Percocet tablets q4h are required, which contain toxic amount of acetaminophen. The maximum recommended acetaminophen dose is 4000 mg or 12 x Percocet tabs per 24 hrs. 6 Methadone has a prolonged and variable half-life; regular …
[PDF File] Switching Ratio from Parenteral to Oral Methadone 1:1.2 Is …
http://5y1.org/file/22228/switching-ratio-from-parenteral-to-oral-methadone-1-1-2-is.pdf
Methadone side effects were observed in 12 patients in ratio 1:2 (mainly neurotoxicity symptoms) versus 2 in ratio 1:1.2 ( p<0.005). Conclusion: Ratio 1:1.2 when changing from parenteral to oral methadone resulted in lower toxicity and no difference in analgesia. More conservative dose adjustment during methadone route change should be con-sidered.
[PDF File] Oral Methadone Dosing Recommendations for the …
http://5y1.org/file/22228/oral-methadone-dosing-recommendations-for-the.pdf
A proposed safe and conservative approach is a 1:3 methadone to morphine ratio (10mg methadone/day = 30mg oral morphine/day).3 However, literature suggests patients may end up on as high as 1:4.7 methadone to morphine ratio …
[PDF File] Opioid PCA Conversion to Oral Opioid Regimen - Houston …
http://5y1.org/file/22228/opioid-pca-conversion-to-oral-opioid-regimen-houston.pdf
Convert total IV opioid dose to oral opioid of choice 3. If converting from one opioid to another, reduce total daily dose by 20-50% to account for incomplete cross-tolerance ... 6.2 mg IV hydromorphone x 20 = 124 mg PO morphine STEP 2b Convert total oral morphine dose to desired oral opioid Per dose conversion chart: Divide by a …
[PDF File] Opioid conversion ratios - Safer Care Victoria
http://5y1.org/file/22228/opioid-conversion-ratios-safer-care-victoria.pdf
4. Oral methadone to subcutaneous methadone – same drug to same drug 8 5. Determining oral morphine breakthrough dose when on transdermal fentanyl 9 6. Subcutaneous fentanyl to transdermal fentanyl – same drug to same drug 9 7. Determining transmucosal fentanyl breathrough pain dose 9 8. Subcutaneous morphine to other …
[PDF File] Oral and intravenous oxymorphone: Relative potency …
http://5y1.org/file/22228/oral-and-intravenous-oxymorphone-relative-potency.pdf
Indicates that oral oxymorphone is more potent than all listed comparators: twice as potent as oral oxycodone, hydrocodone, methadone; three times as potent as oral morphine. 3.. Endo ...
[PDF File] Methadone – safe and effective use for chronic pain
http://5y1.org/file/22228/methadone-safe-and-effective-use-for-chronic-pain.pdf
thadone. Step 1. Current opioid use: morphine 90 mg per dayStep 2. Not requiredStep 3. Methadone dose: Divide t. e total daily morphine dose by the appropriate eq. 4 = 22.5 mg methad. ne per day given as 7.5 mg three times daily or rounded down to10 mg t.
[PDF File] METHADONE HYDROCHLORIDE INJECTION, USP 200 mg/20 …
http://5y1.org/file/22228/methadone-hydrochloride-injection-usp-200-mg-20.pdf
methadone hydrochloride, equivalent to 8.95 mg of methadone free base. Methadone hydrochloride is a white, crystalline material that is water-soluble. Methadone hydrochloride is chemically described as 6-(dimethylamino)-4,4-diphenyl-3-hepatanone hydrochloride. Its molecular formula is C 21H 27NO•HCl and it has a molecular weight of 345.91.
[PDF File] What to Consider when Choosing an Opioid for Use in a …
http://5y1.org/file/22228/what-to-consider-when-choosing-an-opioid-for-use-in-a.pdf
Dog: 0.1–0.2 IM or IV Cat: 0.1 IM or IV Dog and cat: 0.1 IM, IV Methadone 10 mg/mL DEA Class II Similar to morphine but no histamine release and little to no vomiting; is also an N-methyl-D-aspartate antagonist but clinical significance is not known Dog and cat: 0.2–0.4 IV; 0.2–0.6 (up to 1.0 in dogs) IM Cat: 0.6 OTM Dog and cat: 0.4 IM ...
[PDF File] Methadone and QTc Prolongation - University of …
http://5y1.org/file/22228/methadone-and-qtc-prolongation-university-of.pdf
QTcprolongation with IV methadone compared to oral due to the preservativechlorobutanolwith an average increase of 42 msec from baseline. 2,3. A prospectivetrial of 100 cancer patients starting methadone therapy found that although baselineQTc prolongation was common, increases to >500 msec were rare. 4. Noneof …
[PDF File] Opioid Analgesics - Stanford Medicine
http://5y1.org/file/22228/opioid-analgesics-stanford-medicine.pdf
IV, oral, buccal, sublingual, intranasal, subQ, intramuscular, and neuraxial ... ›Converting from IV to PO, dosage increased by approximately 4x ›Peak effect at 15-30 minutes when given intravenous; duration 2-3 ... Methadone Synthetic opioid first tested as a treatment for heroin addiction in 1964
[PDF File] Demystifying Opioid Conversion Calculations: A Guide for
http://5y1.org/file/22228/demystifying-opioid-conversion-calculations-a-guide-for.pdf
converting from parenteral PCA therapy to. oral or transdermal opioid therapy, 212. dosage escalation, 104–105, 107. dosage reduction, 110. epidural catheter pulled out, 215. methadone in opioid-naïve patient, 154–155. PCA, 199–200. PCA by proxy, 200–201. PCA continuous infusion dosing, 202.
[PDF File] Pediatric Pain Pocket Reference (Recommended starting …
http://5y1.org/file/22228/pediatric-pain-pocket-reference-recommended-starting.pdf
IV: 0.01mg/kg q6h As needed or ATC for agitation/ anxiety, skeletal muscle spasm. *Helpful as adjunct to opioids for anxiety, myoclonus, nausea/vomiting Diazepam PO: 0.1mg/kg q8h As needed for anxiety, skeletal muscle spasm. Typical starting dose 1-5mg PO q8h. Max 10mg PO q8h Gabapentin PO: 5-40mg/kg/day in 3 divided doses (children ≥3 years old)
[PDF File] Inpatient Management of Opioid Use Disorder: Methadone
http://5y1.org/file/22228/inpatient-management-of-opioid-use-disorder-methadone.pdf
4. Methadone dosing considerations: Peak concentration of methadone is ~3.5 hours after dose received and onset of action is 30 minutes to 1 hour after dose is received, so provider or RN per provider order must evaluate for sedation and withdrawal symptoms via COWS assessment 30 minutes and 4 hours after each dose.
[PDF File] Adult Opioid Reference Guide - UI Health Care
http://5y1.org/file/22228/adult-opioid-reference-guide-ui-health-care.pdf
Methadone PO 2.5 mg 1 to 4 times daily 30 - 240 min 2 - 4 hr 4 - 24 hr Liver 24 hr* Used in chronic pain. Dosing adjustments should be made every 5 days. More frequent dose increases can result in accumulation and respiratory depression. Monitor for QT interval prolongation in patients with heart disease Morphine MS Contin® PO IM IV SQ PO-SR
[PDF File] Conversion of Opioid Medicines Dosages
http://5y1.org/file/22228/conversion-of-opioid-medicines-dosages.pdf
Total daily morphine dose =. Divide total by two =. Prescribe as morphine MR. 20 mg x 6 doses = 120 mg daily 120 mg divided by 2 = 60 mg = 60 mg twice daily. Ensure also that an appropriate dose of immediate release opioid is prescribed “as required (prn)” for breakthrough pain. This should be the 4 hourly equivalent of the total daily dose.
[PDF File] Onset, Peak, and Duration of Common Pain Medications …
http://5y1.org/file/22228/onset-peak-and-duration-of-common-pain-medications.pdf
Methadone 30 -60 1 -2 4 -6 Full analgesic effects, are not attained until 3 to 5 days after initiation of dosing. Drug is known to eliminate slowly causing high risk of overdose Oral Sedation, nausea/vomiting, constipation, respiratory depression, delirium, pruritis, life-Threatening QT Prolongation, monitor patients closely for respiratory
[PDF File] Opioid Equianalgesic Table - University of Toronto
http://5y1.org/file/22228/opioid-equianalgesic-table-university-of-toronto.pdf
Step 1: Calculate current total daily usage of opioids. Morphine 30 mg /dose x 6 doses/day = 180mg/day. Step 2: Calculate the equipotent dose (consult conversion table). 30 mg morphine po = 1.5 mg hydromorphone IV 180 mg morphine po = x hydromorphone IV. x = 1.5 x 180 ÷ 30 x = 9 mg Therefore, 180mg morphine po/day = 9mg hydromorphone …
[PDF File] Opioid Conversion Tables - ASHP
http://5y1.org/file/22228/opioid-conversion-tables-ashp.pdf
Opioid Conversion Tables. Ernest Dole, Pharm.D., BCPS, PhC, FASHP Clinical Pharmacist, University of New Mexico Hospitals Chronic Pain Consultation & Treatment Center. Table 1: Pharmacokinetic Data for Oral Opioids. Starting Dose.
[PDF File] Title: SBAR: Situation- IV Methadone - Trinity Health
http://5y1.org/file/22228/title-sbar-situation-iv-methadone-trinity-health.pdf
rgical pain compared to currently available formulary alterna. ives. Background:Methadone is a synthetic, potent, mu-opioid receptor agonist. It predominantly a. ts on the central nervous system (CNS) and other organs composed of smooth muscle. Data also suggests this drug acts as a N-methyl-D-aspartate (NMDA) rec.
[PDF File] Opioid Oral Morphine Milligram Equivalent (MME) Conversion …
http://5y1.org/file/22228/opioid-oral-morphine-milligram-equivalent-mme-conversion.pdf
decision-making warrants caution. This is particularly true with regard to methadone (see viii below). ii. National Center for Injury Prevention and Control. CDC compilation of benzodiazepines, muscle relaxants, stimulants, zolpidem, and opioid analgesics with oral morphine milligram equivalent conversion factors, 2017version. Atlanta, GA: Centers
[PDF File] Methadone Dose Conversion Guidelines - Compassion and …
http://5y1.org/file/22228/methadone-dose-conversion-guidelines-compassion-and.pdf
er dayStep 2. Convert to methadone.For a dosage of 800 mg per day, the conversion ratio of morphine to methadone is 15:1 (see “Conversion table from morphi. morphi. e = 53 mg methadone per dayStep 3. Reduce the dosage b. cause of incomplete cross-tolerance.Reduce the equianalgesic dose by 1/2 when switching opioids b.
[PDF File] Opioid dose conversion guide - Brighton and Sussex …
http://5y1.org/file/22228/opioid-dose-conversion-guide-brighton-and-sussex.pdf
opioid conversion. 14.1 FINAL. Opioid dose conversion guide. Adapted from BNF 2020 The conversations are approximations and need to be adjusted to the individual patient. Oral morphine. Subcutaneous morphine. Oral oxycodone. Subcutaneous oxycodone/diamorphine*. Subcutaneous alfentanil.
[PDF File] Inpatient Management of Opioid Use Disorder: Methadone
http://5y1.org/file/22228/inpatient-management-of-opioid-use-disorder-methadone.pdf
2.Discuss options with patient and obtain patient preference for methadone vs. buprenorphine (see Appendix B – Non-pregnancy Decision Guide; Pregnancy Only: See Appendix C – Pregnancy Only Decision Guide). ... dosing intervals and IV vs PO bioavailability with pharmacy prior to use. For questions or concerns, please consider …
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