Mineralocorticoid antagonist
[DOCX File]hfcollaboratory.com
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In one study, ABT occurred in approximately 30% of dogs (32% in CHF and 30% not in CHF) despite ACEI administration. This phenomenon is the reason spironolactone, a mineralocorticoid receptor antagonist (MRA), is recommended to augment the traditional triple-therapy approach to CHF management in dogs.
[DOCX File]Attachment 1. Product Information for Eplerenone
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Spironolactone MR antagonist trt Mineralocorticoid Excess hyperkalemia, hyperchloremia reduce Na ion channels and Na/K ATPase Mifepristone GC receptor antagonist Cushings disease Both Aldosterone and Cortisol bind MR with equal affinity thus regulated by GR expression (all nucleated cells) versus MR expression (kidney, ...
[DOC File]Aldosterone Antagonists (Eplerenone, Spironolactone) in …
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Eplerenone is a relatively selective mineralocorticoid receptor antagonist with weak binding to androgen, glucocorticoid and progesterone receptors. Eplerenone prevents the binding of aldosterone, a key hormone in the renin-angiotensin-aldosterone-system (RAAS), which is involved in the regulation of blood pressure and the pathophysiology of ...
[DOC File]Glucocorticoids - University of Kentucky
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Mineralocorticoid Receptor Antagonist at goal dose О yes О no. If Mineralocorticoid Receptor Antagonist not at goal dose, this is due to (select all that apply): О Hyperkalemia. О Renal Dysfunction. О Hypotension. О Bradycardia. О Other Side Effect or Intolerance.
[DOCX File]Illinois State Veterinary Medical Association - The …
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cortisol (11(-hydroxylase) Fludrocortisone Mineralocorticoid deficiency HTN, hypokalemia 10X affinity for MR than GR Spironolactone MR antagonist Mineralocorticoid excess Hyperkalemia, hyperchloremia High doses inhibit AR Calcium homeostasis Calcitriol 1,25-(OH)2-vit.D Vit.D-dependent rickets. Renal osteodystrophy. Psoriasis, leukemia
List of Aldosterone receptor antagonists
Nov 14, 2010 · A mineralocorticoid receptor antagonist should also be used with caution in patients with a higher baseline potassium (e.g., > 4.2mEq/L), elevated serum creatinine (e.g., > 1.6 mg/dl), or receiving ACEIs7, angiotensin II receptor antagonists, or other medications that may increase the risk for hyperkalemia (e.g., cyclosporine, tacrolimus ...
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