Midazolam versus diazepam
[DOC File]SMALL ANIMAL ANESTHESIA GUIDE - VASG
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Although pharmacokinetic studies would suggest that midazolam would seem preferable to diazepam, in one randomized study comparing sedation for cardioversion with either diazepam or midazolam efficacy of sedation and amnesia were the same but normalization of mental test score was much quicker with the use of diazepam.
Midazolam versus diazepam as premedication for upper gastrointe…
In 1997, Chamberlain et al. conducted the randomized comparative study on intramuscular midazolam versus intravenous diazepam in 24 patients of which 22 patients had good effective control of seizures and concluded that intramuscular midazolam has good rapid absorption rate and more rapid cessation of seizures.
[DOC File]Practice Guidelines for Sedation and Analgesia by Non ...
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The administration of buccal midazolam and rectal diazepam should be given in accordance with this document. 2. BACKGROUND. 2.1 Midazolam is a short acting benzodiazepine. Pharmacokinetic data following administration of buccal midazolam in adults shows good bioavailability and maximum peak plasma concentration within 30 minutes. It comes in a ...
[DOC File]Rescue treatment of prolonged and serial convulsive ...
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Midazolam (only) General Description. Benzodiazepine (as is diazepam) Unlike diazepam, midazolam is quickly and predictably absorbed when given by the IM route. Of little use as a sole agent due to minimal sedation in normal healthy adult patients. Generally combined with an opioid or ketamine. Patient selection. Recommended use
Safe Sedation in Modern Cardiological Practice
Drug Onset Half-Life Duration Diazepam (Valium) 2 – 5 min 21 – 37 H 15 – 60 min Midazolam (Versed) 1.5 – 5 min 2 – 5 H Usual: 20 – 30 min. 2 – 6 H Flumazenil (Romazicon) 1 – 2 min 41 – 79 min titrate BENZODIAZEPINES - DIFFERENCES. Midazolam Water-soluble; selective metabolism to INACTIVE metabolite (1-hydroxymidazolam)
Sussex Partnership NHS Foundation Trust
Diazepam is a longer acting benzodiazepine compared to midazolam. Diazepam undergoes extensive hepatic metabolism. Two major metabolites of diazepam, demethyldiazepam and oxazepam both have pharmacologic activity and contribute to diazepam's long duration of action. In the geriatric patient, the half-life may be up to 96 hours.
[DOC File]RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES …
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Midazolam versus diazepam for combined esophogastroduodenoscopy and colonoscopy. Digestive Diseases & Sciences 34:1265-1271, 1989 Buck ML, Blumer JL: Phenothiazine-associated apnea in two siblings.
[DOCX File]Moderate Sedation Bibliography
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Buccal or intranasal midazolam is as effective and safe as rectal diazepam in the treatment of prolonged or serial convulsive seizures and is a preferable alternative to rectal diazepam in a community setting 3, 4, 5. 1. Prescription of rectal diazepam or buccal midazolam for the treatment of prolonged or serial / cluster seizures in the community:
[DOC File]CONSCIOUS SEDATION
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Mechanism of action of benzodiazepines Diazepam metabolism. Differences between midazolam & diazepam. Metabolism of midazolam vs diazepam Formulation and pharmacology of midazolam Structure of midazolam Flumazenil Alpha-2 agonists in anaesthesia Neuromuscular Blocking Drugs What is muscle relaxation and how can it be achieved.
[DOC File]Basic Pharmacology - Angelfire
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Ginsberg GG, Lewis JH, Gallagher JE, Fleischer DE, Al-Kawas FH, Nguyen CC, Mundt DJ, Benjamin SB: Diazepam versus midazolam for colonoscopy: a prospective evaluation of predicted versus actual dosing requirements. Gastrointest Endosc 1992; 38:651-6
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